PinSnps

 Human Protein Networks and SNPs

           Exploring the impact of SNPs on Protein Domains and Complexes








About

PinSnps is an interactive tool for the analysis of common variants, disease-related SNPs, Post-Translational Modifications (PTMs) and related functional sites mapped onto human protein interaction networks.

Based on these curated data pre-mapped onto protein sequences and, where available, structures, one can query the server following four different query scenarios:

1) single protein based search and information retrieval;

2) list of interacting proteins search and information retrieval;

3) search mutation data by dbSNP id;

4) search mutation data from Cosmic and by tissue type.



1) Single Protein

? Please enter one UniProt accession identifier to query for the protein's structure information.

Space and return characters are removed automatically.

Example: P01116




2) Protein Network

? Please enter at least one UniProt accession identifier (up to 10) to query protein interaction and structure information.

Please separate UniProt ACs by using commas. Space and return characters are removed automatically.

Example: P01116,P15056




3) dbSNP Entry

? Please enter at least one dbSNP ID rs# (up to 10) to query for the proteins that contain the corresponding SNPs.

Please separate the IDs by using commas. Space and return characters are removed automatically.

Example: 146221509,376122558




4) COSMIC Entry

? Select one type of cancer by primary site in order to list all proteins with known COSMIC SNPs.
  • Large Intestine
  • Testis
  • Gastrointestinal Tract
  • Liver
  • Lung
  • Salivary Gland
  • Kidney
  • Thymus
  • Eye
  • Ovary
  • Meninges
  • Pancreas
  • Parathyroid
  • Endometrium
  • Pleura
  • Haematopoietic and Lymphoid Tissue
  • Thyroid
  • Stomach
  • Oesophagus
  • Vulva
  • Cervix
  • Genital Tract
  • Biliary Tract
  • Upper Aerodigestive Tract
  • Central Nervous System
  • Urinary Tract
  • Pituitary
  • Autonomic Ganglia
  • Breast
  • Skin
  • Bone
  • Prostate
  • Soft Tissue
  • Adrenal Gland
  • Peritoneum
  • Small Intestine