TITINdb

Map SAVs to Structure

Position	Domain position	SAV	Structural Position	RS	Q(SASA)	Disease	Source	MAF
18166	1	L/F	1	rs878953621	0.6041	None	gnomAD-4.0.0	6.84993E-07
18168	3	G/R	3	rs2054202979	0.2313	None	gnomAD-3.1.2	6.58E-06
18168	3	G/R	3	rs2054202979	0.2313	None	gnomAD-4.0.0	6.58207E-06
18169	4	P/H	4	rs2054202479	0.4462	None	gnomAD-3.1.2	6.58E-06
18169	4	P/H	4	rs2054202479	0.4462	None	gnomAD-4.0.0	6.58094E-06
18169	4	P/L	4	None	0.4462	None	gnomAD-4.0.0	2.05477E-06
18169	4	P/R	4	None	0.4462	None	gnomAD-4.0.0	6.84925E-07
18171	6	G/R	6	rs751216891	0.2619	None	gnomAD-2.1.1	4.04E-06
18171	6	G/R	6	rs751216891	0.2619	None	gnomAD-4.0.0	3.42444E-06
18172	7	K/T	7	rs1236991246	0.3447	None	gnomAD-2.1.1	4.04E-06
18172	7	K/T	7	rs1236991246	0.3447	None	gnomAD-3.1.2	6.58E-06
18172	7	K/T	7	rs1236991246	0.3447	None	gnomAD-4.0.0	3.85074E-06
18173	8	P/Q	9	rs794729458	0.1340	None	gnomAD-2.1.1	4.04E-06
18173	8	P/Q	9	rs794729458	0.1340	None	gnomAD-3.1.2	5.27E-05
18173	8	P/Q	9	rs794729458	0.1340	None	gnomAD-4.0.0	1.1167E-05
18173	8	P/S	9	rs766074604	0.1340	None	gnomAD-2.1.1	2.36557E-04
18173	8	P/S	9	rs766074604	0.1340	None	gnomAD-3.1.2	5.27E-05
18173	8	P/S	9	rs766074604	0.1340	None	gnomAD-4.0.0	9.62894E-05
18174	9	K/N	11	None	0.7828	None	gnomAD-3.1.2	6.58E-06
18174	9	K/N	11	None	0.7828	None	gnomAD-4.0.0	1.24062E-06
18175	10	V/I	12	rs776320086	0.2958	None	gnomAD-2.1.1	8.07E-06
18175	10	V/I	12	rs776320086	0.2958	None	gnomAD-4.0.0	5.4788E-06
18175	10	V/L	12	None	0.2958	None	gnomAD-4.0.0	1.3697E-06
18176	11	L/F	13	rs553262724	0.5981	None	gnomAD-2.1.1	3.19E-05
18176	11	L/F	13	rs553262724	0.5981	None	gnomAD-3.1.2	6.58E-06
18176	11	L/F	13	rs553262724	0.5981	None	gnomAD-4.0.0	4.34202E-06
18176	11	L/M	13	rs1211482141	0.5981	None	gnomAD-2.1.1	4.04E-06
18176	11	L/M	13	rs1211482141	0.5981	None	gnomAD-3.1.2	6.58E-06
18176	11	L/M	13	rs1211482141	0.5981	None	gnomAD-4.0.0	2.48116E-06
18176	11	L/S	13	None	0.5981	None	gnomAD-4.0.0	1.3697E-06
18177	12	A/P	14	rs373546809	0.4266	None	gnomAD-2.1.1	4.04E-06
18177	12	A/P	14	rs373546809	0.4266	None	gnomAD-3.1.2	6.58E-06
18177	12	A/P	14	rs373546809	0.4266	None	gnomAD-4.0.0	6.58233E-06
18177	12	A/T	14	None	0.4266	None	gnomAD-4.0.0	1.59486E-06
18177	12	A/V	14	None	0.4266	None	gnomAD-4.0.0	1.59478E-06
18178	13	R/C	15	rs554701601	0.5437	None	gnomAD-2.1.1	2.51E-05
18178	13	R/C	15	rs554701601	0.5437	None	gnomAD-3.1.2	2.63E-05
18178	13	R/C	15	rs554701601	0.5437	None	1000 genomes	3.99361E-04
18178	13	R/C	15	rs554701601	0.5437	None	gnomAD-4.0.0	2.48118E-05
18178	13	R/G	15	None	0.5437	None	gnomAD-4.0.0	6.84881E-07
18178	13	R/H	15	rs879023208	0.5437	None	gnomAD-2.1.1	4.04E-06
18178	13	R/H	15	rs879023208	0.5437	None	gnomAD-3.1.2	6.58E-06
18178	13	R/H	15	rs879023208	0.5437	None	gnomAD-4.0.0	6.82426E-06
18179	14	T/A	16	None	0.3434	None	gnomAD-4.0.0	2.05441E-06
18179	14	T/I	16	rs765149899	0.3434	None	gnomAD-2.1.1	4.04E-06
18179	14	T/I	16	rs765149899	0.3434	None	gnomAD-4.0.0	1.59458E-06
18180	15	K/E	17	None	0.4615	None	gnomAD-4.0.0	1.59444E-06
18180	15	K/R	17	rs1283224972	0.4615	None	gnomAD-2.1.1	4.04E-06
18180	15	K/R	17	rs1283224972	0.4615	None	gnomAD-4.0.0	3.18897E-06
18181	16	G/E	18	rs776456385	0.2287	None	gnomAD-4.0.0	6.84793E-07
18181	16	G/R	18	rs761810379	0.2287	None	gnomAD-2.1.1	8.07E-06
18181	16	G/R	18	rs761810379	0.2287	None	gnomAD-3.1.2	6.58E-06
18181	16	G/R	18	rs761810379	0.2287	None	gnomAD-4.0.0	1.24051E-06
18181	16	G/V	18	rs776456385	0.2287	None	gnomAD-2.1.1	8.07E-06
18181	16	G/V	18	rs776456385	0.2287	None	gnomAD-4.0.0	1.36959E-06
18182	17	S/L	19	rs1470054004	0.2188	None	gnomAD-3.1.2	6.58E-06
18182	17	S/L	19	rs1470054004	0.2188	None	gnomAD-4.0.0	2.56678E-06
18183	18	M/I	20	rs1217449889	0.0947	None	gnomAD-2.1.1	3.19E-05
18183	18	M/I	20	rs1217449889	0.0947	None	gnomAD-3.1.2	6.58E-06
18183	18	M/I	20	rs1217449889	0.0947	None	gnomAD-4.0.0	6.58085E-06
18183	18	M/V	20	rs1214008596	0.0947	None	gnomAD-3.1.2	6.58E-06
18183	18	M/V	20	rs1214008596	0.0947	None	gnomAD-4.0.0	6.57929E-06
18187	22	W/C	24	rs2054184713	0.1264	None	gnomAD-3.1.2	6.58E-06
18187	22	W/C	24	rs2054184713	0.1264	None	gnomAD-4.0.0	6.58042E-06
18187	22	W/G	24	rs796392077	0.1264	None	gnomAD-2.1.1	3.19E-05
18187	22	W/G	24	rs796392077	0.1264	None	gnomAD-3.1.2	1.32E-05
18187	22	W/G	24	rs796392077	0.1264	None	gnomAD-4.0.0	3.04529E-06
18188	23	T/I	25	None	0.5605	None	gnomAD-4.0.0	1.59411E-06
18188	23	T/N	25	None	0.5605	None	gnomAD-4.0.0	1.59411E-06
18188	23	T/S	25	None	0.5605	None	gnomAD-4.0.0	1.59411E-06
18189	24	P/T	26	rs2054184050	0.4581	None	gnomAD-3.1.2	6.58E-06
18189	24	P/T	26	rs2054184050	0.4581	None	gnomAD-4.0.0	2.03023E-06
18193	28	N/S	30	rs777505893	0.4162	None	gnomAD-2.1.1	4.03E-05
18193	28	N/S	30	rs777505893	0.4162	None	gnomAD-3.1.2	1.97E-05
18193	28	N/S	30	rs777505893	0.4162	None	gnomAD-4.0.0	4.89916E-05
18194	29	G/D	31	rs201802447	0.3657	None	gnomAD-2.1.1	7.16E-05
18194	29	G/D	31	rs201802447	0.3657	None	gnomAD-3.1.2	5.26E-05
18194	29	G/D	31	rs201802447	0.3657	None	gnomAD-4.0.0	7.31786E-05
18194	29	G/S	31	None	0.3657	None	gnomAD-4.0.0	1.20032E-06
18195	30	G/S	32	rs2054179912	0.6759	None	gnomAD-4.0.0	3.18767E-06
18196	31	S/P	33	None	0.2441	None	gnomAD-4.0.0	1.59371E-06
18197	32	P/A	34	rs1475050139	0.7200	None	gnomAD-3.1.2	6.58E-06
18197	32	P/A	34	rs1475050139	0.7200	None	gnomAD-4.0.0	6.58189E-06
18197	32	P/S	34	rs1475050139	0.7200	None	gnomAD-4.0.0	1.59361E-06
18198	33	I/T	35	rs745885044	0.2323	None	gnomAD-2.1.1	4.03E-06
18198	33	I/T	35	rs745885044	0.2323	None	gnomAD-4.0.0	1.59357E-06
18198	33	I/V	35	None	0.2323	None	gnomAD-4.0.0	2.73854E-06
18200	35	G/D	37	None	0.1136	None	gnomAD-4.0.0	1.59345E-06
18201	36	Y/H	38	rs779191742	0.1494	None	gnomAD-2.1.1	8.06E-06
18201	36	Y/H	38	rs779191742	0.1494	None	gnomAD-4.0.0	4.77992E-06
18202	37	W/C	39	rs1476258275	0.1935	None	gnomAD-2.1.1	4.03E-06
18202	37	W/C	39	rs1476258275	0.1935	None	gnomAD-4.0.0	1.59335E-06
18202	37	W/R	39	None	0.1935	None	gnomAD-4.0.0	1.20032E-06
18203	38	L/P	40	rs771560830	0.0938	None	gnomAD-2.1.1	4.03E-06
18203	38	L/P	40	rs771560830	0.0938	None	gnomAD-4.0.0	4.78005E-06
18203	38	L/V	40	None	0.0938	None	gnomAD-4.0.0	1.20032E-06
18204	39	E/G	41	rs778173480	0.1341	None	gnomAD-4.0.0	1.5949E-05
18204	39	E/Q	41	rs749849370	0.1341	None	gnomAD-2.1.1	1.21E-05
18204	39	E/Q	41	rs749849370	0.1341	None	gnomAD-3.1.2	6.58E-06
18204	39	E/Q	41	rs749849370	0.1341	None	gnomAD-4.0.0	6.82064E-06
18204	39	E/V	41	rs778173480	0.1341	None	gnomAD-2.1.1	4.04E-06
18204	39	E/V	41	rs778173480	0.1341	None	gnomAD-4.0.0	1.59476E-06
18206	41	R/T	43	None	0.2081	None	gnomAD-4.0.0	1.59315E-06
18207	42	E/K	44	None	0.3947	None	gnomAD-4.0.0	1.59316E-06
18208	43	E/K	50	rs575533984	0.4503	None	gnomAD-2.1.1	1.61E-05
18208	43	E/K	50	rs575533984	0.4503	None	gnomAD-3.1.2	6.58E-06
18208	43	E/K	50	rs575533984	0.4503	None	1000 genomes	1.99681E-04
18208	43	E/K	50	rs575533984	0.4503	None	gnomAD-4.0.0	6.20001E-06
18210	45	S/I	60	None	0.2420	None	gnomAD-4.0.0	6.84561E-07
18210	45	S/T	60	None	0.2420	None	gnomAD-4.0.0	6.84561E-07
18211	46	P/L	63	rs764772164	0.6774	None	gnomAD-3.1.2	6.58E-06
18211	46	P/L	63	rs764772164	0.6774	None	gnomAD-4.0.0	1.86004E-06
18211	46	P/R	63	rs764772164	0.6774	None	gnomAD-3.1.2	1.32E-05
18211	46	P/R	63	rs764772164	0.6774	None	gnomAD-4.0.0	1.67415E-05
18211	46	P/S	63	rs727504192	0.6774	None	gnomAD-3.1.2	6.58E-06
18211	46	P/S	63	rs727504192	0.6774	None	gnomAD-4.0.0	6.58085E-06
18211	46	P/T	63	rs727504192	0.6774	None	gnomAD-2.1.1	7.86E-05
18211	46	P/T	63	rs727504192	0.6774	None	gnomAD-3.1.2	8.56E-05
18211	46	P/T	63	rs727504192	0.6774	None	gnomAD-4.0.0	2.03997E-04
18212	47	Y/F	64	rs772610346	0.9767	None	gnomAD-4.0.0	2.40064E-06
18213	48	W/S	65	None	0.2381	None	gnomAD-4.0.0	1.59315E-06
18215	50	R/C	67	rs187167219	0.3145	None	gnomAD-2.1.1	6.44E-05
18215	50	R/C	67	rs187167219	0.3145	None	gnomAD-3.1.2	1.32E-05
18215	50	R/C	67	rs187167219	0.3145	None	1000 genomes	1.99681E-04
18215	50	R/C	67	rs187167219	0.3145	None	gnomAD-4.0.0	2.04608E-05
18215	50	R/H	67	rs183010574	0.3145	None	gnomAD-2.1.1	1.21E-05
18215	50	R/H	67	rs183010574	0.3145	None	gnomAD-3.1.2	6.58E-06
18215	50	R/H	67	rs183010574	0.3145	None	gnomAD-4.0.0	1.24007E-05
18215	50	R/P	67	rs183010574	0.3145	None	gnomAD-2.1.1	2.86E-05
18215	50	R/P	67	rs183010574	0.3145	None	gnomAD-3.1.2	1.32E-05
18215	50	R/P	67	rs183010574	0.3145	None	1000 genomes	1.99681E-04
18215	50	R/P	67	rs183010574	0.3145	None	gnomAD-4.0.0	8.67985E-06
18216	51	V/I	68	rs2054164910	0.2063	None	gnomAD-3.1.2	1.32E-05
18216	51	V/I	68	rs2054164910	0.2063	None	gnomAD-4.0.0	5.13006E-06
18217	52	S/G	69	rs201001270	0.2071	None	gnomAD-2.1.1	2.86E-05
18217	52	S/G	69	rs201001270	0.2071	None	gnomAD-3.1.2	3.95E-05
18217	52	S/G	69	rs201001270	0.2071	None	gnomAD-4.0.0	6.51028E-05
18218	53	R/Q	70	rs143643360	1.0205	None	gnomAD-2.1.1	1.79E-05
18218	53	R/Q	70	rs143643360	1.0205	None	gnomAD-3.1.2	1.32E-05
18218	53	R/Q	70	rs143643360	1.0205	None	1000 genomes	1.99681E-04
18218	53	R/Q	70	rs143643360	1.0205	None	gnomAD-4.0.0	2.728E-05
18219	54	A/V	72	rs546735795	0.3959	None	gnomAD-2.1.1	4.02E-06
18219	54	A/V	72	rs546735795	0.3959	None	gnomAD-3.1.2	6.58E-06
18219	54	A/V	72	rs546735795	0.3959	None	1000 genomes	1.99681E-04
18219	54	A/V	72	rs546735795	0.3959	None	gnomAD-4.0.0	6.57825E-06
18221	56	I/L	77	rs375091820	0.1216	None	gnomAD-2.1.1	4.02E-06
18221	56	I/L	77	rs375091820	0.1216	None	gnomAD-4.0.0	6.8451E-07
18221	56	I/T	77	rs1418665991	0.1216	None	gnomAD-2.1.1	4.02E-06
18221	56	I/T	77	rs1418665991	0.1216	None	gnomAD-4.0.0	1.59294E-06
18221	56	I/V	77	rs375091820	0.1216	None	gnomAD-2.1.1	2.14E-05
18221	56	I/V	77	rs375091820	0.1216	None	gnomAD-4.0.0	1.57437E-05
18223	58	K/T	79	rs771180692	0.9802	None	gnomAD-2.1.1	3.93E-05
18223	58	K/T	79	rs771180692	0.9802	None	gnomAD-3.1.2	1.97E-05
18223	58	K/T	79	rs771180692	0.9802	None	gnomAD-4.0.0	1.11609E-05
18224	59	V/A	80	rs749405835	0.5990	None	gnomAD-2.1.1	4.02E-06
18224	59	V/A	80	rs749405835	0.5990	None	gnomAD-4.0.0	9.55782E-06
18225	60	G/V	81	rs886038866	0.3035	None	gnomAD-4.0.0	9.55773E-06
18227	62	K/N	83	rs371332455	1.0756	None	gnomAD-2.1.1	8.04E-06
18227	62	K/N	83	rs371332455	1.0756	None	gnomAD-4.0.0	1.59306E-06
18228	63	G/D	88	rs2154194670	0.2496	None	gnomAD-3.1.2	6.58E-06
18228	63	G/D	88	rs2154194670	0.2496	None	gnomAD-4.0.0	6.57592E-06
18229	64	V/L	89	rs116142642	0.0843	None	gnomAD-2.1.1	2.01E-05
18229	64	V/L	89	rs116142642	0.0843	None	gnomAD-4.0.0	3.4227E-06
18229	64	V/M	89	rs116142642	0.0843	None	gnomAD-2.1.1	1.39335E-04
18229	64	V/M	89	rs116142642	0.0843	None	gnomAD-3.1.2	1.11891E-04
18229	64	V/M	89	rs116142642	0.0843	None	1000 genomes	5.99042E-04
18229	64	V/M	89	rs116142642	0.0843	None	gnomAD-4.0.0	6.94407E-05
18230	65	E/V	90	None	0.4591	None	gnomAD-4.0.0	3.60097E-06
18231	66	F/L	91	None	0.2282	None	gnomAD-4.0.0	1.20032E-06
18233	68	V/A	93	None	0.1066	None	gnomAD-4.0.0	1.5933E-06
18233	68	V/D	93	rs1060500469	0.1066	None	gnomAD-3.1.2	6.58E-06
18233	68	V/D	93	rs1060500469	0.1066	None	gnomAD-4.0.0	6.5825E-06
18233	68	V/I	93	rs374996996	0.1066	None	gnomAD-2.1.1	8.05E-06
18234	69	P/T	94	rs1060500416	0.4062	None	gnomAD-3.1.2	6.58E-06
18234	69	P/T	94	rs1060500416	0.4062	None	gnomAD-4.0.0	6.58371E-06
18235	70	R/C	96	rs758019427	0.7782	None	gnomAD-2.1.1	1.21E-05
18235	70	R/C	96	rs758019427	0.7782	None	gnomAD-4.0.0	2.73845E-06
18235	70	R/G	96	rs758019427	0.7782	None	gnomAD-2.1.1	8.05E-06
18235	70	R/G	96	rs758019427	0.7782	None	gnomAD-3.1.2	6.59E-06
18235	70	R/G	96	rs758019427	0.7782	None	gnomAD-4.0.0	3.10069E-06
18235	70	R/H	96	rs750125113	0.7782	None	gnomAD-2.1.1	8.05E-06
18235	70	R/H	96	rs750125113	0.7782	None	gnomAD-4.0.0	8.89995E-06
18236	71	L/F	97	rs1273412223	0.1348	None	gnomAD-2.1.1	4.02E-06
18236	71	L/F	97	rs1273412223	0.1348	None	gnomAD-4.0.0	1.59341E-06
18236	71	L/S	97	None	0.1348	None	gnomAD-4.0.0	2.05377E-06
18236	71	L/W	97	None	0.1348	None	gnomAD-4.0.0	6.84589E-07
18237	72	L/P	98	rs201412693	0.6850	None	gnomAD-2.1.1	6.42972E-04
18237	72	L/P	98	rs201412693	0.6850	None	gnomAD-3.1.2	6.12076E-04
18237	72	L/P	98	rs201412693	0.6850	None	1000 genomes	7.98722E-04
18237	72	L/P	98	rs201412693	0.6850	CNM	Literature	None
18237	72	L/P	98	rs201412693	0.6850	None	gnomAD-4.0.0	9.12083E-04
18237	72	L/R	98	rs201412693	0.6850	None	gnomAD-2.1.1	4.02E-06
18237	72	L/R	98	rs201412693	0.6850	None	gnomAD-4.0.0	1.1638E-05
18238	73	E/Q	99	None	0.5409	None	gnomAD-4.0.0	1.59345E-06
18240	75	V/I	102	rs375141729	0.1974	None	gnomAD-2.1.1	4.64E-05
18240	75	V/I	102	rs375141729	0.1974	None	gnomAD-3.1.2	1.84327E-04
18240	75	V/I	102	rs375141729	0.1974	None	gnomAD-4.0.0	5.20872E-05
18243	78	Q/E	105	rs372447571	0.1571	None	gnomAD-2.1.1	4.02E-06
18243	78	Q/E	105	rs372447571	0.1571	None	gnomAD-4.0.0	2.05395E-06
18243	78	Q/H	105	rs548723690	0.1571	None	gnomAD-2.1.1	8.05E-06
18243	78	Q/H	105	rs548723690	0.1571	None	gnomAD-3.1.2	1.32E-05
18243	78	Q/H	105	rs548723690	0.1571	None	1000 genomes	1.99681E-04
18243	78	Q/H	105	rs548723690	0.1571	None	gnomAD-4.0.0	2.4804E-06
18244	79	F/L	106	rs1301615048	0.1230	None	gnomAD-2.1.1	1.07E-05
18244	79	F/L	106	rs1301615048	0.1230	None	gnomAD-3.1.2	1.97E-05
18244	79	F/L	106	rs1301615048	0.1230	None	gnomAD-4.0.0	6.41513E-06
18245	80	R/G	107	rs2054149835	0.1739	None	gnomAD-3.1.2	6.58E-06
18245	80	R/G	107	rs2054149835	0.1739	None	gnomAD-4.0.0	6.58085E-06
18245	80	R/K	107	None	0.1739	None	gnomAD-4.0.0	2.05397E-06
18245	80	R/T	107	None	0.1739	None	gnomAD-4.0.0	1.36931E-06
18247	82	M/I	109	rs368858337	0.1454	None	gnomAD-2.1.1	1.21E-05
18247	82	M/I	109	rs368858337	0.1454	None	gnomAD-3.1.2	6.58E-06
18247	82	M/I	109	rs368858337	0.1454	None	gnomAD-4.0.0	1.61261E-05
18247	82	M/T	109	rs200585270	0.1454	None	gnomAD-2.1.1	2.93098E-04
18247	82	M/T	109	rs200585270	0.1454	None	gnomAD-3.1.2	1.51348E-04
18247	82	M/T	109	rs200585270	0.1454	None	gnomAD-4.0.0	1.27761E-04
18251	86	A/T	113	None	0.6502	None	gnomAD-4.0.0	1.20032E-06
18252	87	A/V	114	rs551602191	0.4694	None	gnomAD-2.1.1	4.03E-06
18252	87	A/V	114	rs551602191	0.4694	None	gnomAD-3.1.2	6.58E-06
18252	87	A/V	114	rs551602191	0.4694	None	gnomAD-4.0.0	1.2837E-05
18253	88	G/A	115	None	0.2010	None	gnomAD-4.0.0	1.59524E-06
18253	88	G/R	115	None	0.2010	None	gnomAD-4.0.0	1.5949E-06
18254	89	I/F	117	rs766737617	0.4497	None	gnomAD-2.1.1	1.21E-05
18254	89	I/F	117	rs766737617	0.4497	None	gnomAD-3.1.2	6.58E-06
18254	89	I/F	117	rs766737617	0.4497	None	gnomAD-4.0.0	1.36479E-05
18254	89	I/T	117	rs1356331923	0.4497	None	gnomAD-2.1.1	4.03E-06
18254	89	I/T	117	rs1356331923	0.4497	None	gnomAD-4.0.0	3.42479E-06
18255	90	G/A	118	None	0.2115	None	gnomAD-4.0.0	6.85044E-07
18255	90	G/S	118	rs762872466	0.2115	None	gnomAD-2.1.1	4.03E-06
18255	90	G/S	118	rs762872466	0.2115	None	gnomAD-4.0.0	1.59559E-06
18257	92	P/L	120	rs1429008245	0.4096	None	gnomAD-4.0.0	1.59652E-06
18258	93	S/N	121	None	0.1268	None	gnomAD-4.0.0	6.85289E-07
18258	93	S/T	121	rs770198717	0.1268	None	gnomAD-2.1.1	4.03E-06
18259	94	E/K	122	None	0.5904	None	gnomAD-4.0.0	1.20032E-06
18260	95	P/T	123	None	0.3330	None	gnomAD-4.0.0	1.59858E-06
18261	96	S/P	124	None	0.1119	None	gnomAD-4.0.0	1.20032E-06
18262	97	D/G	125	None	0.6956	None	gnomAD-4.0.0	1.6019E-06
18263	98	P/A	126	None	0.3548	None	gnomAD-4.0.0	1.60278E-06
18263	98	P/L	126	None	0.3548	None	gnomAD-4.0.0	6.86437E-07
18264	99	E/A	127	None	0.3414	None	gnomAD-4.0.0	1.60669E-06
18264	99	E/K	127	rs1253287416	0.3414	None	gnomAD-2.1.1	4.04E-06
18264	99	E/K	127	rs1253287416	0.3414	None	gnomAD-4.0.0	4.12128E-06
18264	99	E/Q	127	rs1253287416	0.3414	None	gnomAD-4.0.0	2.74752E-06
18265	100	V/A	129	rs2054138018	0.3837	None	gnomAD-3.1.2	6.58E-06
18265	100	V/A	129	rs2054138018	0.3837	None	gnomAD-4.0.0	3.91767E-06
18265	100	V/I	129	rs397517621	0.3837	None	gnomAD-4.0.0	1.61921E-06
18266	101	A/S	130	rs199837769	0.1117	None	gnomAD-2.1.1	1.15539E-04
18266	101	A/S	130	rs199837769	0.1117	None	gnomAD-3.1.2	1.1844E-04
18266	101	A/S	130	rs199837769	0.1117	None	gnomAD-4.0.0	1.40839E-04
18266	101	A/T	130	None	0.1117	None	gnomAD-4.0.0	1.38351E-06
18267	102	G/E	131	rs878876923	0.2180	None	gnomAD-3.1.2	6.58E-06
18267	102	G/E	131	rs878876923	0.2180	None	gnomAD-4.0.0	2.61866E-06
18268	103	D/H	132	rs776957882	0.6505	None	gnomAD-2.1.1	4.11E-06
18268	103	D/H	132	rs776957882	0.6505	None	gnomAD-4.0.0	1.67442E-06
18268	103	D/N	132	None	0.6505	None	gnomAD-3.1.2	6.58E-06
18268	103	D/N	132	None	0.6505	None	gnomAD-4.0.0	2.66966E-06
18268	103	D/Y	132	rs776957882	0.6505	None	gnomAD-4.0.0	1.67442E-06

Position	Domain position	SAV	RS	Q(SASA)	Source	Structural Position	Disease	AlphaMissense (IC)	AlphaMissense (N2AB)	CADD	Condel	DUET	FATHMM	M-CAP	mCSM	MetaLR	MetaSVM	MPC	MutationAssessor	MutationTaster	MutPred	MVP	PolyPhen-2	PrimateAI	PROVEAN	REVEL	Rhapsody	SIFT	Zygosity	Comments	MAF	AFR	AMR	AMS	ASJ	EAS	EUR	FIN	MDE	NFE	SAS	OTH	Site Annotation	Predicted PPI	mCSM-PPI
18166	1	L/F	rs878953621	0.6041	gnomAD-4.0.0	1	None	0.2735	0.2688	27.1	N	None	0.57	0.048413	-0.708	0.2138	-0.5804	0.17616981747	2.5	0.998858	0.256	0.402043589563	0.623	0.439826667309	-3.05	0.167	0.51	0.029	None	None	6.84993E-07	2.99563E-05	0	0	0	None	0	0	6.84993E-07	0	0	0	None	I	None
18168	3	G/R	rs2054202979	0.2313	gnomAD-3.1.2	3	None	0.9364	0.8865	27.4	N	None	0.42	0.011457	-1.059	0.4543	-0.0633	0.506463245118	3.25	1.0	0.534	0.691195176727	1.0	0.844765901566	-6.1	0.522	0.829	0.004	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	I	None
18168	3	G/R	rs2054202979	0.2313	gnomAD-4.0.0	3	None	0.9364	0.8865	27.4	N	None	0.42	0.011457	-1.059	0.4543	-0.0633	0.506463245118	3.25	1.0	0.534	0.691195176727	1.0	0.844765901566	-6.1	0.522	0.829	0.004	None	None	6.58207E-06	0	0	0	0	None	0	0	6.58207E-06	1.47193E-05	0	0	None	I	None
18169	4	P/H	rs2054202479	0.4462	gnomAD-3.1.2	4	None	0.4044	0.3842	33.0	N	None	0.23	0.015447	-1.392	0.4843	-0.0128	0.484536605155	3.715	1.0	0.469	0.648488047482	1.0	0.595503211021	-7.2	0.446	0.899	None	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	I	None
18169	4	P/H	rs2054202479	0.4462	gnomAD-4.0.0	4	None	0.4044	0.3842	33.0	N	None	0.23	0.015447	-1.392	0.4843	-0.0128	0.484536605155	3.715	1.0	0.469	0.648488047482	1.0	0.595503211021	-7.2	0.446	0.899	None	None	None	6.58094E-06	2.41499E-05	0	0	0	None	0	0	6.58094E-06	0	0	0	None	I	None
18169	4	P/L	None	0.4462	gnomAD-4.0.0	4	None	0.2868	0.2557	33.0	N	None	0.24	0.018224	-0.882	0.4829	0.087	0.386209809726	3.26	1.0	0.495	0.776041197187	0.987	0.604480028152	-8.03	0.446	0.882	0.002	None	None	2.05477E-06	0	0	0	0	None	0	0	2.05477E-06	1.80026E-06	0	1.65898E-05	None	I	None
18169	4	P/R	None	0.4462	gnomAD-4.0.0	4	None	0.2907	0.2864	33.0	N	None	0.29	0.011033	-0.696	0.4402	-0.1562	0.44446215622	2.065	1.0	0.532	0.600640161457	0.997	0.599406123161	-7.1	0.45	0.891	0.002	None	None	6.84925E-07	0	0	0	0	None	1.87498E-05	0	6.84925E-07	0	0	0	None	I	None
18171	6	G/R	rs751216891	0.2619	gnomAD-2.1.1	6	None	0.3919	0.3782	24.1	N	-1.01	0.48	0.015475	-1.074	0.205	-0.7531	0.380714261292	1.03	0.992909	0.405	0.494232246516	0.964	0.706580162048	-3.7	0.209	0.773	0.58	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.92E-06	0	None	N	None
18171	6	G/R	rs751216891	0.2619	gnomAD-4.0.0	6	None	0.3919	0.3782	24.1	N	-1.01	0.48	0.015475	-1.074	0.205	-0.7531	0.380714261292	1.03	0.992909	0.405	0.494232246516	0.964	0.706580162048	-3.7	0.209	0.773	0.58	None	None	3.42444E-06	0	0	0	0	None	0	0	3.42444E-06	4.50055E-06	0	0	None	N	None
18172	7	K/T	rs1236991246	0.3447	gnomAD-2.1.1	7	None	0.2614	0.2176	28.6	N	-0.084	0.42	0.01547	-0.448	0.2454	-0.5919	0.504634987189	1.605	0.999972	0.42	0.384752662912	1.0	0.786492109299	-4.2	0.319	0.781	0.149	None	None	4.04E-06	0	0	0	0	None	3.27E-05	None	4.04E-06	0	0	0	None	N	None
18172	7	K/T	rs1236991246	0.3447	gnomAD-3.1.2	7	None	0.2614	0.2176	28.6	N	-0.084	0.42	0.01547	-0.448	0.2454	-0.5919	0.504634987189	1.605	0.999972	0.42	0.384752662912	1.0	0.786492109299	-4.2	0.319	0.781	0.149	None	None	6.58E-06	0	6.56E-05	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18172	7	K/T	rs1236991246	0.3447	gnomAD-4.0.0	7	None	0.2614	0.2176	28.6	N	-0.084	0.42	0.01547	-0.448	0.2454	-0.5919	0.504634987189	1.605	0.999972	0.42	0.384752662912	1.0	0.786492109299	-4.2	0.319	0.781	0.149	None	None	3.85074E-06	0	1.69733E-05	0	2.43463E-05	None	0	0	3.85074E-06	0	1.34271E-05	0	None	N	None
18173	8	P/Q	rs794729458	0.1340	gnomAD-2.1.1	9	None	0.9899	0.9867	33.0	D	-1.331	0.35	0.012206	-1.905	0.5216	0.2402	0.440574268373	4.565	0.999999	0.477	0.576674430037	1.0	0.665457487106	-5.8	0.454	0.783	0.034	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.92E-06	0	None	N	None
18173	8	P/Q	rs794729458	0.1340	gnomAD-3.1.2	9	None	0.9899	0.9867	33.0	D	-1.331	0.35	0.012206	-1.905	0.5216	0.2402	0.440574268373	4.565	0.999999	0.477	0.576674430037	1.0	0.665457487106	-5.8	0.454	0.783	0.034	None	None	5.27E-05	2.42E-05	4.59559E-04	0	0	None	0	0	5.27E-05	0	0	0	None	N	None
18173	8	P/Q	rs794729458	0.1340	gnomAD-4.0.0	9	None	0.9899	0.9867	33.0	D	-1.331	0.35	0.012206	-1.905	0.5216	0.2402	0.440574268373	4.565	0.999999	0.477	0.576674430037	1.0	0.665457487106	-5.8	0.454	0.783	0.034	None	None	1.1167E-05	1.33797E-05	1.50331E-04	0	0	None	0	0	1.1167E-05	2.54483E-06	0	8.01693E-05	None	N	None
18173	8	P/S	rs766074604	0.1340	gnomAD-2.1.1	9	None	0.9836	0.9769	32.0	N	-1.751	0.36	0.014401	-2.581	0.4836	0.0946	0.446389955451	4.215	0.999999	0.443	0.394230963961	0.999	0.662955760956	-5.83	0.407	0.748	0.063	None	None	2.36557E-04	0	1.81663E-03	0	0	None	0	None	2.36557E-04	0	0	2.81928E-04	None	N	None
18173	8	P/S	rs766074604	0.1340	gnomAD-3.1.2	9	None	0.9836	0.9769	32.0	N	-1.751	0.36	0.014401	-2.581	0.4836	0.0946	0.446389955451	4.215	0.999999	0.443	0.394230963961	0.999	0.662955760956	-5.83	0.407	0.748	0.063	None	None	5.27E-05	0	5.25003E-04	0	0	None	0	0	5.27E-05	0	0	0	None	N	None
18173	8	P/S	rs766074604	0.1340	gnomAD-4.0.0	9	None	0.9836	0.9769	32.0	N	-1.751	0.36	0.014401	-2.581	0.4836	0.0946	0.446389955451	4.215	0.999999	0.443	0.394230963961	0.999	0.662955760956	-5.83	0.407	0.748	0.063	None	None	9.62894E-05	0	1.25624E-03	0	0	None	0	0	9.62894E-05	0	0	2.85111E-05	None	N	None
18174	9	K/N	None	0.7828	gnomAD-3.1.2	11	None	0.3818	0.3014	22.6	N	None	0.31	0.029754	0.006	0.1701	-0.8183	0.105121137339	1.83	0.772374	0.451	0.154104182512	0.055	0.524366617203	-2.69	0.077	0.467	0.042	None	None	6.58E-06	0	0	0	1.94401E-04	None	0	0	6.58E-06	0	0	0	None	N	None
18174	9	K/N	None	0.7828	gnomAD-4.0.0	11	None	0.3818	0.3014	22.6	N	None	0.31	0.029754	0.006	0.1701	-0.8183	0.105121137339	1.83	0.772374	0.451	0.154104182512	0.055	0.524366617203	-2.69	0.077	0.467	0.042	None	None	1.24062E-06	0	0	0	2.23654E-05	None	0	0	1.24062E-06	8.48228E-07	0	0	None	N	None
18175	10	V/I	rs776320086	0.2958	gnomAD-2.1.1	12	None	0.0902	0.0829	22.6	N	-0.547	0.26	0.013515	-0.574	0.0929	-1.0083	0.0693580137507	0.565	0.993186	0.53	0.280987212366	0.003	0.571933507919	-0.37	0.121	0.178	0.369	None	None	8.07E-06	0	0	0	0	None	0	None	8.07E-06	4.66E-05	8.92E-06	0	None	N	None
18175	10	V/I	rs776320086	0.2958	gnomAD-4.0.0	12	None	0.0902	0.0829	22.6	N	-0.547	0.26	0.013515	-0.574	0.0929	-1.0083	0.0693580137507	0.565	0.993186	0.53	0.280987212366	0.003	0.571933507919	-0.37	0.121	0.178	0.369	None	None	5.4788E-06	0	0	0	0	None	0	0	5.4788E-06	5.40052E-06	0	3.31708E-05	None	N	None
18175	10	V/L	None	0.2958	gnomAD-4.0.0	12	None	0.4302	0.3748	22.8	N	None	0.25	0.009378	-0.574	0.128	-0.9496	0.101652822603	1.68	0.997968	0.595	0.404733080969	0.075	0.69645100832	-1.9	0.132	0.429	0.037	None	None	1.3697E-06	0	0	0	0	None	0	0	1.3697E-06	1.80017E-06	0	0	None	N	None
18176	11	L/F	rs553262724	0.5981	gnomAD-2.1.1	13	None	0.1883	0.1257	23.4	N	-0.921	0.37	0.028256	-0.463	0.1438	-0.8111	0.265924816147	1.3	0.63856	0.44	0.536804958393	0.934	0.588126838207	-2.6	0.101	0.659	0.206	None	None	3.19E-05	1.14863E-04	0	0	0	None	0	None	3.19E-05	0	0	0	None	N	None
18176	11	L/F	rs553262724	0.5981	gnomAD-3.1.2	13	None	0.1883	0.1257	23.4	N	-0.921	0.37	0.028256	-0.463	0.1438	-0.8111	0.265924816147	1.3	0.63856	0.44	0.536804958393	0.934	0.588126838207	-2.6	0.101	0.659	0.206	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18176	11	L/F	rs553262724	0.5981	gnomAD-4.0.0	13	None	0.1883	0.1257	23.4	N	-0.921	0.37	0.028256	-0.463	0.1438	-0.8111	0.265924816147	1.3	0.63856	0.44	0.536804958393	0.934	0.588126838207	-2.6	0.101	0.659	0.206	None	None	4.34202E-06	9.34829E-05	0	0	0	None	0	0	4.34202E-06	0	0	0	None	N	None
18176	11	L/M	rs1211482141	0.5981	gnomAD-2.1.1	13	None	0.0999	0.0933	23.8	N	-0.566	0.39	0.00969	-0.474	0.1497	-0.9544	0.315989512399	0.98	0.993014	0.387	0.371344866733	0.934	0.577766597271	-1.2	0.134	0.607	0.22	None	None	4.04E-06	6.47E-05	0	0	0	None	0	None	4.04E-06	0	0	0	None	N	None
18176	11	L/M	rs1211482141	0.5981	gnomAD-3.1.2	13	None	0.0999	0.0933	23.8	N	-0.566	0.39	0.00969	-0.474	0.1497	-0.9544	0.315989512399	0.98	0.993014	0.387	0.371344866733	0.934	0.577766597271	-1.2	0.134	0.607	0.22	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18176	11	L/M	rs1211482141	0.5981	gnomAD-4.0.0	13	None	0.0999	0.0933	23.8	N	-0.566	0.39	0.00969	-0.474	0.1497	-0.9544	0.315989512399	0.98	0.993014	0.387	0.371344866733	0.934	0.577766597271	-1.2	0.134	0.607	0.22	None	None	2.48116E-06	5.34759E-05	0	0	0	None	0	0	2.48116E-06	0	0	0	None	N	None
18176	11	L/S	None	0.5981	gnomAD-4.0.0	13	None	0.181	0.1357	23.9	N	None	0.62	0.01768	-0.908	0.0785	-0.966	0.122251882449	-0.51	0.526743	0.327	0.47185959272	0.022	0.600490987301	-3.33	0.187	0.304	0.932	None	None	1.3697E-06	0	0	0	0	None	0	0	1.3697E-06	1.80019E-06	0	0	None	N	None
18177	12	A/P	rs373546809	0.4266	gnomAD-2.1.1	14	None	0.7234	0.7033	None	N	-0.4	None	None	-0.355	None	None	None	None	None	None	None	0.003	None	None	0.164	0.316	None	None	None	4.04E-06	6.47E-05	0	0	0	None	0	None	4.04E-06	0	0	0	None	N	None
18177	12	A/P	rs373546809	0.4266	gnomAD-3.1.2	14	None	0.7234	0.7033	None	N	-0.4	None	None	-0.355	None	None	None	None	None	None	None	0.003	None	None	0.164	0.316	None	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18177	12	A/P	rs373546809	0.4266	gnomAD-4.0.0	14	None	0.7234	0.7033	None	N	-0.4	None	None	-0.355	None	None	None	None	None	None	None	0.003	None	None	0.164	0.316	None	None	None	6.58233E-06	2.41604E-05	0	0	0	None	0	0	6.58233E-06	0	0	0	None	N	None
18177	12	A/T	None	0.4266	gnomAD-4.0.0	14	None	0.0922	0.0791	22.2	N	None	0.38	0.074857	-0.974	0.1385	-0.8316	0.0809002040292	0.655	0.754464	0.314	0.21279746466	0.001	0.438946157694	-0.81	0.143	0.243	0.335	None	None	1.59486E-06	0	2.29053E-05	0	0	None	0	0	1.59486E-06	0	0	0	None	N	None
18177	12	A/V	None	0.4266	gnomAD-4.0.0	14	None	0.1561	0.1302	23.6	N	None	0.37	0.066246	-0.355	0.1539	-0.7661	0.0831900980906	1.045	0.560144	0.369	0.234412748748	0.001	0.431810706854	-1.76	0.13	0.288	0.153	None	None	1.59478E-06	0	0	0	0	None	0	0	1.59478E-06	2.86467E-06	0	0	None	N	None
18178	13	R/C	rs554701601	0.5437	gnomAD-2.1.1	15	None	0.16	0.1147	24.2	N	-0.893	0.38	0.009043	-0.667	0.1153	-0.9999	0.118115022624	0.6	0.982507	0.549	0.264081493735	0.031	0.57851934433	-5.4	0.19	0.272	0.207	None	None	2.51E-05	0	2.84E-05	0	0	None	6.56E-05	None	2.51E-05	0	3.14E-05	0	None	N	None
18178	13	R/C	rs554701601	0.5437	gnomAD-3.1.2	15	None	0.16	0.1147	24.2	N	-0.893	0.38	0.009043	-0.667	0.1153	-0.9999	0.118115022624	0.6	0.982507	0.549	0.264081493735	0.031	0.57851934433	-5.4	0.19	0.272	0.207	None	None	2.63E-05	0	6.56E-05	0	0	None	0	0	2.63E-05	2.94E-05	2.06782E-04	0	None	N	None
18178	13	R/C	rs554701601	0.5437	1000 genomes	15	None	0.16	0.1147	24.2	N	-0.893	0.38	0.009043	-0.667	0.1153	-0.9999	0.118115022624	0.6	0.982507	0.549	0.264081493735	0.031	0.57851934433	-5.4	0.19	0.272	0.207	None	None	3.99361E-04	0	1.4E-03	None	0	0	None	None	3.99361E-04	None	1E-03	None	None	N	None
18178	13	R/C	rs554701601	0.5437	gnomAD-4.0.0	15	None	0.16	0.1147	24.2	N	-0.893	0.38	0.009043	-0.667	0.1153	-0.9999	0.118115022624	0.6	0.982507	0.549	0.264081493735	0.031	0.57851934433	-5.4	0.19	0.272	0.207	None	None	2.48118E-05	0	3.34024E-05	0	2.23684E-05	None	0	0	2.48118E-05	2.71435E-05	5.50031E-05	0	None	N	None
18178	13	R/G	None	0.5437	gnomAD-4.0.0	15	None	0.3275	0.1937	23.7	N	None	0.38	0.020052	-1.134	0.1506	-0.8122	0.223669715511	1.26	0.849172	0.543	0.347659731818	0.82	0.48699131608	-4.53	0.205	0.435	0.297	None	None	6.84881E-07	0	0	0	0	None	1.87406E-05	0	6.84881E-07	0	0	0	None	N	None
18178	13	R/H	rs879023208	0.5437	gnomAD-2.1.1	15	None	0.1346	0.084	None	N	-1.74	None	None	-1.487	None	None	None	None	None	None	None	0.031	None	None	0.146	0.185	None	None	None	4.04E-06	0	0	1.0022E-04	0	None	0	None	4.04E-06	0	0	0	None	N	None
18178	13	R/H	rs879023208	0.5437	gnomAD-3.1.2	15	None	0.1346	0.084	None	N	-1.74	None	None	-1.487	None	None	None	None	None	None	None	0.031	None	None	0.146	0.185	None	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18178	13	R/H	rs879023208	0.5437	gnomAD-4.0.0	15	None	0.1346	0.084	None	N	-1.74	None	None	-1.487	None	None	None	None	None	None	None	0.031	None	None	0.146	0.185	None	None	None	6.82426E-06	1.3374E-05	0	3.3873E-05	0	None	0	0	6.82426E-06	7.63464E-06	0	0	None	N	None
18179	14	T/A	None	0.3434	gnomAD-4.0.0	16	None	0.216	0.1562	23.8	D	None	0.2	0.0271	-0.748	0.1892	-0.6548	0.102401280911	2.23	0.857759	0.508	0.227260227426	0.201	0.62271130085	-3.43	0.147	0.354	0.096	None	None	2.05441E-06	0	0	0	0	None	0	0	2.05441E-06	2.70014E-06	0	0	None	N	None
18179	14	T/I	rs765149899	0.3434	gnomAD-2.1.1	16	None	0.7696	0.6886	23.9	N	-0.141	0.15	0.034608	-0.262	0.2594	-0.595	0.0913851807425	3.495	0.982462	0.56	0.311691414656	0.004	0.713463425636	-4.37	0.317	0.214	0.007	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.92E-06	0	None	N	None
18179	14	T/I	rs765149899	0.3434	gnomAD-4.0.0	16	None	0.7696	0.6886	23.9	N	-0.141	0.15	0.034608	-0.262	0.2594	-0.595	0.0913851807425	3.495	0.982462	0.56	0.311691414656	0.004	0.713463425636	-4.37	0.317	0.214	0.007	None	None	1.59458E-06	0	0	0	0	None	0	0	1.59458E-06	2.86431E-06	0	0	None	N	None
18180	15	K/E	None	0.4615	gnomAD-4.0.0	17	None	0.4224	0.2953	24.0	N	None	0.54	0.01961	-0.047	0.1231	-0.8545	0.176437022422	1.335	0.842353	0.455	0.240491677333	0.625	0.701451480389	-2.7	0.128	0.401	0.016	None	None	1.59444E-06	0	0	0	0	None	0	0	1.59444E-06	2.86421E-06	0	0	None	N	None
18180	15	K/R	rs1283224972	0.4615	gnomAD-2.1.1	17	None	0.0764	0.0649	23.5	N	0.139	0.41	0.008429	0.025	0.0917	-1.0357	0.0709212884731	0.445	0.949699	0.39	0.241664281697	0.005	0.643882095814	-1.63	0.077	0.073	0.4	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	0	1.66113E-04	None	N	None
18180	15	K/R	rs1283224972	0.4615	gnomAD-4.0.0	17	None	0.0764	0.0649	23.5	N	0.139	0.41	0.008429	0.025	0.0917	-1.0357	0.0709212884731	0.445	0.949699	0.39	0.241664281697	0.005	0.643882095814	-1.63	0.077	0.073	0.4	None	None	3.18897E-06	0	0	0	0	None	0	0	3.18897E-06	0	0	6.06024E-05	None	N	None
18181	16	G/E	rs776456385	0.2287	gnomAD-4.0.0	18	None	0.233	0.1668	23.9	N	None	0.45	0.011318	-1.591	0.0851	-0.8944	0.162931102648	-0.98	0.875106	0.496	0.402899589544	0.549	0.65760743618	-4.07	0.284	0.475	0.636	None	None	6.84793E-07	0	0	0	0	None	0	0	6.84793E-07	9.00051E-07	0	0	None	N	None
18181	16	G/R	rs761810379	0.2287	gnomAD-2.1.1	18	None	0.4937	0.3767	24.4	N	-0.677	0.46	0.012754	-0.716	0.0897	-0.868	0.236161927516	-0.325	0.818491	0.442	0.45882554386	0.81	0.672910928726	-4.03	0.153	0.499	0.102	None	None	8.07E-06	0	2.91E-05	0	0	None	0	None	8.07E-06	0	8.92E-06	0	None	N	None
18181	16	G/R	rs761810379	0.2287	gnomAD-3.1.2	18	None	0.4937	0.3767	24.4	N	-0.677	0.46	0.012754	-0.716	0.0897	-0.868	0.236161927516	-0.325	0.818491	0.442	0.45882554386	0.81	0.672910928726	-4.03	0.153	0.499	0.102	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18181	16	G/R	rs761810379	0.2287	gnomAD-4.0.0	18	None	0.4937	0.3767	24.4	N	-0.677	0.46	0.012754	-0.716	0.0897	-0.868	0.236161927516	-0.325	0.818491	0.442	0.45882554386	0.81	0.672910928726	-4.03	0.153	0.499	0.102	None	None	1.24051E-06	0	0	0	0	None	0	1.64908E-04	1.24051E-06	8.48186E-07	0	0	None	N	None
18181	16	G/V	rs776456385	0.2287	gnomAD-2.1.1	18	None	0.2403	0.1613	23.8	N	-0.28	0.41	0.011596	-0.595	0.1325	-0.8881	0.158261958056	1.07	0.999993	0.4	0.506613155829	0.549	0.602523267269	-4.8	0.223	0.518	0.036	None	None	8.07E-06	0	5.81E-05	0	0	None	0	None	8.07E-06	0	0	0	None	N	None
18181	16	G/V	rs776456385	0.2287	gnomAD-4.0.0	18	None	0.2403	0.1613	23.8	N	-0.28	0.41	0.011596	-0.595	0.1325	-0.8881	0.158261958056	1.07	0.999993	0.4	0.506613155829	0.549	0.602523267269	-4.8	0.223	0.518	0.036	None	None	1.36959E-06	0	4.47868E-05	0	0	None	0	0	1.36959E-06	0	0	0	None	N	None
18182	17	S/L	rs1470054004	0.2188	gnomAD-3.1.2	19	None	0.2144	0.1794	34.0	D	None	-0.04	0.027006	0.106	0.5604	0.2353	0.397649466034	3.815	0.999997	0.623	0.737862570375	0.997	0.696325600147	-4.2	0.472	0.675	0.004	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18182	17	S/L	rs1470054004	0.2188	gnomAD-4.0.0	19	None	0.2144	0.1794	34.0	D	None	-0.04	0.027006	0.106	0.5604	0.2353	0.397649466034	3.815	0.999997	0.623	0.737862570375	0.997	0.696325600147	-4.2	0.472	0.675	0.004	None	None	2.56678E-06	0	0	0	0	None	0	0	2.56678E-06	2.39737E-06	1.34271E-05	0	None	N	None
18183	18	M/I	rs1217449889	0.0947	gnomAD-2.1.1	20	None	0.722	0.6145	26.1	N	-0.515	0.57	0.019279	-0.788	0.2295	-0.62	0.474458688699	0.985	1.0	0.453	0.528811570836	0.985	0.788067400455	-3.07	0.39	0.611	0.257	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	N	None
18183	18	M/I	rs1217449889	0.0947	gnomAD-3.1.2	20	None	0.722	0.6145	26.1	N	-0.515	0.57	0.019279	-0.788	0.2295	-0.62	0.474458688699	0.985	1.0	0.453	0.528811570836	0.985	0.788067400455	-3.07	0.39	0.611	0.257	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18183	18	M/I	rs1217449889	0.0947	gnomAD-4.0.0	20	None	0.722	0.6145	26.1	N	-0.515	0.57	0.019279	-0.788	0.2295	-0.62	0.474458688699	0.985	1.0	0.453	0.528811570836	0.985	0.788067400455	-3.07	0.39	0.611	0.257	None	None	6.58085E-06	0	0	0	0	None	0	0	6.58085E-06	1.47206E-05	0	0	None	N	None
18183	18	M/V	rs1214008596	0.0947	gnomAD-3.1.2	20	None	0.2431	0.1851	24.8	N	None	0.64	0.020731	-1.216	0.1378	-0.6285	0.455994801244	-0.06	0.999986	0.537	0.504480301252	0.985	0.749987006187	-3.1	0.434	0.495	0.211	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18183	18	M/V	rs1214008596	0.0947	gnomAD-4.0.0	20	None	0.2431	0.1851	24.8	N	None	0.64	0.020731	-1.216	0.1378	-0.6285	0.455994801244	-0.06	0.999986	0.537	0.504480301252	0.985	0.749987006187	-3.1	0.434	0.495	0.211	None	None	6.57929E-06	0	0	0	0	None	0	0	6.57929E-06	1.47206E-05	0	0	None	N	None
18187	22	W/C	rs2054184713	0.1264	gnomAD-3.1.2	24	None	0.9946	0.993	31.0	D	None	-2.1	0.163253	-2.003	0.8929	0.9919	0.580146131267	4.515	1.0	0.869	0.707629541401	1.0	0.846804201603	-10.4	0.669	0.818	None	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18187	22	W/C	rs2054184713	0.1264	gnomAD-4.0.0	24	None	0.9946	0.993	31.0	D	None	-2.1	0.163253	-2.003	0.8929	0.9919	0.580146131267	4.515	1.0	0.869	0.707629541401	1.0	0.846804201603	-10.4	0.669	0.818	None	None	None	6.58042E-06	2.41453E-05	0	0	0	None	0	0	6.58042E-06	0	0	0	None	N	None
18187	22	W/G	rs796392077	0.1264	gnomAD-2.1.1	24	None	0.9834	0.974	29.3	D	-3.32	-2.1	0.152561	-3.847	0.8832	1.0342	0.615072577956	4.86	1.0	0.887	0.765374676318	1.0	0.825521051884	-10.4	0.831	0.82	None	None	None	3.19E-05	1.14837E-04	0	0	0	None	0	None	3.19E-05	0	0	0	None	N	None
18187	22	W/G	rs796392077	0.1264	gnomAD-3.1.2	24	None	0.9834	0.974	29.3	D	-3.32	-2.1	0.152561	-3.847	0.8832	1.0342	0.615072577956	4.86	1.0	0.887	0.765374676318	1.0	0.825521051884	-10.4	0.831	0.82	None	None	None	1.32E-05	4.83E-05	0	0	0	None	0	0	1.32E-05	0	0	0	None	N	None
18187	22	W/G	rs796392077	0.1264	gnomAD-4.0.0	24	None	0.9834	0.974	29.3	D	-3.32	-2.1	0.152561	-3.847	0.8832	1.0342	0.615072577956	4.86	1.0	0.887	0.765374676318	1.0	0.825521051884	-10.4	0.831	0.82	None	None	None	3.04529E-06	5.24347E-05	0	0	0	None	0	0	3.04529E-06	0	0	0	None	N	None
18188	23	T/I	None	0.5605	gnomAD-4.0.0	25	None	0.1542	0.1261	28.0	N	None	0.29	0.011924	-0.248	0.2126	-0.707	0.326578704726	0.82	0.793175	0.429	0.453401982733	0.966	0.564033448696	-3.73	0.276	0.586	0.082	None	None	1.59411E-06	0	0	0	0	None	1.88352E-05	0	1.59411E-06	0	0	0	None	N	None
18188	23	T/N	None	0.5605	gnomAD-4.0.0	25	None	0.0908	0.0761	24.8	N	None	0.35	0.009746	-0.832	0.1306	-0.867	0.22425734079	0.12	0.806185	0.311	0.346085882481	0.801	0.540299892426	-2.27	0.172	0.419	0.448	None	None	1.59411E-06	0	0	0	0	None	0	0	1.59411E-06	2.86395E-06	0	0	None	N	None
18188	23	T/S	None	0.5605	gnomAD-4.0.0	25	None	0.0951	0.0881	24.4	N	None	0.47	0.011857	-1.152	0.086	-0.9338	0.121489232301	0.135	0.711658	0.317	0.203808441222	0.625	0.493519216776	-1.87	0.104	0.443	0.403	None	None	1.59411E-06	0	0	0	0	None	0	0	1.59411E-06	2.86395E-06	0	0	None	N	None
18189	24	P/T	rs2054184050	0.4581	gnomAD-3.1.2	26	None	0.2392	0.2047	25.4	N	None	0.11	0.016242	-1.781	0.4383	-0.1965	0.48919594472	2.825	1.0	0.561	0.509168631294	1.0	0.68373388052	-6.4	0.443	0.874	0.019	None	None	6.58E-06	0	6.55E-05	0	0	None	0	0	6.58E-06	0	0	0	None	I	None
18189	24	P/T	rs2054184050	0.4581	gnomAD-4.0.0	26	None	0.2392	0.2047	25.4	N	None	0.11	0.016242	-1.781	0.4383	-0.1965	0.48919594472	2.825	1.0	0.561	0.509168631294	1.0	0.68373388052	-6.4	0.443	0.874	0.019	None	None	2.03023E-06	0	6.15764E-05	0	0	None	0	0	2.03023E-06	0	0	3.40298E-05	None	I	None
18193	28	N/S	rs777505893	0.4162	gnomAD-2.1.1	30	None	0.1353	0.0991	25.0	N	-0.556	0.53	0.013654	-0.571	0.1264	-0.92	0.0955349259462	0.965	0.999622	0.367	0.195762928549	0.489	0.50388610363	-3.2	0.133	0.248	0.08	None	None	4.03E-05	0	0	0	0	None	0	None	4.03E-05	0	8.92E-05	0	None	I	None
18193	28	N/S	rs777505893	0.4162	gnomAD-3.1.2	30	None	0.1353	0.0991	25.0	N	-0.556	0.53	0.013654	-0.571	0.1264	-0.92	0.0955349259462	0.965	0.999622	0.367	0.195762928549	0.489	0.50388610363	-3.2	0.133	0.248	0.08	None	None	1.97E-05	0	0	0	0	None	0	0	1.97E-05	4.41E-05	0	0	None	I	None
18193	28	N/S	rs777505893	0.4162	gnomAD-4.0.0	30	None	0.1353	0.0991	25.0	N	-0.556	0.53	0.013654	-0.571	0.1264	-0.92	0.0955349259462	0.965	0.999622	0.367	0.195762928549	0.489	0.50388610363	-3.2	0.133	0.248	0.08	None	None	4.89916E-05	1.33622E-05	0	0	0	None	0	0	4.89916E-05	6.36097E-05	1.09917E-05	3.20461E-05	None	I	None
18194	29	G/D	rs201802447	0.3657	gnomAD-2.1.1	31	None	0.9927	0.9837	None	N	-0.904	None	None	-0.831	None	None	None	None	None	None	None	1.0	None	None	0.491	0.833	None	None	None	7.16E-05	4.14E-05	0	0	0	None	0	None	7.16E-05	0	1.4895E-04	0	None	I	None
18194	29	G/D	rs201802447	0.3657	gnomAD-3.1.2	31	None	0.9927	0.9837	None	N	-0.904	None	None	-0.831	None	None	None	None	None	None	None	1.0	None	None	0.491	0.833	None	None	None	5.26E-05	0	0	0	0	None	0	0	5.26E-05	1.17716E-04	0	0	None	I	None
18194	29	G/D	rs201802447	0.3657	gnomAD-4.0.0	31	None	0.9927	0.9837	None	N	-0.904	None	None	-0.831	None	None	None	None	None	None	None	1.0	None	None	0.491	0.833	None	None	None	7.31786E-05	1.33626E-05	0	0	0	None	0	1.64799E-04	7.31786E-05	9.49917E-05	0	6.41005E-05	None	I	None
18194	29	G/S	None	0.3657	gnomAD-4.0.0	31	None	0.9354	0.8523	27.0	N	None	0.46	0.006209	-0.408	0.4439	-0.1064	0.463496485926	3.37	1.0	0.567	0.310147130316	1.0	0.74887740612	-4.8	0.486	0.814	None	None	None	1.20032E-06	6.33473E-05	0	0	0	None	0	0	1.20032E-06	0	0	0	None	I	None
18195	30	G/S	rs2054179912	0.6759	gnomAD-4.0.0	32	None	0.5142	0.3574	24.6	N	None	-0.1	0.01827	-0.395	0.4956	-0.0518	0.463496485926	2.92	1.0	0.378	0.371903410333	1.0	0.638302206993	-4.8	0.413	0.703	None	None	None	3.18767E-06	0	0	0	5.55617E-05	None	0	0	3.18767E-06	0	0	0	None	I	None
18196	31	S/P	None	0.2441	gnomAD-4.0.0	33	None	0.9857	0.9739	23.2	D	None	0.26	0.032868	-0.235	0.4471	-0.0201	0.439276402373	4.42	0.999795	0.517	0.319970858106	0.983	0.618068099022	-3.88	0.458	0.661	0.007	None	None	1.59371E-06	0	0	0	0	None	0	0	1.59371E-06	0	1.43451E-05	0	None	I	None
18197	32	P/A	rs1475050139	0.7200	gnomAD-3.1.2	34	None	0.0921	0.078	23.3	N	None	0.29	0.014166	-0.342	0.1753	-0.8833	0.0855686498455	1.985	0.968588	0.602	0.1749357433	0.026	0.655018627644	-4.6	0.194	0.191	0.058	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	I	None
18197	32	P/A	rs1475050139	0.7200	gnomAD-4.0.0	34	None	0.0921	0.078	23.3	N	None	0.29	0.014166	-0.342	0.1753	-0.8833	0.0855686498455	1.985	0.968588	0.602	0.1749357433	0.026	0.655018627644	-4.6	0.194	0.191	0.058	None	None	6.58189E-06	0	0	0	0	None	0	0	6.58189E-06	1.47167E-05	0	0	None	I	None
18197	32	P/S	rs1475050139	0.7200	gnomAD-4.0.0	34	None	0.1526	0.1247	24.0	N	None	0.29	0.017776	-0.283	0.2248	-0.6424	0.21363709283	2.29	0.98245	0.525	0.235664433957	0.811	0.662850618362	-4.43	0.281	0.442	0.161	None	None	1.59361E-06	0	0	0	0	None	0	0	1.59361E-06	2.86331E-06	0	0	None	I	None
18198	33	I/T	rs745885044	0.2323	gnomAD-2.1.1	35	None	0.9762	0.959	28.4	N	-2.196	0.03	0.026987	-2.128	0.5135	0.1489	0.51877166463	3.52	1.0	0.635	0.749689913766	1.0	0.809562623501	-4.13	0.539	0.838	0.002	None	None	4.03E-06	0	0	0	0	None	3.27E-05	None	4.03E-06	0	0	0	None	I	None
18198	33	I/T	rs745885044	0.2323	gnomAD-4.0.0	35	None	0.9762	0.959	28.4	N	-2.196	0.03	0.026987	-2.128	0.5135	0.1489	0.51877166463	3.52	1.0	0.635	0.749689913766	1.0	0.809562623501	-4.13	0.539	0.838	0.002	None	None	1.59357E-06	0	0	0	0	None	0	0	1.59357E-06	0	1.43447E-05	0	None	I	None
18198	33	I/V	None	0.2323	gnomAD-4.0.0	35	None	0.1271	0.0941	24.4	N	None	0.21	0.008748	-1.477	0.3434	-0.3785	0.422359933901	0.915	0.999999	0.62	0.549755530797	0.993	0.62883490324	-0.83	0.283	0.373	0.266	None	None	2.73854E-06	0	0	0	0	None	0	0	2.73854E-06	3.59984E-06	0	0	None	I	None
18200	35	G/D	None	0.1136	gnomAD-4.0.0	37	None	0.96	0.946	27.1	N	None	0.14	0.031066	-1.506	0.4468	-0.1503	0.527275360279	2.925	1.0	0.696	0.500050830518	1.0	0.897149085999	-5.33	0.599	0.849	0.027	None	None	1.59345E-06	0	0	0	0	None	0	0	1.59345E-06	0	1.43443E-05	0	None	N	None
18201	36	Y/H	rs779191742	0.1494	gnomAD-2.1.1	38	None	0.9834	0.9754	33.0	D	-2.813	-1.46	0.078178	-2.455	0.8114	0.9163	0.52537510995	4.835	1.0	0.758	0.750328341064	1.0	0.883993923664	-4.07	0.811	0.835	None	None	None	8.06E-06	0	0	0	0	None	0	None	8.06E-06	0	1.78E-05	0	None	N	None
18201	36	Y/H	rs779191742	0.1494	gnomAD-4.0.0	38	None	0.9834	0.9754	33.0	D	-2.813	-1.46	0.078178	-2.455	0.8114	0.9163	0.52537510995	4.835	1.0	0.758	0.750328341064	1.0	0.883993923664	-4.07	0.811	0.835	None	None	None	4.77992E-06	0	0	0	0	None	0	0	4.77992E-06	8.58821E-06	0	0	None	N	None
18202	37	W/C	rs1476258275	0.1935	gnomAD-2.1.1	39	None	0.896	0.8832	31.0	N	-1.636	0.44	0.023368	-1.775	0.2891	-0.5787	0.580146131267	1.165	1.0	0.535	0.333154297509	1.0	0.851925969124	-9.87	0.409	0.787	0.104	None	None	4.03E-06	0	2.9E-05	0	0	None	0	None	4.03E-06	0	0	0	None	N	None
18202	37	W/C	rs1476258275	0.1935	gnomAD-4.0.0	39	None	0.896	0.8832	31.0	N	-1.636	0.44	0.023368	-1.775	0.2891	-0.5787	0.580146131267	1.165	1.0	0.535	0.333154297509	1.0	0.851925969124	-9.87	0.409	0.787	0.104	None	None	1.59335E-06	0	2.28739E-05	0	0	None	0	0	1.59335E-06	0	0	0	None	N	None
18202	37	W/R	None	0.1935	gnomAD-4.0.0	39	None	0.9678	0.9575	33.0	N	None	0.61	0.027097	-1.661	0.1985	-0.6962	0.615612516959	1.01	1.0	0.504	0.606415853132	1.0	0.870254397392	-10.7	0.489	0.829	0.195	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	0	3.66327E-05	None	N	None
18203	38	L/P	rs771560830	0.0938	gnomAD-2.1.1	40	None	0.9954	0.9956	31.0	N	-1.421	0.14	0.04674	-1.717	0.477	0.0866	0.58691032302	4.15	1.0	0.708	0.80784574723	1.0	0.784271001816	-5.67	0.71	0.933	0.001	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.91E-06	0	None	N	None
18203	38	L/P	rs771560830	0.0938	gnomAD-4.0.0	40	None	0.9954	0.9956	31.0	N	-1.421	0.14	0.04674	-1.717	0.477	0.0866	0.58691032302	4.15	1.0	0.708	0.80784574723	1.0	0.784271001816	-5.67	0.71	0.933	0.001	None	None	4.78005E-06	0	0	0	0	None	0	0	4.78005E-06	8.58846E-06	0	0	None	N	None
18203	38	L/V	None	0.0938	gnomAD-4.0.0	40	None	0.2499	0.2147	23.9	N	None	0.95	0.020175	-1.717	0.1257	-0.9342	0.465770963553	0.795	0.998439	0.444	0.388495093706	0.999	0.658133268356	-2.23	0.203	0.589	0.307	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
18204	39	E/G	rs778173480	0.1341	gnomAD-4.0.0	41	None	0.9509	0.9398	None	N	-1.901	None	None	-1.696	None	None	None	None	None	None	None	0.946	None	None	0.415	0.761	None	None	None	1.5949E-05	0	0	0	0	None	1.14025E-04	0	1.5949E-05	5.7262E-06	0	6.06796E-05	None	N	None
18204	39	E/Q	rs749849370	0.1341	gnomAD-2.1.1	41	None	0.7583	0.7385	24.2	N	-1.274	0.4	0.035661	-1.302	0.2238	-0.6516	0.26318994308	2.19	0.999998	0.506	0.260249123532	0.716	0.408537477255	-2.5	0.32	0.725	0.005	None	None	1.21E-05	0	0	0	0	None	0	None	1.21E-05	0	2.67E-05	0	None	N	None
18204	39	E/Q	rs749849370	0.1341	gnomAD-3.1.2	41	None	0.7583	0.7385	24.2	N	-1.274	0.4	0.035661	-1.302	0.2238	-0.6516	0.26318994308	2.19	0.999998	0.506	0.260249123532	0.716	0.408537477255	-2.5	0.32	0.725	0.005	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18204	39	E/Q	rs749849370	0.1341	gnomAD-4.0.0	41	None	0.7583	0.7385	24.2	N	-1.274	0.4	0.035661	-1.302	0.2238	-0.6516	0.26318994308	2.19	0.999998	0.506	0.260249123532	0.716	0.408537477255	-2.5	0.32	0.725	0.005	None	None	6.82064E-06	0	1.66817E-05	0	0	None	0	0	6.82064E-06	7.63237E-06	1.09888E-05	0	None	N	None
18204	39	E/V	rs778173480	0.1341	gnomAD-2.1.1	41	None	0.96	0.9548	29.9	N	None	0.3	0.039279	-0.479	0.4437	0.0582	0.396434436232	3.67	1.0	0.573	0.539970339866	0.946	0.393623948097	-5.67	0.532	0.793	0.001	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.93E-06	0	None	N	None
18204	39	E/V	rs778173480	0.1341	gnomAD-4.0.0	41	None	0.96	0.9548	29.9	N	None	0.3	0.039279	-0.479	0.4437	0.0582	0.396434436232	3.67	1.0	0.573	0.539970339866	0.946	0.393623948097	-5.67	0.532	0.793	0.001	None	None	1.59476E-06	0	0	0	0	None	0	0	1.59476E-06	2.86303E-06	0	0	None	N	None
18206	41	R/T	None	0.2081	gnomAD-4.0.0	43	None	0.8367	0.71	22.8	N	None	0.3	0.056456	-1.815	0.2493	-0.6289	0.129148477144	2.48	0.999424	0.695	0.312001716656	0.003	0.699716210365	-4.7	0.371	0.309	0.004	None	None	1.59315E-06	0	0	0	0	None	0	0	1.59315E-06	0	0	3.02792E-05	None	N	None
18207	42	E/K	None	0.3947	gnomAD-4.0.0	44	None	0.5865	0.4872	25.2	N	None	0.39	0.04845	-0.379	0.159	-0.898	0.105021085623	1.62	0.999995	0.593	0.31291088546	0.016	0.650099813938	-3.27	0.26	0.237	0.011	None	None	1.59316E-06	0	0	0	0	None	0	0	1.59316E-06	0	0	3.02755E-05	None	N	None
18208	43	E/K	rs575533984	0.4503	gnomAD-2.1.1	50	None	0.2286	0.1646	25.3	N	-0.419	0.46	0.031236	-0.222	0.0752	-0.9308	0.0946223505276	-0.95	0.783589	0.539	0.221734844693	0.001	0.466902762651	-1.67	0.253	0.131	0.792	None	None	1.61E-05	0	0	0	0	None	9.81E-05	None	1.61E-05	0	0	1.65837E-04	None	N	None
18208	43	E/K	rs575533984	0.4503	gnomAD-3.1.2	50	None	0.2286	0.1646	25.3	N	-0.419	0.46	0.031236	-0.222	0.0752	-0.9308	0.0946223505276	-0.95	0.783589	0.539	0.221734844693	0.001	0.466902762651	-1.67	0.253	0.131	0.792	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	0	2.06954E-04	0	None	N	None
18208	43	E/K	rs575533984	0.4503	1000 genomes	50	None	0.2286	0.1646	25.3	N	-0.419	0.46	0.031236	-0.222	0.0752	-0.9308	0.0946223505276	-0.95	0.783589	0.539	0.221734844693	0.001	0.466902762651	-1.67	0.253	0.131	0.792	None	None	1.99681E-04	0	0	None	0	0	None	None	1.99681E-04	None	1E-03	None	None	N	None
18208	43	E/K	rs575533984	0.4503	gnomAD-4.0.0	50	None	0.2286	0.1646	25.3	N	-0.419	0.46	0.031236	-0.222	0.0752	-0.9308	0.0946223505276	-0.95	0.783589	0.539	0.221734844693	0.001	0.466902762651	-1.67	0.253	0.131	0.792	None	None	6.20001E-06	0	1.66744E-05	0	0	None	0	0	6.20001E-06	1.6961E-06	7.6918E-05	0	None	N	None
18210	45	S/I	None	0.2420	gnomAD-4.0.0	60	None	0.2441	0.2021	23.8	N	None	0.38	0.070997	-0.117	0.2123	-0.7534	0.109647489006	2.74	0.634135	0.456	0.436348499334	0.055	0.359036028385	-3.02	0.196	0.363	0.029	None	None	6.84561E-07	0	0	0	0	None	0	0	6.84561E-07	8.99896E-07	0	0	None	N	None
18210	45	S/T	None	0.2420	gnomAD-4.0.0	60	None	0.1274	0.1067	23.2	N	None	0.47	0.033414	-0.513	0.1254	-0.9374	0.0765124343762	0.72	0.942285	0.352	0.193865811164	None	0.346399784088	-1.18	0.193	0.117	0.272	None	None	6.84561E-07	0	0	0	0	None	0	0	6.84561E-07	8.99896E-07	0	0	None	N	None
18211	46	P/L	rs764772164	0.6774	gnomAD-3.1.2	63	None	0.1059	0.09	21.3	N	-0.051	0.41	0.008495	-0.283	0.0819	-1.0151	0.0849186609174	0.57	0.999999	0.515	0.222439326576	None	0.354109674692	-1.52	0.088	0.215	0.34	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18211	46	P/L	rs764772164	0.6774	gnomAD-4.0.0	63	None	0.1059	0.09	21.3	N	-0.051	0.41	0.008495	-0.283	0.0819	-1.0151	0.0849186609174	0.57	0.999999	0.515	0.222439326576	None	0.354109674692	-1.52	0.088	0.215	0.34	None	None	1.86004E-06	0	1.66761E-05	0	0	None	0	0	1.86004E-06	1.69609E-06	0	0	None	N	None
18211	46	P/R	rs764772164	0.6774	gnomAD-3.1.2	63	None	0.1816	0.1452	21.1	N	None	0.39	0.006955	0.063	0.0819	-1.0151	0.0881463004909	0.67	1.0	0.479	0.126345400529	0.001	0.375794947147	-1.67	0.065	0.211	0.074	None	None	1.32E-05	0	0	0	0	None	0	0	1.32E-05	2.94E-05	0	0	None	N	None
18211	46	P/R	rs764772164	0.6774	gnomAD-4.0.0	63	None	0.1816	0.1452	21.1	N	None	0.39	0.006955	0.063	0.0819	-1.0151	0.0881463004909	0.67	1.0	0.479	0.126345400529	0.001	0.375794947147	-1.67	0.065	0.211	0.074	None	None	1.67415E-05	0	0	0	0	None	0	0	1.67415E-05	2.20491E-05	0	1.60231E-05	None	N	None
18211	46	P/S	rs727504192	0.6774	gnomAD-3.1.2	63	None	0.0875	0.0779	15.08	N	None	0.46	0.006976	-0.574	0.0467	-1.0409	0.084161567983	-0.635	1.0	0.407	0.0297737177859	None	0.321507066488	-0.12	0.067	0.161	0.141	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18211	46	P/S	rs727504192	0.6774	gnomAD-4.0.0	63	None	0.0875	0.0779	15.08	N	None	0.46	0.006976	-0.574	0.0467	-1.0409	0.084161567983	-0.635	1.0	0.407	0.0297737177859	None	0.321507066488	-0.12	0.067	0.161	0.141	None	None	6.58085E-06	2.41406E-05	0	0	0	None	0	0	6.58085E-06	0	0	0	None	N	None
18211	46	P/T	rs727504192	0.6774	gnomAD-2.1.1	63	None	0.0761	0.0672	None	N	-0.331	None	None	-0.568	None	None	None	None	None	None	None	None	None	None	0.059	0.163	None	None	None	7.86E-05	0	2.83E-05	0	0	None	0	None	7.86E-05	0	1.64317E-04	0	None	N	None
18211	46	P/T	rs727504192	0.6774	gnomAD-3.1.2	63	None	0.0761	0.0672	None	N	-0.331	None	None	-0.568	None	None	None	None	None	None	None	None	None	None	0.059	0.163	None	None	None	8.56E-05	2.41E-05	0	0	0	None	0	0	8.56E-05	1.76606E-04	0	0	None	N	None
18211	46	P/T	rs727504192	0.6774	gnomAD-4.0.0	63	None	0.0761	0.0672	None	N	-0.331	None	None	-0.568	None	None	None	None	None	None	None	None	None	None	0.059	0.163	None	None	None	2.03997E-04	8.01775E-05	0	0	0	None	0	0	2.03997E-04	2.55258E-04	0	3.52485E-04	None	N	None
18212	47	Y/F	rs772610346	0.9767	gnomAD-4.0.0	64	None	0.1036	0.1018	27.3	N	None	0.44	0.01068	-0.286	0.2865	-0.5244	0.445162184416	1.42	0.999988	0.333	0.474643619859	0.999	0.678395032883	-2.93	0.293	0.55	0.374	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
18213	48	W/S	None	0.2381	gnomAD-4.0.0	65	None	0.9909	0.9789	28.4	N	None	0.5	0.023197	-2.212	0.3968	-0.1485	0.447503794709	3.61	1.0	0.757	0.795843823839	0.942	0.718325138092	-10.8	0.474	0.681	None	None	None	1.59315E-06	0	0	0	0	None	0	0	1.59315E-06	2.86256E-06	0	0	None	N	None
18215	50	R/C	rs187167219	0.3145	gnomAD-2.1.1	67	None	0.6713	0.6442	None	N	-0.881	None	None	-0.725	None	None	None	None	None	None	None	1.0	None	None	0.383	0.703	None	None	None	6.44E-05	6.47E-05	0	0	7.24153E-04	None	0	None	6.44E-05	0	1.78E-05	0	None	N	None
18215	50	R/C	rs187167219	0.3145	gnomAD-3.1.2	67	None	0.6713	0.6442	None	N	-0.881	None	None	-0.725	None	None	None	None	None	None	None	1.0	None	None	0.383	0.703	None	None	None	1.32E-05	0	0	0	3.89864E-04	None	0	0	1.32E-05	0	0	0	None	N	None
18215	50	R/C	rs187167219	0.3145	1000 genomes	67	None	0.6713	0.6442	None	N	-0.881	None	None	-0.725	None	None	None	None	None	None	None	1.0	None	None	0.383	0.703	None	None	None	1.99681E-04	0	0	None	1E-03	0	None	None	1.99681E-04	None	0	None	None	N	None
18215	50	R/C	rs187167219	0.3145	gnomAD-4.0.0	67	None	0.6713	0.6442	None	N	-0.881	None	None	-0.725	None	None	None	None	None	None	None	1.0	None	None	0.383	0.703	None	None	None	2.04608E-05	1.33472E-05	0	0	4.91137E-04	None	0	0	2.04608E-05	7.63245E-06	0	1.60179E-05	None	N	None
18215	50	R/H	rs183010574	0.3145	gnomAD-2.1.1	67	None	0.4162	0.3883	29.2	N	-1.87	0.48	0.021102	-1.457	0.3221	-0.5168	0.503899149776	1.95	0.999968	0.501	0.342865806769	1.0	0.568345069885	-3.97	0.306	0.661	0.017	None	None	1.21E-05	0	0	0	0	None	0	None	1.21E-05	0	1.78E-05	1.65728E-04	None	N	None
18215	50	R/H	rs183010574	0.3145	gnomAD-3.1.2	67	None	0.4162	0.3883	29.2	N	-1.87	0.48	0.021102	-1.457	0.3221	-0.5168	0.503899149776	1.95	0.999968	0.501	0.342865806769	1.0	0.568345069885	-3.97	0.306	0.661	0.017	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18215	50	R/H	rs183010574	0.3145	gnomAD-4.0.0	67	None	0.4162	0.3883	29.2	N	-1.87	0.48	0.021102	-1.457	0.3221	-0.5168	0.503899149776	1.95	0.999968	0.501	0.342865806769	1.0	0.568345069885	-3.97	0.306	0.661	0.017	None	None	1.24007E-05	1.33608E-05	1.66817E-05	0	0	None	0	0	1.24007E-05	1.01764E-05	2.19713E-05	6.40902E-05	None	N	None
18215	50	R/P	rs183010574	0.3145	gnomAD-2.1.1	67	None	0.7857	0.7566	None	N	-0.756	None	None	-0.205	None	None	None	None	None	None	None	1.0	None	None	0.321	0.773	None	None	None	2.86E-05	4.14E-05	8.48E-05	0	0	None	0	None	2.86E-05	0	3.13E-05	0	None	N	None
18215	50	R/P	rs183010574	0.3145	gnomAD-3.1.2	67	None	0.7857	0.7566	None	N	-0.756	None	None	-0.205	None	None	None	None	None	None	None	1.0	None	None	0.321	0.773	None	None	None	1.32E-05	0	6.56E-05	0	0	None	0	0	1.32E-05	1.47E-05	0	0	None	N	None
18215	50	R/P	rs183010574	0.3145	1000 genomes	67	None	0.7857	0.7566	None	N	-0.756	None	None	-0.205	None	None	None	None	None	None	None	1.0	None	None	0.321	0.773	None	None	None	1.99681E-04	0	1.4E-03	None	0	0	None	None	1.99681E-04	None	0	None	None	N	None
18215	50	R/P	rs183010574	0.3145	gnomAD-4.0.0	67	None	0.7857	0.7566	None	N	-0.756	None	None	-0.205	None	None	None	None	None	None	None	1.0	None	None	0.321	0.773	None	None	None	8.67985E-06	1.3339E-05	6.67045E-05	0	0	None	0	0	8.67985E-06	7.63236E-06	0	0	None	N	None
18216	51	V/I	rs2054164910	0.2063	gnomAD-3.1.2	68	None	0.1472	0.1189	24.2	N	None	0.43	0.006179	-0.042	0.3314	-0.4938	0.420894402933	2.1	0.999999	0.396	0.630072707612	0.997	0.654202759266	-0.8	0.253	0.459	0.016	None	None	1.32E-05	0	1.31268E-04	0	0	None	0	0	1.32E-05	0	0	0	None	I	None
18216	51	V/I	rs2054164910	0.2063	gnomAD-4.0.0	68	None	0.1472	0.1189	24.2	N	None	0.43	0.006179	-0.042	0.3314	-0.4938	0.420894402933	2.1	0.999999	0.396	0.630072707612	0.997	0.654202759266	-0.8	0.253	0.459	0.016	None	None	5.13006E-06	0	5.08802E-05	0	0	None	0	0	5.13006E-06	2.39621E-06	0	0	None	I	None
18217	52	S/G	rs201001270	0.2071	gnomAD-2.1.1	69	None	0.2357	0.1927	None	N	-1.152	None	None	-0.809	None	None	None	None	None	None	None	0.454	None	None	0.221	0.367	None	None	None	2.86E-05	0	0	0	0	None	0	None	2.86E-05	0	6.26E-05	0	None	N	None
18217	52	S/G	rs201001270	0.2071	gnomAD-3.1.2	69	None	0.2357	0.1927	None	N	-1.152	None	None	-0.809	None	None	None	None	None	None	None	0.454	None	None	0.221	0.367	None	None	None	3.95E-05	0	0	0	0	None	0	0	3.95E-05	8.83E-05	0	0	None	N	None
18217	52	S/G	rs201001270	0.2071	gnomAD-4.0.0	69	None	0.2357	0.1927	None	N	-1.152	None	None	-0.809	None	None	None	None	None	None	None	0.454	None	None	0.221	0.367	None	None	None	6.51028E-05	0	0	0	0	None	0	0	6.51028E-05	8.64973E-05	0	4.80646E-05	None	N	None
18218	53	R/Q	rs143643360	1.0205	gnomAD-2.1.1	70	None	0.4992	0.3699	None	N	0.171	None	None	-0.428	None	None	None	None	None	None	None	0.993	None	None	0.31	0.601	None	None	None	1.79E-05	4.14E-05	0	0	0	None	0	None	1.79E-05	0	3.13E-05	0	None	I	None
18218	53	R/Q	rs143643360	1.0205	gnomAD-3.1.2	70	None	0.4992	0.3699	None	N	0.171	None	None	-0.428	None	None	None	None	None	None	None	0.993	None	None	0.31	0.601	None	None	None	1.32E-05	2.42E-05	0	0	0	None	9.42E-05	0	1.32E-05	0	0	0	None	I	None
18218	53	R/Q	rs143643360	1.0205	1000 genomes	70	None	0.4992	0.3699	None	N	0.171	None	None	-0.428	None	None	None	None	None	None	None	0.993	None	None	0.31	0.601	None	None	None	1.99681E-04	8E-04	0	None	0	0	None	None	1.99681E-04	None	0	None	None	I	None
18218	53	R/Q	rs143643360	1.0205	gnomAD-4.0.0	70	None	0.4992	0.3699	None	N	0.171	None	None	-0.428	None	None	None	None	None	None	None	0.993	None	None	0.31	0.601	None	None	None	2.728E-05	4.0032E-05	0	0	0	None	3.12422E-05	1.65344E-04	2.728E-05	3.22252E-05	0	0	None	I	None
18219	54	A/V	rs546735795	0.3959	gnomAD-2.1.1	72	None	0.1979	0.1618	24.5	N	0.025	0.24	0.032678	-0.258	0.1678	-0.7602	0.179791030076	0.73	0.999436	0.333	0.435479573448	0.704	0.695384144783	-2.37	0.297	0.33	0.043	None	None	4.02E-06	6.47E-05	0	0	0	None	0	None	4.02E-06	0	0	0	None	I	None
18219	54	A/V	rs546735795	0.3959	gnomAD-3.1.2	72	None	0.1979	0.1618	24.5	N	0.025	0.24	0.032678	-0.258	0.1678	-0.7602	0.179791030076	0.73	0.999436	0.333	0.435479573448	0.704	0.695384144783	-2.37	0.297	0.33	0.043	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	I	None
18219	54	A/V	rs546735795	0.3959	1000 genomes	72	None	0.1979	0.1618	24.5	N	0.025	0.24	0.032678	-0.258	0.1678	-0.7602	0.179791030076	0.73	0.999436	0.333	0.435479573448	0.704	0.695384144783	-2.37	0.297	0.33	0.043	None	None	1.99681E-04	8E-04	0	None	0	0	None	None	1.99681E-04	None	0	None	None	I	None
18219	54	A/V	rs546735795	0.3959	gnomAD-4.0.0	72	None	0.1979	0.1618	24.5	N	0.025	0.24	0.032678	-0.258	0.1678	-0.7602	0.179791030076	0.73	0.999436	0.333	0.435479573448	0.704	0.695384144783	-2.37	0.297	0.33	0.043	None	None	6.57825E-06	2.40906E-05	0	0	0	None	0	0	6.57825E-06	0	0	0	None	I	None
18221	56	I/L	rs375091820	0.1216	gnomAD-2.1.1	77	None	0.2268	0.1707	20.6	N	-0.381	0.21	0.021868	0.013	0.1372	-0.8573	0.101745481976	1.73	0.750086	0.376	0.227260227426	0.136	0.383637875319	-1.57	0.059	0.473	0.016	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
18221	56	I/L	rs375091820	0.1216	gnomAD-4.0.0	77	None	0.2268	0.1707	20.6	N	-0.381	0.21	0.021868	0.013	0.1372	-0.8573	0.101745481976	1.73	0.750086	0.376	0.227260227426	0.136	0.383637875319	-1.57	0.059	0.473	0.016	None	None	6.8451E-07	0	0	0	0	None	0	0	6.8451E-07	0	1.16007E-05	0	None	N	None
18221	56	I/T	rs1418665991	0.1216	gnomAD-2.1.1	77	None	0.7791	0.7952	24.4	N	-2.165	0.09	0.044648	-1.625	0.1761	-0.7373	0.186666295219	1.745	0.997346	0.491	0.63963811802	0.801	0.437075257301	-3.33	0.287	0.628	0.062	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
18221	56	I/T	rs1418665991	0.1216	gnomAD-4.0.0	77	None	0.7791	0.7952	24.4	N	-2.165	0.09	0.044648	-1.625	0.1761	-0.7373	0.186666295219	1.745	0.997346	0.491	0.63963811802	0.801	0.437075257301	-3.33	0.287	0.628	0.062	None	None	1.59294E-06	0	0	0	0	None	0	0	1.59294E-06	0	1.43386E-05	0	None	N	None
18221	56	I/V	rs375091820	0.1216	gnomAD-2.1.1	77	None	0.0701	0.0679	None	N	-0.972	None	None	-0.532	None	None	None	None	None	None	None	0.002	None	None	0.075	0.231	None	None	None	2.14E-05	0	8.48E-05	0	0	None	3.27E-05	None	2.14E-05	0	7.82E-06	1.40292E-04	None	N	None
18221	56	I/V	rs375091820	0.1216	gnomAD-4.0.0	77	None	0.0701	0.0679	None	N	-0.972	None	None	-0.532	None	None	None	None	None	None	None	0.002	None	None	0.075	0.231	None	None	None	1.57437E-05	0	6.70991E-05	0	2.52016E-05	None	0	0	1.57437E-05	1.16979E-05	6.9604E-05	0	None	N	None
18223	58	K/T	rs771180692	0.9802	gnomAD-2.1.1	79	None	0.4979	0.3501	25.7	N	-0.948	0.7	0.021779	-0.136	0.1885	-0.7852	0.326723134404	1.235	0.999891	0.56	0.290222751274	0.946	0.66403734684	-4.6	0.292	0.703	0.005	None	None	3.93E-05	0	0	0	0	None	0	None	3.93E-05	3.9968E-04	7.82E-06	0	None	I	None
18223	58	K/T	rs771180692	0.9802	gnomAD-3.1.2	79	None	0.4979	0.3501	25.7	N	-0.948	0.7	0.021779	-0.136	0.1885	-0.7852	0.326723134404	1.235	0.999891	0.56	0.290222751274	0.946	0.66403734684	-4.6	0.292	0.703	0.005	None	None	1.97E-05	0	0	0	0	None	2.82805E-04	0	1.97E-05	0	0	0	None	I	None
18223	58	K/T	rs771180692	0.9802	gnomAD-4.0.0	79	None	0.4979	0.3501	25.7	N	-0.948	0.7	0.021779	-0.136	0.1885	-0.7852	0.326723134404	1.235	0.999891	0.56	0.290222751274	0.946	0.66403734684	-4.6	0.292	0.703	0.005	None	None	1.11609E-05	0	0	0	0	None	2.18723E-04	0	1.11609E-05	2.54409E-06	0	1.60226E-05	None	I	None
18224	59	V/A	rs749405835	0.5990	gnomAD-2.1.1	80	None	0.1093	0.078	20.5	N	-1.112	0.48	0.005838	-0.39	0.0585	-1.032	0.100674487917	0.205	0.999146	0.448	0.306377322295	None	0.367451369762	-1.69	0.068	0.177	0.336	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	N	None
18224	59	V/A	rs749405835	0.5990	gnomAD-4.0.0	80	None	0.1093	0.078	20.5	N	-1.112	0.48	0.005838	-0.39	0.0585	-1.032	0.100674487917	0.205	0.999146	0.448	0.306377322295	None	0.367451369762	-1.69	0.068	0.177	0.336	None	None	9.55782E-06	0	0	0	0	None	0	0	9.55782E-06	1.71738E-05	0	0	None	N	None
18225	60	G/V	rs886038866	0.3035	gnomAD-4.0.0	81	None	0.2557	0.1482	25.3	N	None	0.69	0.012839	-0.332	0.2642	-0.5678	0.390242522883	2.295	0.999997	0.493	0.490213675041	0.987	0.569031715393	-5.1	0.253	0.819	0.122	None	None	9.55773E-06	0	0	0	0	None	0	0	9.55773E-06	1.71733E-05	0	0	None	N	None
18227	62	K/N	rs371332455	1.0756	gnomAD-2.1.1	83	None	0.5135	0.4496	24.1	N	-0.025	0.36	0.025965	-0.164	0.2188	-0.7977	0.500188843923	1.345	0.997216	0.586	0.233785782151	1.0	0.701469123363	-3.83	0.277	0.745	0.025	None	None	8.04E-06	0	0	0	0	None	0	None	8.04E-06	0	1.78E-05	0	None	N	None
18227	62	K/N	rs371332455	1.0756	gnomAD-4.0.0	83	None	0.5135	0.4496	24.1	N	-0.025	0.36	0.025965	-0.164	0.2188	-0.7977	0.500188843923	1.345	0.997216	0.586	0.233785782151	1.0	0.701469123363	-3.83	0.277	0.745	0.025	None	None	1.59306E-06	0	0	0	0	None	0	0	1.59306E-06	2.86239E-06	0	0	None	N	None
18228	63	G/D	rs2154194670	0.2496	gnomAD-3.1.2	88	None	0.4319	0.2936	23.6	N	None	0.31	0.042725	-0.976	0.2372	-0.5794	0.45004994787	0.855	0.999955	0.646	0.270447802918	0.946	0.711068868637	-5.06	0.369	0.754	0.107	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	I	None
18228	63	G/D	rs2154194670	0.2496	gnomAD-4.0.0	88	None	0.4319	0.2936	23.6	N	None	0.31	0.042725	-0.976	0.2372	-0.5794	0.45004994787	0.855	0.999955	0.646	0.270447802918	0.946	0.711068868637	-5.06	0.369	0.754	0.107	None	None	6.57592E-06	2.40639E-05	0	0	0	None	0	0	6.57592E-06	0	0	0	None	I	None
18229	64	V/L	rs116142642	0.0843	gnomAD-2.1.1	89	None	0.2312	0.1638	18.74	N	-0.269	0.37	0.007904	-0.165	0.0474	-1.0668	0.0827083444963	-0.615	0.888055	0.603	0.193865811164	None	0.381071656942	-1.17	0.107	0.083	0.434	None	None	2.01E-05	0	1.4486E-04	0	0	None	0	None	2.01E-05	0	0	0	None	I	None
18229	64	V/L	rs116142642	0.0843	gnomAD-4.0.0	89	None	0.2312	0.1638	18.74	N	-0.269	0.37	0.007904	-0.165	0.0474	-1.0668	0.0827083444963	-0.615	0.888055	0.603	0.193865811164	None	0.381071656942	-1.17	0.107	0.083	0.434	None	None	3.4227E-06	0	1.11842E-04	0	0	None	0	0	3.4227E-06	0	0	0	None	I	None
18229	64	V/M	rs116142642	0.0843	gnomAD-2.1.1	89	None	0.1855	0.1352	None	N	-0.349	None	None	-0.439	None	None	None	None	None	None	None	0.808	None	None	0.055	0.28	None	None	None	1.39335E-04	1.65508E-04	0	0	8.73946E-04	None	3.59501E-04	None	1.39335E-04	0	3.13E-05	4.21467E-04	None	I	None
18229	64	V/M	rs116142642	0.0843	gnomAD-3.1.2	89	None	0.1855	0.1352	None	N	-0.349	None	None	-0.439	None	None	None	None	None	None	None	0.808	None	None	0.055	0.28	None	None	None	1.11891E-04	2.41464E-04	0	0	5.83885E-04	None	0	0	1.11891E-04	5.89E-05	0	0	None	I	None
18229	64	V/M	rs116142642	0.0843	1000 genomes	89	None	0.1855	0.1352	None	N	-0.349	None	None	-0.439	None	None	None	None	None	None	None	0.808	None	None	0.055	0.28	None	None	None	5.99042E-04	8E-04	0	None	2E-03	0	None	None	5.99042E-04	None	0	None	None	I	None
18229	64	V/M	rs116142642	0.0843	gnomAD-4.0.0	89	None	0.1855	0.1352	None	N	-0.349	None	None	-0.439	None	None	None	None	None	None	None	0.808	None	None	0.055	0.28	None	None	None	6.94407E-05	2.80187E-04	0	0	5.80435E-04	None	0	0	6.94407E-05	2.20491E-05	3.07591E-04	1.76186E-04	None	I	None
18230	65	E/V	None	0.4591	gnomAD-4.0.0	90	None	0.4315	0.3138	32.0	N	None	0.25	0.047819	-0.148	0.3473	-0.3571	0.478096384883	2.08	0.999997	0.571	0.500176316166	0.999	0.50462859869	-5.3	0.473	0.849	0.027	None	None	3.60097E-06	0	0	0	0	None	0	0	3.60097E-06	3.9375E-06	0	0	None	N	None
18231	66	F/L	None	0.2282	gnomAD-4.0.0	91	None	0.9706	0.951	21.8	N	None	0.47	0.020735	-0.965	0.1356	-0.9442	0.135118669469	1.42	0.736899	0.597	0.119812018005	0.201	0.654532909393	-4.23	0.216	0.664	0.118	None	None	1.20032E-06	6.33473E-05	0	0	0	None	0	0	1.20032E-06	0	0	0	None	N	None
18233	68	V/A	None	0.1066	gnomAD-4.0.0	93	None	0.7872	0.6688	28.2	N	None	0.08	0.027146	-1.856	0.3795	-0.2621	0.504685203352	2.54	0.999999	0.578	0.562807121957	0.999	0.594666600227	-3.17	0.453	0.611	0.088	None	None	1.5933E-06	0	0	0	0	None	0	0	1.5933E-06	2.86279E-06	0	0	None	N	None
18233	68	V/D	rs1060500469	0.1066	gnomAD-3.1.2	93	None	0.9919	0.9893	29.6	N	None	0.08	0.051096	-2.564	0.4334	-0.0752	0.587031713447	3.0	1.0	0.713	0.775735391153	1.0	0.597434878349	-5.5	0.673	0.85	0.001	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18233	68	V/D	rs1060500469	0.1066	gnomAD-4.0.0	93	None	0.9919	0.9893	29.6	N	None	0.08	0.051096	-2.564	0.4334	-0.0752	0.587031713447	3.0	1.0	0.713	0.775735391153	1.0	0.597434878349	-5.5	0.673	0.85	0.001	None	None	6.5825E-06	2.41464E-05	0	0	0	None	0	0	6.5825E-06	0	0	0	None	N	None
18233	68	V/I	rs374996996	0.1066	gnomAD-2.1.1	93	None	0.1439	0.1045	None	N	-0.132	None	None	-0.2	None	None	None	None	None	None	None	0.997	None	None	0.298	0.508	None	None	None	8.05E-06	1.29416E-04	0	0	0	None	0	None	8.05E-06	0	0	0	None	N	None
18234	69	P/T	rs1060500416	0.4062	gnomAD-3.1.2	94	None	0.1984	0.114	22.6	N	None	0.59	0.007162	-1.093	0.071	-0.953	0.22060418715	-1.785	0.581584	0.507	0.305410167561	0.891	0.456549167633	-3.47	0.182	0.485	1.0	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18234	69	P/T	rs1060500416	0.4062	gnomAD-4.0.0	94	None	0.1984	0.114	22.6	N	None	0.59	0.007162	-1.093	0.071	-0.953	0.22060418715	-1.785	0.581584	0.507	0.305410167561	0.891	0.456549167633	-3.47	0.182	0.485	1.0	None	None	6.58371E-06	2.41639E-05	0	0	0	None	0	0	6.58371E-06	0	0	0	None	N	None
18235	70	R/C	rs758019427	0.7782	gnomAD-2.1.1	96	None	0.377	0.2444	27.8	N	-0.19	0.4	0.016735	-0.174	0.3747	-0.3414	0.517476731111	2.36	0.999996	0.666	0.568285537894	1.0	0.619409680367	-5.77	0.351	0.659	0.016	None	None	1.21E-05	6.47E-05	0	0	0	None	3.27E-05	None	1.21E-05	0	8.9E-06	0	None	N	None
18235	70	R/C	rs758019427	0.7782	gnomAD-4.0.0	96	None	0.377	0.2444	27.8	N	-0.19	0.4	0.016735	-0.174	0.3747	-0.3414	0.517476731111	2.36	0.999996	0.666	0.568285537894	1.0	0.619409680367	-5.77	0.351	0.659	0.016	None	None	2.73845E-06	2.99383E-05	0	0	0	None	0	0	2.73845E-06	8.99941E-07	1.16015E-05	1.65799E-05	None	N	None
18235	70	R/G	rs758019427	0.7782	gnomAD-2.1.1	96	None	0.4203	0.223	26.0	N	0.035	0.82	0.036381	-0.07	0.1448	-0.6553	0.450788619481	-1.21	0.998478	0.647	0.393471546983	0.996	0.524302244186	-4.83	0.333	0.505	0.343	None	None	8.05E-06	0	0	0	0	None	0	None	8.05E-06	0	1.78E-05	0	None	N	None
18235	70	R/G	rs758019427	0.7782	gnomAD-3.1.2	96	None	0.4203	0.223	26.0	N	0.035	0.82	0.036381	-0.07	0.1448	-0.6553	0.450788619481	-1.21	0.998478	0.647	0.393471546983	0.996	0.524302244186	-4.83	0.333	0.505	0.343	None	None	6.59E-06	0	0	0	0	None	0	0	6.59E-06	1.47E-05	0	0	None	N	None
18235	70	R/G	rs758019427	0.7782	gnomAD-4.0.0	96	None	0.4203	0.223	26.0	N	0.035	0.82	0.036381	-0.07	0.1448	-0.6553	0.450788619481	-1.21	0.998478	0.647	0.393471546983	0.996	0.524302244186	-4.83	0.333	0.505	0.343	None	None	3.10069E-06	0	0	0	0	None	0	0	3.10069E-06	4.24046E-06	0	0	None	N	None
18235	70	R/H	rs750125113	0.7782	gnomAD-2.1.1	96	None	0.1969	0.1082	24.7	N	-0.509	0.44	0.024991	-0.591	0.1249	-0.9109	0.130278000646	0.425	0.996104	0.645	0.253205268125	0.67	0.544918477535	-3.1	0.269	0.417	0.193	None	None	8.05E-06	0	0	0	0	None	6.54E-05	None	8.05E-06	0	0	0	None	N	None
18235	70	R/H	rs750125113	0.7782	gnomAD-4.0.0	96	None	0.1969	0.1082	24.7	N	-0.509	0.44	0.024991	-0.591	0.1249	-0.9109	0.130278000646	0.425	0.996104	0.645	0.253205268125	0.67	0.544918477535	-3.1	0.269	0.417	0.193	None	None	8.89995E-06	0	0	0	1.51355E-04	None	0	0	8.89995E-06	3.59978E-06	3.48044E-05	0	None	N	None
18236	71	L/F	rs1273412223	0.1348	gnomAD-2.1.1	97	None	0.908	0.841	26.0	D	-2.082	-1.91	0.014313	-1.733	0.8133	0.7852	0.482416341566	3.85	0.999717	0.782	0.856038879355	1.0	0.577704071999	-3.23	0.687	0.867	0.005	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
18236	71	L/F	rs1273412223	0.1348	gnomAD-4.0.0	97	None	0.908	0.841	26.0	D	-2.082	-1.91	0.014313	-1.733	0.8133	0.7852	0.482416341566	3.85	0.999717	0.782	0.856038879355	1.0	0.577704071999	-3.23	0.687	0.867	0.005	None	None	1.59341E-06	0	2.28739E-05	0	0	None	0	0	1.59341E-06	0	0	0	None	N	None
18236	71	L/S	None	0.1348	gnomAD-4.0.0	97	None	0.993	0.9906	33.0	D	None	-1.95	0.045382	-3.169	0.8564	0.9871	0.543900500545	4.82	0.999986	0.816	0.940916431798	1.0	0.606443047523	-4.83	0.818	0.854	0.001	None	None	2.05377E-06	8.97935E-05	0	0	0	None	0	0	2.05377E-06	0	0	0	None	N	None
18236	71	L/W	None	0.1348	gnomAD-4.0.0	97	None	0.9903	0.9794	33.0	D	None	-1.95	0.036681	-2.024	0.8564	0.9871	0.591322331779	4.475	0.99999	0.748	0.937323672544	1.0	0.656886696815	-4.83	0.764	0.789	0.001	None	None	6.84589E-07	0	0	0	0	None	0	0	6.84589E-07	0	1.16015E-05	0	None	N	None
18237	72	L/P	rs201412693	0.6850	gnomAD-2.1.1	98	None	0.4574	0.3974	None	N	-0.639	None	None	-0.634	None	None	None	None	None	None	None	0.013	None	None	0.09	0.341	None	None	None	6.42972E-04	2.06937E-04	6.22242E-04	0	0	None	0	None	6.42972E-04	1.19942E-04	1.12554E-03	8.42933E-04	None	N	None
18237	72	L/P	rs201412693	0.6850	gnomAD-3.1.2	98	None	0.4574	0.3974	None	N	-0.639	None	None	-0.634	None	None	None	None	None	None	None	0.013	None	None	0.09	0.341	None	None	None	6.12076E-04	2.41464E-04	4.59619E-04	0	0	None	9.42E-05	0	6.12076E-04	1.08926E-03	0	4.78469E-04	None	N	None
18237	72	L/P	rs201412693	0.6850	1000 genomes	98	None	0.4574	0.3974	None	N	-0.639	None	None	-0.634	None	None	None	None	None	None	None	0.013	None	None	0.09	0.341	None	None	None	7.98722E-04	0	0	None	0	4E-03	None	None	7.98722E-04	None	0	None	None	N	None
18237	72	L/P	rs201412693	0.6850	http://www.ncbi.nlm.nih.gov/pubmed/33449170;	98	CNM;	0.4574	0.3974	None	N	-0.639	None	None	-0.634	None	None	None	None	None	None	None	0.013	None	None	0.09	0.341	None	comp het with D32441Ffs1, W35453	Genetic analysis of TTN in 30 CM patients; comp het with truncating; Domain unfolded in vitro (Tm 17 degrees lower than WT)	None	None	None	None	None	None	None	None	None	None	None	None	None	N	None
18237	72	L/P	rs201412693	0.6850	gnomAD-4.0.0	98	None	0.4574	0.3974	None	N	-0.639	None	None	-0.634	None	None	None	None	None	None	None	0.013	None	None	0.09	0.341	None	None	None	9.12083E-04	1.73449E-04	4.83704E-04	0	0	None	1.09358E-04	1.65344E-04	9.12083E-04	1.1746E-03	1.09868E-05	5.60592E-04	None	N	None
18237	72	L/R	rs201412693	0.6850	gnomAD-2.1.1	98	None	0.276	0.2232	23.8	N	0.001	0.52	0.067315	-0.108	0.0919	-0.9948	0.12881019215	0.615	0.979709	0.526	0.554235320232	0.007	0.371591389179	-3.46	0.129	0.32	0.043	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	N	None
18237	72	L/R	rs201412693	0.6850	gnomAD-4.0.0	98	None	0.276	0.2232	23.8	N	0.001	0.52	0.067315	-0.108	0.0919	-0.9948	0.12881019215	0.615	0.979709	0.526	0.554235320232	0.007	0.371591389179	-3.46	0.129	0.32	0.043	None	None	1.1638E-05	0	0	0	0	None	0	0	1.1638E-05	1.52988E-05	0	0	None	N	None
18238	73	E/Q	None	0.5409	gnomAD-4.0.0	99	None	0.2619	0.2314	25.5	N	None	0.36	0.011673	0.069	0.3456	-0.4369	0.44064648589	2.38	0.999985	0.607	0.411133732114	0.999	0.536626458168	-2.5	0.416	0.676	0.009	None	None	1.59345E-06	0	0	0	0	None	0	0	1.59345E-06	0	1.43402E-05	0	None	N	None
18240	75	V/I	rs375141729	0.1974	gnomAD-2.1.1	102	None	0.0856	0.0772	None	N	-0.304	None	None	-0.313	None	None	None	None	None	None	None	0.213	None	None	0.111	0.293	None	None	None	4.64E-05	4.13873E-04	0	0	0	None	0	None	4.64E-05	0	2.35E-05	0	None	N	None
18240	75	V/I	rs375141729	0.1974	gnomAD-3.1.2	102	None	0.0856	0.0772	None	N	-0.304	None	None	-0.313	None	None	None	None	None	None	None	0.213	None	None	0.111	0.293	None	None	None	1.84327E-04	5.3135E-04	1.3132E-04	0	0	None	0	9.49367E-03	1.84327E-04	1.47E-05	0	0	None	N	None
18240	75	V/I	rs375141729	0.1974	gnomAD-4.0.0	102	None	0.0856	0.0772	None	N	-0.304	None	None	-0.313	None	None	None	None	None	None	None	0.213	None	None	0.111	0.293	None	None	None	5.20872E-05	6.00528E-04	5.00417E-05	0	0	None	0	4.96032E-04	5.20872E-05	1.86584E-05	1.0988E-05	1.60195E-04	None	N	None
18243	78	Q/E	rs372447571	0.1571	gnomAD-2.1.1	105	None	0.1314	0.1253	None	N	-2.041	None	None	-1.9	None	None	None	None	None	None	None	0.122	None	None	0.225	0.313	None	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	N	None
18243	78	Q/E	rs372447571	0.1571	gnomAD-4.0.0	105	None	0.1314	0.1253	None	N	-2.041	None	None	-1.9	None	None	None	None	None	None	None	0.122	None	None	0.225	0.313	None	None	None	2.05395E-06	0	0	0	0	None	0	0	2.05395E-06	2.69994E-06	0	0	None	N	None
18243	78	Q/H	rs548723690	0.1571	gnomAD-2.1.1	105	None	0.5954	0.4519	23.6	N	-2.017	0.37	0.016319	-1.49	0.2497	-0.5832	0.428440518575	2.185	0.995817	0.503	0.28492961333	0.998	0.536405444145	-3.5	0.323	0.679	0.04	None	None	8.05E-06	0	0	0	1.11757E-04	None	0	None	8.05E-06	0	0	0	None	N	None
18243	78	Q/H	rs548723690	0.1571	gnomAD-3.1.2	105	None	0.5954	0.4519	23.6	N	-2.017	0.37	0.016319	-1.49	0.2497	-0.5832	0.428440518575	2.185	0.995817	0.503	0.28492961333	0.998	0.536405444145	-3.5	0.323	0.679	0.04	None	None	1.32E-05	0	0	0	3.90168E-04	None	0	0	1.32E-05	0	0	0	None	N	None
18243	78	Q/H	rs548723690	0.1571	1000 genomes	105	None	0.5954	0.4519	23.6	N	-2.017	0.37	0.016319	-1.49	0.2497	-0.5832	0.428440518575	2.185	0.995817	0.503	0.28492961333	0.998	0.536405444145	-3.5	0.323	0.679	0.04	None	None	1.99681E-04	0	0	None	1E-03	0	None	None	1.99681E-04	None	0	None	None	N	None
18243	78	Q/H	rs548723690	0.1571	gnomAD-4.0.0	105	None	0.5954	0.4519	23.6	N	-2.017	0.37	0.016319	-1.49	0.2497	-0.5832	0.428440518575	2.185	0.995817	0.503	0.28492961333	0.998	0.536405444145	-3.5	0.323	0.679	0.04	None	None	2.4804E-06	0	0	0	8.93935E-05	None	0	0	2.4804E-06	0	0	0	None	N	None
18244	79	F/L	rs1301615048	0.1230	gnomAD-2.1.1	106	None	0.9972	0.9946	26.1	N	-1.129	0.23	0.028277	-1.375	0.2862	-0.5619	0.373637794796	2.765	0.999202	0.537	0.437741185291	0.989	0.72235673666	-4.8	0.483	0.691	0.005	None	None	1.07E-05	0	0	0	0	None	0	None	1.07E-05	0	2.35E-05	0	None	N	None
18244	79	F/L	rs1301615048	0.1230	gnomAD-3.1.2	106	None	0.9972	0.9946	26.1	N	-1.129	0.23	0.028277	-1.375	0.2862	-0.5619	0.373637794796	2.765	0.999202	0.537	0.437741185291	0.989	0.72235673666	-4.8	0.483	0.691	0.005	None	None	1.97E-05	0	0	0	0	None	0	0	1.97E-05	4.42E-05	0	0	None	N	None
18244	79	F/L	rs1301615048	0.1230	gnomAD-4.0.0	106	None	0.9972	0.9946	26.1	N	-1.129	0.23	0.028277	-1.375	0.2862	-0.5619	0.373637794796	2.765	0.999202	0.537	0.437741185291	0.989	0.72235673666	-4.8	0.483	0.691	0.005	None	None	6.41513E-06	0	0	0	0	None	0	0	6.41513E-06	1.19856E-05	0	0	None	N	None
18245	80	R/G	rs2054149835	0.1739	gnomAD-3.1.2	107	None	0.9842	0.972	30.0	D	None	0.16	0.05762	-2.166	0.5225	0.2128	0.523221014711	4.73	0.999958	0.761	0.707534925383	1.0	0.53250682354	-5.6	0.625	0.772	None	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18245	80	R/G	rs2054149835	0.1739	gnomAD-4.0.0	107	None	0.9842	0.972	30.0	D	None	0.16	0.05762	-2.166	0.5225	0.2128	0.523221014711	4.73	0.999958	0.761	0.707534925383	1.0	0.53250682354	-5.6	0.625	0.772	None	None	None	6.58085E-06	2.41464E-05	0	0	0	None	0	0	6.58085E-06	0	0	0	None	N	None
18245	80	R/K	None	0.1739	gnomAD-4.0.0	107	None	0.5647	0.5298	25.3	N	None	0.27	0.009029	-1.173	0.4229	-0.2263	0.462811898634	2.835	0.999997	0.706	0.406531046227	0.997	0.58717995882	-2.37	0.467	0.69	None	None	None	2.05397E-06	0	0	0	0	None	0	0	2.05397E-06	1.79998E-06	1.16036E-05	0	None	N	None
18245	80	R/T	None	0.1739	gnomAD-4.0.0	107	None	0.9768	0.9557	25.3	N	None	0.26	0.008893	-1.654	0.4467	-0.1486	0.559873948921	3.06	1.0	0.751	0.772450023565	1.0	0.57867193222	-4.73	0.52	0.777	None	None	None	1.36931E-06	0	0	0	2.52372E-05	None	0	0	1.36931E-06	8.99991E-07	0	0	None	N	None
18247	82	M/I	rs368858337	0.1454	gnomAD-2.1.1	109	None	0.7118	0.6714	24.3	N	-0.661	0.5	0.022369	-1.625	0.1125	-0.9883	0.105862237292	-0.08	0.999766	0.449	0.359963025489	0.042	0.472048819065	-2.57	0.197	0.668	0.368	None	None	1.21E-05	6.47E-05	0	0	0	None	0	None	1.21E-05	0	1.78E-05	0	None	N	None
18247	82	M/I	rs368858337	0.1454	gnomAD-3.1.2	109	None	0.7118	0.6714	24.3	N	-0.661	0.5	0.022369	-1.625	0.1125	-0.9883	0.105862237292	-0.08	0.999766	0.449	0.359963025489	0.042	0.472048819065	-2.57	0.197	0.668	0.368	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18247	82	M/I	rs368858337	0.1454	gnomAD-4.0.0	109	None	0.7118	0.6714	24.3	N	-0.661	0.5	0.022369	-1.625	0.1125	-0.9883	0.105862237292	-0.08	0.999766	0.449	0.359963025489	0.042	0.472048819065	-2.57	0.197	0.668	0.368	None	None	1.61261E-05	1.73555E-04	0	0	0	None	0	4.96196E-04	1.61261E-05	3.39314E-06	1.09941E-05	8.01179E-05	None	N	None
18247	82	M/T	rs200585270	0.1454	gnomAD-2.1.1	109	None	0.3449	0.3088	None	N	-1.839	None	None	-2.456	None	None	None	None	None	None	None	0.042	None	None	0.259	0.659	None	None	None	2.93098E-04	8.28E-05	1.24568E-03	7.75044E-04	0	None	0	None	2.93098E-04	0	1.25113E-04	1.68681E-03	None	N	None
18247	82	M/T	rs200585270	0.1454	gnomAD-3.1.2	109	None	0.3449	0.3088	None	N	-1.839	None	None	-2.456	None	None	None	None	None	None	None	0.042	None	None	0.259	0.659	None	None	None	1.51348E-04	7.24E-05	5.90319E-04	5.76369E-04	0	None	0	0	1.51348E-04	1.03056E-04	0	9.56023E-04	None	N	None
18247	82	M/T	rs200585270	0.1454	gnomAD-4.0.0	109	None	0.3449	0.3088	None	N	-1.839	None	None	-2.456	None	None	None	None	None	None	None	0.042	None	None	0.259	0.659	None	None	None	1.27761E-04	6.67236E-05	9.67344E-04	8.79686E-04	0	None	0	1.32319E-03	1.27761E-04	7.0407E-05	0	4.1656E-04	None	N	None
18251	86	A/T	None	0.6502	gnomAD-4.0.0	113	None	0.1021	0.0963	24.6	N	None	0.43	0.006559	-0.52	0.1594	-0.7774	0.180568113709	1.9	0.965509	0.402	0.250579442822	0.669	0.478187382221	-2.63	0.183	0.249	0.146	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
18252	87	A/V	rs551602191	0.4694	gnomAD-2.1.1	114	None	0.2933	0.3965	29.4	N	-0.185	0.41	0.006912	-0.348	0.2541	-0.601	0.462690307121	1.75	1.0	0.451	0.462461958149	1.0	0.652561545372	-3.07	0.376	0.731	0.088	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	I	None
18252	87	A/V	rs551602191	0.4694	gnomAD-3.1.2	114	None	0.2933	0.3965	29.4	N	-0.185	0.41	0.006912	-0.348	0.2541	-0.601	0.462690307121	1.75	1.0	0.451	0.462461958149	1.0	0.652561545372	-3.07	0.376	0.731	0.088	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	I	None
18252	87	A/V	rs551602191	0.4694	gnomAD-4.0.0	114	None	0.2933	0.3965	29.4	N	-0.185	0.41	0.006912	-0.348	0.2541	-0.601	0.462690307121	1.75	1.0	0.451	0.462461958149	1.0	0.652561545372	-3.07	0.376	0.731	0.088	None	None	1.2837E-05	0	0	0	0	None	0	0	1.2837E-05	2.15885E-05	0	2.85063E-05	None	I	None
18253	88	G/A	None	0.2010	gnomAD-4.0.0	115	None	0.923	0.8762	25.8	D	None	-0.34	0.046346	-0.545	0.6309	0.5425	0.369804762923	3.96	1.0	0.849	0.513167974481	0.984	0.731916904449	-4.67	0.646	0.683	None	None	None	1.59524E-06	0	0	0	0	None	0	0	1.59524E-06	2.86659E-06	0	0	None	I	None
18253	88	G/R	None	0.2010	gnomAD-4.0.0	115	None	0.9778	0.9631	23.5	D	None	-0.35	0.166102	-0.66	0.5146	0.2477	0.193022807787	4.855	1.0	0.871	0.692283160571	0.513	0.791753053665	-6.4	0.7	0.659	None	None	None	1.5949E-06	0	0	0	0	None	0	0	1.5949E-06	2.86587E-06	0	0	None	I	None
18254	89	I/F	rs766737617	0.4497	gnomAD-2.1.1	117	None	0.2486	0.2518	22.5	N	-1.539	0.61	0.047344	-1.019	0.1344	-0.9363	0.263660577288	1.195	0.99975	0.273	0.336400405673	0.638	0.357276201248	-2.87	0.07	0.774	0.01	None	None	1.21E-05	0	0	0	0	None	0	None	1.21E-05	0	2.67E-05	0	None	I	None
18254	89	I/F	rs766737617	0.4497	gnomAD-3.1.2	117	None	0.2486	0.2518	22.5	N	-1.539	0.61	0.047344	-1.019	0.1344	-0.9363	0.263660577288	1.195	0.99975	0.273	0.336400405673	0.638	0.357276201248	-2.87	0.07	0.774	0.01	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	I	None
18254	89	I/F	rs766737617	0.4497	gnomAD-4.0.0	117	None	0.2486	0.2518	22.5	N	-1.539	0.61	0.047344	-1.019	0.1344	-0.9363	0.263660577288	1.195	0.99975	0.273	0.336400405673	0.638	0.357276201248	-2.87	0.07	0.774	0.01	None	None	1.36479E-05	0	0	0	0	None	0	0	1.36479E-05	1.78161E-05	1.09953E-05	0	None	I	None
18254	89	I/T	rs1356331923	0.4497	gnomAD-2.1.1	117	None	0.1284	0.1209	24.3	N	-1.892	0.63	0.070011	-1.34	0.1321	-0.8943	0.164848116056	0.31	0.999869	0.315	0.432604763906	0.201	0.431959033012	-3.2	0.134	0.718	0.009	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	I	None
18254	89	I/T	rs1356331923	0.4497	gnomAD-4.0.0	117	None	0.1284	0.1209	24.3	N	-1.892	0.63	0.070011	-1.34	0.1321	-0.8943	0.164848116056	0.31	0.999869	0.315	0.432604763906	0.201	0.431959033012	-3.2	0.134	0.718	0.009	None	None	3.42479E-06	0	0	0	0	None	0	0	3.42479E-06	3.60125E-06	0	1.65893E-05	None	I	None
18255	90	G/A	None	0.2115	gnomAD-4.0.0	118	None	0.8624	0.8443	25.9	D	None	-0.01	0.029787	-0.824	0.5563	0.3396	0.369804762923	4.16	1.0	0.794	0.442567846599	0.969	0.683594107628	-4.73	0.585	0.699	0.021	None	None	6.85044E-07	0	0	0	0	None	0	0	6.85044E-07	9.00398E-07	0	0	None	N	None
18255	90	G/S	rs762872466	0.2115	gnomAD-2.1.1	118	None	0.5984	0.5516	26.6	N	-1.332	0.24	0.017242	-1.493	0.2741	-0.4903	0.422332236549	1.1	0.999997	0.714	0.321108458156	0.996	0.684460818768	-4.73	0.457	0.842	0.203	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	N	None
18255	90	G/S	rs762872466	0.2115	gnomAD-4.0.0	118	None	0.5984	0.5516	26.6	N	-1.332	0.24	0.017242	-1.493	0.2741	-0.4903	0.422332236549	1.1	0.999997	0.714	0.321108458156	0.996	0.684460818768	-4.73	0.457	0.842	0.203	None	None	1.59559E-06	0	0	0	0	None	0	0	1.59559E-06	2.86733E-06	0	0	None	N	None
18257	92	P/L	rs1429008245	0.4096	gnomAD-4.0.0	120	None	0.3828	0.2638	33.0	N	None	0.52	0.022237	-0.87	0.4262	-0.1218	0.417115216598	3.105	1.0	0.502	0.406806705197	0.998	0.638643801212	-7.6	0.363	0.753	0.045	None	None	1.59652E-06	0	0	0	0	None	0	0	1.59652E-06	0	0	3.03435E-05	None	I	None
18258	93	S/N	None	0.1268	gnomAD-4.0.0	121	None	0.9673	0.9665	26.4	D	None	-0.54	0.021387	-1.283	0.702	0.6041	0.448649923726	4.295	0.999999	0.582	0.503498835695	0.999	0.632222294807	-2.43	0.57	0.889	0.017	None	None	6.85289E-07	0	0	0	0	None	0	0	6.85289E-07	9.00726E-07	0	0	None	N	None
18258	93	S/T	rs770198717	0.1268	gnomAD-2.1.1	121	None	0.6244	0.5722	26.2	N	-0.981	-0.44	0.0214	-0.998	0.5478	0.0971	0.444156248343	3.285	0.999998	0.603	0.440915056915	0.999	0.587435722351	-2.4	0.538	0.885	0.041	None	None	4.03E-06	0	0	0	5.62E-05	None	0	None	4.03E-06	0	0	0	None	N	None
18259	94	E/K	None	0.5904	gnomAD-4.0.0	122	None	0.1617	0.1426	27.8	N	None	0.46	0.033571	0.234	0.1906	-0.7664	0.20816477634	1.095	0.999869	0.391	0.278143212241	0.919	0.724876403809	-3.03	0.198	0.561	0.027	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
18260	95	P/T	None	0.3330	gnomAD-4.0.0	123	None	0.1554	0.1303	27.5	N	None	0.53	0.029458	-1.516	0.2641	-0.6076	0.354588915174	2.21	0.994275	0.28	0.355242300401	0.986	0.588026225567	-4.43	0.271	0.643	0.567	None	None	1.59858E-06	0	0	0	0	None	0	0	1.59858E-06	2.87467E-06	0	0	None	N	None
18261	96	S/P	None	0.1119	gnomAD-4.0.0	124	None	0.9918	0.9877	27.2	N	None	0.52	0.029611	-0.032	0.4658	0.2073	0.406304590416	3.51	0.99954	0.252	0.395289904662	0.999	0.618213534355	-3.7	0.295	0.764	0.008	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	0	3.66327E-05	None	N	None
18262	97	D/G	None	0.6956	gnomAD-4.0.0	125	None	0.2527	0.2031	31.0	N	None	0.62	0.045792	-0.408	0.2092	-0.7235	0.413775783963	2.105	0.999995	0.255	0.326881540566	0.991	0.587599754333	-4.9	0.326	0.78	0.123	None	None	1.6019E-06	0	0	0	2.78676E-05	None	0	0	1.6019E-06	0	0	0	None	N	None
18263	98	P/A	None	0.3548	gnomAD-4.0.0	126	None	0.0705	0.0605	23.9	N	None	0.69	0.041757	-0.924	0.1728	-0.8588	0.0939716829773	1.275	0.968991	0.263	0.203808441222	0.104	0.424280375242	-4.73	0.256	0.393	0.565	None	None	1.60278E-06	0	0	0	0	None	0	0	1.60278E-06	2.88509E-06	0	0	None	N	None
18263	98	P/L	None	0.3548	gnomAD-4.0.0	126	None	0.1218	0.0831	25.1	N	None	0.7	0.015453	-0.586	0.1455	-0.9063	0.0856388048383	1.51	0.999841	0.301	0.358134431457	0.002	0.482839673758	-6.27	0.142	0.471	0.506	None	None	6.86437E-07	0	0	0	0	None	0	0	6.86437E-07	9.0221E-07	0	0	None	N	None
18264	99	E/A	None	0.3414	gnomAD-4.0.0	127	None	0.0595	0.0594	22.3	N	None	0.64	0.019816	-0.531	0.0974	-0.9889	0.0885378025442	-1.795	1.0	0.278	0.104622674875	None	0.391431629658	0.84	0.095	0.118	0.836	None	None	1.60669E-06	0	0	0	0	None	0	0	1.60669E-06	0	1.44329E-05	0	None	N	None
18264	99	E/K	rs1253287416	0.3414	gnomAD-2.1.1	127	None	0.272	0.1952	22.6	N	-0.696	0.65	0.006162	-0.693	0.0886	-1.0488	0.0944270478837	None	1.0	0.385	0.186928172975	0.001	0.459443390369	-0.58	0.079	0.398	0.488	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.93E-06	0	None	N	None
18264	99	E/K	rs1253287416	0.3414	gnomAD-4.0.0	127	None	0.272	0.1952	22.6	N	-0.696	0.65	0.006162	-0.693	0.0886	-1.0488	0.0944270478837	None	1.0	0.385	0.186928172975	0.001	0.459443390369	-0.58	0.079	0.398	0.488	None	None	4.12128E-06	0	0	0	0	None	0	0	4.12128E-06	5.41686E-06	0	0	None	N	None
18264	99	E/Q	rs1253287416	0.3414	gnomAD-4.0.0	127	None	0.1597	0.1306	22.2	N	None	0.67	0.004695	-1.015	0.0892	-1.0454	0.083793042556	-0.675	1.0	0.241	0.17258766438	0.007	0.387740701437	-0.57	0.067	0.346	0.419	None	None	2.74752E-06	0	0	0	2.53344E-05	None	0	0	2.74752E-06	9.02811E-07	1.16566E-05	1.6645E-05	None	N	None
18265	100	V/A	rs2054138018	0.3837	gnomAD-3.1.2	129	None	0.1486	0.1041	22.8	N	None	0.56	0.009983	-1.114	0.1022	-1.0282	0.102023578772	1.045	0.999999	0.317	0.368743488249	0.002	0.356508672237	-2.23	0.066	0.173	0.111	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
18265	100	V/A	rs2054138018	0.3837	gnomAD-4.0.0	129	None	0.1486	0.1041	22.8	N	None	0.56	0.009983	-1.114	0.1022	-1.0282	0.102023578772	1.045	0.999999	0.317	0.368743488249	0.002	0.356508672237	-2.23	0.066	0.173	0.111	None	None	3.91767E-06	1.70126E-05	0	0	0	None	0	0	3.91767E-06	4.91328E-06	0	0	None	N	None
18265	100	V/I	rs397517621	0.3837	gnomAD-4.0.0	129	None	0.0686	0.064	15.75	N	None	0.6	0.002001	-0.602	0.0591	-0.9779	0.0684251949703	0.89	1.0	0.264	0.104622674875	None	0.287869811058	-0.47	0.048	0.087	0.497	None	None	1.61921E-06	0	0	0	0	None	0	0	1.61921E-06	2.92423E-06	0	0	None	N	None
18266	101	A/S	rs199837769	0.1117	gnomAD-2.1.1	130	None	0.3271	0.3038	None	N	-2.147	None	None	-1.987	None	None	None	None	None	None	None	0.999	None	None	0.353	0.598	None	None	None	1.15539E-04	0	0	0	0	None	0	None	1.15539E-04	0	2.52235E-04	0	None	N	None
18266	101	A/S	rs199837769	0.1117	gnomAD-3.1.2	130	None	0.3271	0.3038	None	N	-2.147	None	None	-1.987	None	None	None	None	None	None	None	0.999	None	None	0.353	0.598	None	None	None	1.1844E-04	0	1.31199E-04	0	0	None	0	0	1.1844E-04	2.35509E-04	0	0	None	N	None
18266	101	A/S	rs199837769	0.1117	gnomAD-4.0.0	130	None	0.3271	0.3038	None	N	-2.147	None	None	-1.987	None	None	None	None	None	None	None	0.999	None	None	0.353	0.598	None	None	None	1.40839E-04	0	3.35762E-05	0	0	None	0	0	1.40839E-04	1.86611E-04	0	8.10504E-05	None	N	None
18266	101	A/T	None	0.1117	gnomAD-4.0.0	130	None	0.542	0.4461	26.8	N	None	0.53	0.008447	-1.781	0.314	-0.5219	0.456114532304	1.755	0.999998	0.313	0.340510301474	1.0	0.596991419792	-2.93	0.271	0.753	0.018	None	None	1.38351E-06	0	0	0	0	None	0	0	1.38351E-06	1.81774E-06	0	0	None	N	None
18267	102	G/E	rs878876923	0.2180	gnomAD-3.1.2	131	None	0.1467	0.0979	23.9	N	None	0.26	0.010852	-2.013	0.1179	-0.9543	0.112562523064	-0.05	0.757161	0.295	0.275641507738	0.013	0.413962066174	-3.6	0.166	0.541	1.0	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18267	102	G/E	rs878876923	0.2180	gnomAD-4.0.0	131	None	0.1467	0.0979	23.9	N	None	0.26	0.010852	-2.013	0.1179	-0.9543	0.112562523064	-0.05	0.757161	0.295	0.275641507738	0.013	0.413962066174	-3.6	0.166	0.541	1.0	None	None	2.61866E-06	0	0	0	0	None	0	0	2.61866E-06	4.92858E-06	0	0	None	N	None
18268	103	D/H	rs776957882	0.6505	gnomAD-2.1.1	132	None	0.8021	0.7267	26.2	N	0.601	0.96	0.011547	-0.039	0.2794	-0.6059	0.502564449384	3.545	1.0	0.237	0.277730125212	1.0	0.605299115181	-5.43	0.327	0.863	0.004	None	None	4.11E-06	0	0	0	0	None	3.36E-05	None	4.11E-06	0	0	0	None	N	None
18268	103	D/H	rs776957882	0.6505	gnomAD-4.0.0	132	None	0.8021	0.7267	26.2	N	0.601	0.96	0.011547	-0.039	0.2794	-0.6059	0.502564449384	3.545	1.0	0.237	0.277730125212	1.0	0.605299115181	-5.43	0.327	0.863	0.004	None	None	1.67442E-06	0	0	0	0	None	0	0	1.67442E-06	0	1.52486E-05	0	None	N	None
18268	103	D/N	None	0.6505	gnomAD-3.1.2	132	None	0.3147	0.2489	26.3	N	None	0.99	0.010232	0.111	0.2097	-0.7744	0.457538867752	2.445	1.0	0.214	0.206339911435	1.0	0.585819959641	-3.9	0.278	0.757	0.077	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
18268	103	D/N	None	0.6505	gnomAD-4.0.0	132	None	0.3147	0.2489	26.3	N	None	0.99	0.010232	0.111	0.2097	-0.7744	0.457538867752	2.445	1.0	0.214	0.206339911435	1.0	0.585819959641	-3.9	0.278	0.757	0.077	None	None	2.66966E-06	0	0	0	0	None	0	0	2.66966E-06	2.52297E-06	1.42017E-05	0	None	N	None
18268	103	D/Y	rs776957882	0.6505	gnomAD-4.0.0	132	None	0.6025	0.5625	26.3	N	None	0.98	0.010441	-0.064	0.3056	-0.5064	0.512659092959	3.89	1.0	0.315	0.567643136482	1.0	0.587037801743	-7.03	0.373	0.827	0.043	None	None	1.67442E-06	0	0	0	2.8335E-05	None	0	0	1.67442E-06	0	0	0	None	N	None

Whole Population MAF	African (AFR)	Latin American (AMR)
Amish (AMS)	Ashkenazi Jewish (ASJ)	East Asian (EAS)
European/1KGP (EUR)	Finnish (FIN)	Middle Eastern (MDE)
Non-Finnish European (NFE)	South Asian (SAS)	Other (OTH)

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