TITINdb

Map SAVs to Structure

Position	Domain position	SAV	Structural Position	RS	Q(SASA)	Disease	Source	MAF
23435	1	T/K	1	None	0.1667	None	gnomAD-4.0.0	2.05297E-06
23435	1	T/M	1	rs1324845938	0.1667	None	gnomAD-4.0.0	8.89624E-06
23436	2	P/S	2	None	0.1012	None	gnomAD-4.0.0	1.20032E-06
23437	3	G/D	3	rs1250159193	0.1918	None	gnomAD-2.1.1	4.02E-06
23437	3	G/D	3	rs1250159193	0.1918	None	gnomAD-4.0.0	1.59207E-06
23437	3	G/S	3	rs1448001247	0.1918	None	gnomAD-2.1.1	4.02E-06
23437	3	G/S	3	rs1448001247	0.1918	None	gnomAD-4.0.0	1.59196E-06
23438	4	P/L	4	None	0.3897	None	gnomAD-4.0.0	1.20032E-06
23439	5	V/A	5	None	0.1244	None	gnomAD-4.0.0	6.8441E-07
23441	7	N/K	7	rs751179969	0.6000	None	gnomAD-2.1.1	4.02E-06
23441	7	N/K	7	rs751179969	0.6000	None	gnomAD-4.0.0	6.84472E-07
23442	8	L/M	9	rs1553614105	0.2268	None	gnomAD-4.0.0	1.36897E-06
23443	9	R/G	11	rs765987438	0.3555	None	gnomAD-2.1.1	7.15E-06
23443	9	R/G	11	rs765987438	0.3555	None	gnomAD-3.1.2	6.58E-06
23443	9	R/G	11	rs765987438	0.3555	None	gnomAD-4.0.0	2.48005E-06
23443	9	R/Q	11	rs762529671	0.3555	None	gnomAD-2.1.1	3.22E-05
23443	9	R/Q	11	rs762529671	0.3555	None	gnomAD-3.1.2	2.63E-05
23443	9	R/Q	11	rs762529671	0.3555	None	gnomAD-4.0.0	3.22414E-05
23443	9	R/W	11	rs765987438	0.3555	None	gnomAD-2.1.1	7.15E-06
23443	9	R/W	11	rs765987438	0.3555	None	gnomAD-3.1.2	6.58E-06
23443	9	R/W	11	rs765987438	0.3555	None	gnomAD-4.0.0	3.10006E-06
23444	10	P/R	12	rs1325284144	0.4207	None	gnomAD-3.1.2	6.58E-06
23444	10	P/R	12	rs1325284144	0.4207	None	gnomAD-4.0.0	5.12919E-06
23445	11	T/A	13	rs1216746795	0.2731	None	gnomAD-4.0.0	6.00161E-06
23445	11	T/I	13	rs750009240	0.2731	None	gnomAD-2.1.1	1.61E-05
23445	11	T/I	13	rs750009240	0.2731	None	gnomAD-4.0.0	6.37119E-06
23446	12	D/A	14	None	0.5500	None	gnomAD-4.0.0	1.20032E-06
23446	12	D/N	14	rs1290459779	0.5500	None	gnomAD-2.1.1	4.02E-06
23446	12	D/N	14	rs1290459779	0.5500	None	gnomAD-4.0.0	1.59285E-06
23447	13	I/M	15	rs1213801020	0.3940	None	gnomAD-2.1.1	4.02E-06
23447	13	I/M	15	rs1213801020	0.3940	None	gnomAD-4.0.0	4.10714E-06
23447	13	I/V	15	None	0.3940	None	gnomAD-4.0.0	1.20032E-06
23448	14	T/A	16	None	0.2856	None	gnomAD-4.0.0	1.59277E-06
23448	14	T/R	16	None	0.2856	None	gnomAD-4.0.0	1.59278E-06
23449	15	K/N	17	rs957102264	0.4113	None	gnomAD-4.0.0	1.20032E-06
23451	17	S/R	19	rs754456949	0.1320	None	gnomAD-3.1.2	6.58E-06
23451	17	S/R	19	rs754456949	0.1320	None	gnomAD-4.0.0	6.57834E-06
23451	17	S/T	19	rs1339742394	0.1320	None	gnomAD-2.1.1	4.02E-06
23451	17	S/T	19	rs1339742394	0.1320	None	gnomAD-4.0.0	3.18474E-06
23452	18	V/I	20	None	0.1133	None	gnomAD-4.0.0	1.20032E-06
23453	19	T/I	21	rs1435352674	0.1450	None	gnomAD-2.1.1	4.02E-06
23453	19	T/I	21	rs1435352674	0.1450	None	gnomAD-4.0.0	1.59201E-06
23453	19	T/N	21	None	0.1450	None	gnomAD-4.0.0	3.18402E-06
23457	23	D/N	25	None	0.3947	None	gnomAD-4.0.0	1.20032E-06
23457	23	D/V	25	rs535816123	0.3947	None	gnomAD-2.1.1	2.82E-05
23457	23	D/V	25	rs535816123	0.3947	None	gnomAD-3.1.2	1.32E-05
23457	23	D/V	25	rs535816123	0.3947	None	1000 genomes	1.99681E-04
23457	23	D/V	25	rs535816123	0.3947	None	gnomAD-4.0.0	1.53793E-05
23458	24	L/F	26	rs1709865828	0.7789	None	gnomAD-4.0.0	1.5919E-06
23459	25	P/L	27	rs776457502	0.1974	None	gnomAD-2.1.1	4.02E-06
23459	25	P/L	27	rs776457502	0.1974	None	gnomAD-4.0.0	4.79033E-06
23460	26	L/R	28	rs879027466	1.0320	None	gnomAD-3.1.2	1.97E-05
23460	26	L/R	28	rs879027466	1.0320	None	gnomAD-4.0.0	5.12638E-06
23461	27	I/M	29	None	0.3126	None	gnomAD-4.0.0	1.59186E-06
23461	27	I/R	29	rs775762472	0.3126	None	gnomAD-2.1.1	4.02E-06
23461	27	I/R	29	rs775762472	0.3126	None	gnomAD-4.0.0	1.59189E-06
23461	27	I/V	29	rs1170300318	0.3126	None	gnomAD-2.1.1	4.02E-06
23461	27	I/V	29	rs1170300318	0.3126	None	gnomAD-4.0.0	3.18369E-06
23462	28	D/N	30	None	0.3595	None	gnomAD-4.0.0	1.36861E-06
23463	29	G/A	31	rs745946955	0.1088	None	gnomAD-2.1.1	4.02E-06
23463	29	G/A	31	rs745946955	0.1088	None	gnomAD-4.0.0	1.59179E-06
23464	30	G/A	32	None	0.2600	None	gnomAD-4.0.0	1.36861E-06
23464	30	G/D	32	rs549938348	0.2600	None	1000 genomes	1.99681E-04
23464	30	G/D	32	rs549938348	0.2600	None	gnomAD-4.0.0	6.84303E-07
23464	30	G/R	32	None	0.2600	None	gnomAD-4.0.0	1.20032E-06
23464	30	G/V	32	rs549938348	0.2600	None	gnomAD-2.1.1	4.02E-06
23464	30	G/V	32	rs549938348	0.2600	None	gnomAD-3.1.2	1.32E-05
23464	30	G/V	32	rs549938348	0.2600	None	gnomAD-4.0.0	6.81791E-06
23466	32	R/C	34	rs749744742	0.8526	None	gnomAD-2.1.1	1.07E-05
23466	32	R/C	34	rs749744742	0.8526	None	gnomAD-3.1.2	1.97E-05
23466	32	R/C	34	rs749744742	0.8526	None	gnomAD-4.0.0	8.67778E-06
23466	32	R/G	34	None	0.8526	None	gnomAD-4.0.0	6.84309E-07
23466	32	R/H	34	rs1193026411	0.8526	None	gnomAD-2.1.1	8.05E-06
23466	32	R/H	34	rs1193026411	0.8526	None	gnomAD-4.0.0	1.0949E-05
23466	32	R/P	34	None	0.8526	None	gnomAD-4.0.0	6.84315E-07
23466	32	R/S	34	rs749744742	0.8526	None	gnomAD-4.0.0	1.36862E-06
23467	33	I/M	35	None	0.2184	None	gnomAD-4.0.0	1.59181E-06
23467	33	I/T	35	rs778170654	0.2184	None	gnomAD-2.1.1	4.02E-06
23467	33	I/V	35	rs866974760	0.2184	None	gnomAD-4.0.0	2.05293E-06
23468	34	T/K	36	None	0.3562	None	gnomAD-4.0.0	1.59179E-06
23470	36	Y/C	38	rs750891099	0.1370	None	gnomAD-2.1.1	4.03E-06
23470	36	Y/C	38	rs750891099	0.1370	None	gnomAD-4.0.0	1.84762E-05
23470	36	Y/D	38	rs753051564	0.1370	None	gnomAD-2.1.1	4.03E-06
23470	36	Y/D	38	rs753051564	0.1370	None	gnomAD-4.0.0	1.59176E-06
23471	37	I/M	39	rs764793576	0.1933	None	gnomAD-2.1.1	4.03E-06
23471	37	I/T	39	rs1475765674	0.1933	None	gnomAD-3.1.2	6.58E-06
23471	37	I/T	39	rs1475765674	0.1933	None	gnomAD-4.0.0	4.33881E-06
23471	37	I/V	39	None	0.1933	None	gnomAD-4.0.0	1.20033E-06
23472	38	V/I	40	rs556399127	0.1028	None	gnomAD-2.1.1	4.03E-06
23472	38	V/I	40	rs556399127	0.1028	None	gnomAD-4.0.0	3.18349E-06
23473	39	E/Q	41	None	0.1182	None	gnomAD-4.0.0	1.59176E-06
23474	40	K/E	42	None	0.2456	None	gnomAD-4.0.0	1.59175E-06
23475	41	R/C	43	rs761442543	0.1122	None	gnomAD-2.1.1	2.5E-05
23475	41	R/C	43	rs761442543	0.1122	None	gnomAD-3.1.2	3.29E-05
23475	41	R/C	43	rs761442543	0.1122	None	gnomAD-4.0.0	2.66528E-05
23475	41	R/H	43	rs370257707	0.1122	None	gnomAD-2.1.1	3.22E-05
23475	41	R/H	43	rs370257707	0.1122	None	gnomAD-3.1.2	3.95E-05
23475	41	R/H	43	rs370257707	0.1122	None	gnomAD-4.0.0	7.37575E-05
23477	43	A/E	50	None	0.2369	None	gnomAD-4.0.0	1.20032E-06
23477	43	A/T	50	rs763988813	0.2369	None	gnomAD-2.1.1	2.01E-05
23477	43	A/T	50	rs763988813	0.2369	None	gnomAD-4.0.0	8.21163E-06
23479	45	R/Q	60	rs140127488	0.4740	None	gnomAD-2.1.1	1.21E-05
23479	45	R/Q	60	rs140127488	0.4740	None	gnomAD-3.1.2	6.58E-06
23479	45	R/Q	60	rs140127488	0.4740	None	1000 genomes	1.99681E-04
23479	45	R/Q	60	rs140127488	0.4740	None	gnomAD-4.0.0	1.54944E-05
23479	45	R/W	60	rs760509116	0.4740	None	gnomAD-2.1.1	6.08E-05
23479	45	R/W	60	rs760509116	0.4740	None	gnomAD-3.1.2	3.29E-05
23479	45	R/W	60	rs760509116	0.4740	None	gnomAD-4.0.0	3.09884E-05
23480	46	K/Q	63	None	1.0609	None	gnomAD-4.0.0	1.59177E-06
23482	48	Y/F	65	None	0.2103	None	gnomAD-4.0.0	2.40064E-06
23483	49	S/Y	66	None	0.3673	None	gnomAD-4.0.0	1.59171E-06
23484	50	T/K	67	rs1178437079	0.4412	None	gnomAD-2.1.1	4.02E-06
23484	50	T/K	67	rs1178437079	0.4412	None	gnomAD-4.0.0	6.84284E-07
23484	50	T/R	67	None	0.4412	None	gnomAD-4.0.0	6.84284E-07
23485	51	A/D	68	None	0.2199	None	gnomAD-4.0.0	2.40064E-06
23486	52	T/I	69	rs774575929	0.1473	None	gnomAD-2.1.1	8.05E-06
23486	52	T/I	69	rs774575929	0.1473	None	gnomAD-4.0.0	2.05284E-06
23487	53	T/I	70	None	0.5105	None	gnomAD-4.0.0	2.73715E-06
23487	53	T/S	70	None	0.5105	None	gnomAD-4.0.0	6.84287E-07
23488	54	K/E	75	None	0.8363	None	gnomAD-4.0.0	1.36858E-06
23488	54	K/R	75	None	0.8363	None	gnomAD-4.0.0	1.20032E-06
23489	55	C/F	77	None	0.1046	None	gnomAD-4.0.0	3.42146E-06
23489	55	C/S	77	rs1471554561	0.1046	None	gnomAD-2.1.1	4.02E-06
23490	56	H/D	83	rs1397554911	0.7122	None	gnomAD-3.1.2	6.58E-06
23490	56	H/D	83	rs1397554911	0.7122	None	gnomAD-4.0.0	3.84475E-06
23493	59	T/I	90	None	0.3158	None	gnomAD-4.0.0	6.00161E-06
23493	59	T/S	90	rs375675901	0.3158	None	gnomAD-3.1.2	2.63E-05
23493	59	T/S	90	rs375675901	0.3158	None	gnomAD-4.0.0	7.43708E-06
23494	60	Y/H	91	rs72646888	0.2637	None	gnomAD-4.0.0	6.84286E-06
23494	60	Y/N	91	None	0.2637	None	gnomAD-4.0.0	6.84286E-07
23495	61	K/E	92	None	0.3814	None	gnomAD-4.0.0	3.18337E-06
23495	61	K/N	92	rs1482776876	0.3814	None	gnomAD-2.1.1	2.01E-05
23495	61	K/N	92	rs1482776876	0.3814	None	gnomAD-4.0.0	1.437E-05
23496	62	V/L	93	None	0.1444	None	gnomAD-4.0.0	1.20032E-06
23497	63	T/I	94	None	0.5598	None	gnomAD-4.0.0	1.5917E-06
23498	64	G/D	96	rs770261949	0.4495	None	gnomAD-2.1.1	4.02E-06
23498	64	G/S	96	rs370771532	0.4495	None	gnomAD-2.1.1	2.32246E-04
23498	64	G/S	96	rs370771532	0.4495	None	gnomAD-3.1.2	2.43328E-04
23498	64	G/S	96	rs370771532	0.4495	None	gnomAD-4.0.0	1.80983E-04
23499	65	L/F	97	rs75626265	0.1422	None	gnomAD-4.0.0	6.37414E-05
23499	65	L/S	97	None	0.1422	None	gnomAD-4.0.0	1.20032E-06
23500	66	S/C	98	rs774745687	0.4656	None	gnomAD-4.0.0	3.1837E-06
23500	66	S/T	98	None	0.4656	None	gnomAD-4.0.0	1.20032E-06
23501	67	E/K	99	rs1709809170	0.6558	None	gnomAD-4.0.0	4.77544E-06
23502	68	G/A	100	rs755417099	0.3223	None	gnomAD-4.0.0	1.59176E-06
23502	68	G/E	100	rs755417099	0.3223	None	gnomAD-2.1.1	1.21E-05
23502	68	G/E	100	rs755417099	0.3223	None	gnomAD-4.0.0	4.77529E-06
23502	68	G/R	100	rs781343586	0.3223	None	gnomAD-2.1.1	8.05E-06
23502	68	G/R	100	rs781343586	0.3223	None	gnomAD-4.0.0	4.77529E-06
23503	69	C/G	102	rs778748283	0.2518	None	gnomAD-4.0.0	2.28268E-03
23503	69	C/Y	102	rs1466729716	0.2518	None	gnomAD-2.1.1	4.03E-06
23503	69	C/Y	102	rs1466729716	0.2518	None	gnomAD-4.0.0	1.59172E-06
23504	70	E/D	103	None	0.4529	None	gnomAD-4.0.0	6.84291E-07
23504	70	E/Q	103	rs1362847983	0.4529	None	gnomAD-2.1.1	3.19E-05
23504	70	E/Q	103	rs1362847983	0.4529	None	gnomAD-3.1.2	6.57E-06
23504	70	E/Q	103	rs1362847983	0.4529	None	gnomAD-4.0.0	5.07505E-06
23505	71	Y/D	104	None	0.1089	None	gnomAD-4.0.0	1.20032E-06
23506	72	F/L	105	rs753350142	0.1620	None	gnomAD-2.1.1	4.02E-06
23506	72	F/L	105	rs753350142	0.1620	None	gnomAD-4.0.0	1.59165E-06
23507	73	F/L	106	rs764286640	0.1332	None	gnomAD-2.1.1	4.02E-06
23507	73	F/L	106	rs764286640	0.1332	None	gnomAD-4.0.0	3.18322E-06
23508	74	R/G	107	rs1709797711	0.2078	None	gnomAD-3.1.2	6.57E-06
23508	74	R/G	107	rs1709797711	0.2078	None	gnomAD-4.0.0	6.57358E-06
23508	74	R/I	107	rs1414118885	0.2078	None	gnomAD-2.1.1	4.02E-06
23508	74	R/I	107	rs1414118885	0.2078	None	gnomAD-4.0.0	2.73711E-06
23509	75	V/E	108	rs926271333	0.0942	None	gnomAD-4.0.0	6.8427E-07
23509	75	V/G	108	rs926271333	0.0942	None	gnomAD-4.0.0	6.8427E-07
23510	76	M/I	109	rs727503569	0.1200	None	gnomAD-3.1.2	6.58E-06
23510	76	M/I	109	rs727503569	0.1200	None	gnomAD-4.0.0	3.71861E-06
23510	76	M/T	109	None	0.1200	None	gnomAD-4.0.0	1.20032E-06
23510	76	M/V	109	None	0.1200	None	gnomAD-4.0.0	1.36852E-06
23511	77	A/G	110	rs1709793052	0.1236	None	gnomAD-4.0.0	5.4741E-06
23511	77	A/T	110	rs1423033072	0.1236	None	gnomAD-2.1.1	4.02E-06
23511	77	A/T	110	rs1423033072	0.1236	None	gnomAD-4.0.0	1.59158E-06
23512	78	E/D	111	None	0.2663	None	gnomAD-4.0.0	1.20032E-06
23512	78	E/G	111	None	0.2663	None	gnomAD-4.0.0	1.59157E-06
23512	78	E/K	111	rs752696466	0.2663	None	gnomAD-2.1.1	4.02E-06
23512	78	E/K	111	rs752696466	0.2663	None	gnomAD-4.0.0	1.59154E-06
23513	79	N/S	112	rs1553613561	0.0945	None	gnomAD-4.0.0	2.05278E-06
23514	80	E/K	113	None	0.3997	None	gnomAD-4.0.0	6.84261E-07
23515	81	Y/C	114	None	0.3226	None	gnomAD-4.0.0	8.89535E-06
23515	81	Y/D	114	None	0.3226	None	gnomAD-4.0.0	1.59154E-06
23518	84	G/A	118	None	0.1507	None	gnomAD-4.0.0	1.59154E-06
23519	85	E/K	119	rs1267057579	0.3948	None	gnomAD-2.1.1	4.02E-06
23519	85	E/K	119	rs1267057579	0.3948	None	gnomAD-4.0.0	2.05277E-06
23520	86	P/L	120	rs763169614	0.4608	None	gnomAD-2.1.1	1.21E-05
23520	86	P/L	120	rs763169614	0.4608	None	gnomAD-4.0.0	1.98434E-05
23520	86	P/R	120	rs763169614	0.4608	None	gnomAD-2.1.1	3.19E-05
23520	86	P/R	120	rs763169614	0.4608	None	gnomAD-3.1.2	6.58E-06
23520	86	P/R	120	rs763169614	0.4608	None	gnomAD-4.0.0	6.57912E-06
23520	86	P/T	120	rs1296805014	0.4608	None	gnomAD-2.1.1	3.19E-05
23520	86	P/T	120	rs1296805014	0.4608	None	gnomAD-3.1.2	6.58E-06
23520	86	P/T	120	rs1296805014	0.4608	None	gnomAD-4.0.0	6.57756E-06
23521	87	T/I	121	rs775589244	0.2440	None	gnomAD-2.1.1	4.02E-06
23521	87	T/I	121	rs775589244	0.2440	None	gnomAD-4.0.0	6.84256E-07
23521	87	T/P	121	rs1007385866	0.2440	None	gnomAD-3.1.2	6.57E-06
23521	87	T/P	121	rs1007385866	0.2440	None	gnomAD-4.0.0	6.5735E-06
23521	87	T/R	121	rs775589244	0.2440	None	gnomAD-2.1.1	3.22E-05
23521	87	T/R	121	rs775589244	0.2440	None	gnomAD-3.1.2	1.32E-05
23521	87	T/R	121	rs775589244	0.2440	None	gnomAD-4.0.0	1.73537E-05
23522	88	E/K	122	rs561586925	0.2700	None	gnomAD-2.1.1	2.41E-05
23522	88	E/K	122	rs561586925	0.2700	None	gnomAD-3.1.2	1.97E-05
23522	88	E/K	122	rs561586925	0.2700	None	1000 genomes	1.99681E-04
23522	88	E/K	122	rs561586925	0.2700	None	gnomAD-4.0.0	7.43646E-06
23524	90	T/A	124	rs369526268	0.8534	None	gnomAD-2.1.1	2.82E-05
23524	90	T/A	124	rs369526268	0.8534	None	gnomAD-3.1.2	4.6E-05
23524	90	T/A	124	rs369526268	0.8534	None	gnomAD-4.0.0	5.57772E-05
23524	90	T/K	124	rs748544908	0.8534	None	gnomAD-2.1.1	4.02E-06
23524	90	T/K	124	rs748544908	0.8534	None	gnomAD-4.0.0	6.84257E-07
23524	90	T/R	124	None	0.8534	None	gnomAD-4.0.0	6.84257E-07
23525	91	E/G	125	rs1709774465	0.5547	None	gnomAD-4.0.0	1.59151E-06
23527	93	V/I	127	rs542004766	0.2273	None	gnomAD-2.1.1	4.64E-05
23527	93	V/I	127	rs542004766	0.2273	None	gnomAD-3.1.2	5.92E-05
23527	93	V/I	127	rs542004766	0.2273	None	1000 genomes	1.99681E-04
23527	93	V/I	127	rs542004766	0.2273	None	gnomAD-4.0.0	2.60283E-05
23527	93	V/L	127	rs542004766	0.2273	None	gnomAD-2.1.1	4.02E-06
23527	93	V/L	127	rs542004766	0.2273	None	gnomAD-3.1.2	6.58E-06
23527	93	V/L	127	rs542004766	0.2273	None	gnomAD-4.0.0	2.47907E-06
23528	94	K/N	129	None	0.4352	None	gnomAD-4.0.0	1.59151E-06
23529	95	A/V	130	rs1709769243	0.0951	None	gnomAD-4.0.0	2.73701E-06
23531	97	E/K	132	rs1182129747	0.6122	None	gnomAD-3.1.2	6.57E-06
23531	97	E/K	132	rs1182129747	0.6122	None	gnomAD-4.0.0	2.03004E-06

Position	Domain position	SAV	RS	Q(SASA)	Source	Structural Position	Disease	AlphaMissense (IC)	AlphaMissense (N2AB)	CADD	Condel	DUET	FATHMM	M-CAP	mCSM	MetaLR	MetaSVM	MPC	MutationAssessor	MutationTaster	MutPred	MVP	PolyPhen-2	PrimateAI	PROVEAN	REVEL	Rhapsody	SIFT	Zygosity	Comments	MAF	AFR	AMR	AMS	ASJ	EAS	EUR	FIN	MDE	NFE	SAS	OTH	Site Annotation	Predicted PPI	mCSM-PPI
23435	1	T/K	None	0.1667	gnomAD-4.0.0	1	None	0.618	0.7126	25.1	N	None	1.12	0.016601	-0.528	0.1256	-0.9226	0.158307195494	0.895	0.995289	0.472	0.277317399466	0.893	0.709629297256	-3.98	0.354	0.561	0.003	None	None	2.05297E-06	0	0	0	0	None	0	0	2.05297E-06	2.69883E-06	0	0	None	I	None
23435	1	T/M	rs1324845938	0.1667	gnomAD-4.0.0	1	None	0.2779	0.3442	24.8	N	None	0.99	0.047819	-0.063	0.1743	-0.5824	0.105795419672	3.07	0.991524	0.333	0.423836183345	0.793	0.684330701828	-4.07	0.414	0.521	0.001	None	None	8.89624E-06	2.98918E-05	2.23624E-05	0	2.52169E-05	None	0	0	8.89624E-06	7.19689E-06	1.15955E-05	1.65684E-05	None	I	None
23436	2	P/S	None	0.1012	gnomAD-4.0.0	2	None	0.9875	0.9895	27.5	D	None	-2.11	0.394764	-1.935	0.8976	1.0448	0.466031226403	2.965	1.0	0.881	0.779722169719	1.0	0.706433653831	-5.87	0.819	0.797	None	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23437	3	G/D	rs1250159193	0.1918	gnomAD-2.1.1	3	None	0.9637	0.9803	26.9	N	-1.818	0.56	0.018407	-1.939	0.3631	-0.3309	0.527275360279	2.135	1.0	0.509	0.247872288689	1.0	0.795776128769	-5.13	0.405	0.861	0.004	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
23437	3	G/D	rs1250159193	0.1918	gnomAD-4.0.0	3	None	0.9637	0.9803	26.9	N	-1.818	0.56	0.018407	-1.939	0.3631	-0.3309	0.527275360279	2.135	1.0	0.509	0.247872288689	1.0	0.795776128769	-5.13	0.405	0.861	0.004	None	None	1.59207E-06	0	0	0	0	None	0	0	1.59207E-06	0	1.43303E-05	0	None	N	None
23437	3	G/S	rs1448001247	0.1918	gnomAD-2.1.1	3	None	0.3832	0.4682	26.2	N	-1.138	0.7	0.017036	-1.332	0.3208	-0.4385	0.463496485926	2.005	1.0	0.444	0.225215365344	1.0	0.727875471115	-4.4	0.475	0.784	0.092	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	N	None
23437	3	G/S	rs1448001247	0.1918	gnomAD-4.0.0	3	None	0.3832	0.4682	26.2	N	-1.138	0.7	0.017036	-1.332	0.3208	-0.4385	0.463496485926	2.005	1.0	0.444	0.225215365344	1.0	0.727875471115	-4.4	0.475	0.784	0.092	None	None	1.59196E-06	0	0	0	0	None	0	0	1.59196E-06	2.85986E-06	0	0	None	N	None
23438	4	P/L	None	0.3897	gnomAD-4.0.0	4	None	0.3701	0.4332	34.0	N	None	0.24	0.017217	-0.767	0.5225	0.2187	0.469722267271	3.385	1.0	0.582	0.795181792715	1.0	0.69844943285	-7.0	0.486	0.89	0.003	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
23439	5	V/A	None	0.1244	gnomAD-4.0.0	5	None	0.426	0.4935	34.0	N	None	0.56	0.025195	-2.133	0.2513	-0.418	0.492324752557	0.88	0.524753	0.524	0.475506082792	0.963	0.594265341759	-1.93	0.272	0.683	0.635	None	None	6.8441E-07	0	0	0	0	None	0	0	6.8441E-07	8.99734E-07	0	0	None	N	None
23441	7	N/K	rs751179969	0.6000	gnomAD-2.1.1	7	None	0.3763	0.4809	23.8	N	0.266	0.12	0.031856	0.001	0.1752	-0.8266	0.107911842593	1.19	0.99868	0.649	0.126345400529	0.117	0.73413926363	-4.4	0.12	0.287	0.014	None	None	4.02E-06	6.46E-05	0	0	0	None	0	None	4.02E-06	0	0	0	None	I	None
23441	7	N/K	rs751179969	0.6000	gnomAD-4.0.0	7	None	0.3763	0.4809	23.8	N	0.266	0.12	0.031856	0.001	0.1752	-0.8266	0.107911842593	1.19	0.99868	0.649	0.126345400529	0.117	0.73413926363	-4.4	0.12	0.287	0.014	None	None	6.84472E-07	0	0	0	0	None	0	0	6.84472E-07	8.99824E-07	0	0	None	I	None
23442	8	L/M	rs1553614105	0.2268	gnomAD-4.0.0	9	None	0.2884	0.331	27.1	N	None	-0.14	0.013572	-0.967	0.4736	0.0725	0.244255991014	2.985	0.999872	0.615	0.568785453283	0.949	0.60054987669	-1.43	0.355	0.645	0.013	None	None	1.36897E-06	0	0	0	0	None	0	0	1.36897E-06	1.79969E-06	0	0	None	N	None
23443	9	R/G	rs765987438	0.3555	gnomAD-2.1.1	11	None	0.2862	0.3303	23.4	N	-1.283	0.33	0.043037	-1.05	0.1546	-0.7763	0.135268802136	1.785	0.597008	0.514	0.288352970974	0.251	0.428950309753	-4.12	0.148	0.519	0.087	None	None	7.15E-06	0	0	0	0	None	0	None	7.15E-06	0	1.56E-05	0	None	N	None
23443	9	R/G	rs765987438	0.3555	gnomAD-3.1.2	11	None	0.2862	0.3303	23.4	N	-1.283	0.33	0.043037	-1.05	0.1546	-0.7763	0.135268802136	1.785	0.597008	0.514	0.288352970974	0.251	0.428950309753	-4.12	0.148	0.519	0.087	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
23443	9	R/G	rs765987438	0.3555	gnomAD-4.0.0	11	None	0.2862	0.3303	23.4	N	-1.283	0.33	0.043037	-1.05	0.1546	-0.7763	0.135268802136	1.785	0.597008	0.514	0.288352970974	0.251	0.428950309753	-4.12	0.148	0.519	0.087	None	None	2.48005E-06	0	0	0	0	None	0	0	2.48005E-06	3.3922E-06	0	0	None	N	None
23443	9	R/Q	rs762529671	0.3555	gnomAD-2.1.1	11	None	0.0785	0.079	24.2	N	-0.131	0.43	0.012651	-0.304	0.0826	-0.9636	0.11901638431	0.17	0.730384	0.446	0.107399877778	0.271	0.384926855564	-2.07	0.047	0.414	0.039	None	None	3.22E-05	4.13E-05	0	0	0	None	6.54E-05	None	3.22E-05	0	3.91E-05	1.40568E-04	None	N	None
23443	9	R/Q	rs762529671	0.3555	gnomAD-3.1.2	11	None	0.0785	0.079	24.2	N	-0.131	0.43	0.012651	-0.304	0.0826	-0.9636	0.11901638431	0.17	0.730384	0.446	0.107399877778	0.271	0.384926855564	-2.07	0.047	0.414	0.039	None	None	2.63E-05	0	0	0	0	None	0	0	2.63E-05	5.88E-05	0	0	None	N	None
23443	9	R/Q	rs762529671	0.3555	gnomAD-4.0.0	11	None	0.0785	0.079	24.2	N	-0.131	0.43	0.012651	-0.304	0.0826	-0.9636	0.11901638431	0.17	0.730384	0.446	0.107399877778	0.271	0.384926855564	-2.07	0.047	0.414	0.039	None	None	3.22414E-05	4.00759E-05	0	0	0	None	7.81421E-05	0	3.22414E-05	3.30736E-05	4.3929E-05	1.60179E-05	None	N	None
23443	9	R/W	rs765987438	0.3555	gnomAD-2.1.1	11	None	0.1835	0.1838	26.7	N	-0.227	0.29	0.039279	0.054	0.344	-0.1156	0.366821001965	2.475	0.726809	0.525	0.277317399466	0.984	0.491813242435	-4.97	0.39	0.602	0.003	None	None	7.15E-06	0	0	9.68E-05	5.14E-05	None	0	None	7.15E-06	0	0	0	None	N	None
23443	9	R/W	rs765987438	0.3555	gnomAD-3.1.2	11	None	0.1835	0.1838	26.7	N	-0.227	0.29	0.039279	0.054	0.344	-0.1156	0.366821001965	2.475	0.726809	0.525	0.277317399466	0.984	0.491813242435	-4.97	0.39	0.602	0.003	None	None	6.58E-06	0	0	0	1.93874E-04	None	0	0	6.58E-06	0	0	0	None	N	None
23443	9	R/W	rs765987438	0.3555	gnomAD-4.0.0	11	None	0.1835	0.1838	26.7	N	-0.227	0.29	0.039279	0.054	0.344	-0.1156	0.366821001965	2.475	0.726809	0.525	0.277317399466	0.984	0.491813242435	-4.97	0.39	0.602	0.003	None	None	3.10006E-06	0	0	3.37952E-05	4.46468E-05	None	0	0	3.10006E-06	8.4805E-07	1.09813E-05	0	None	N	None
23444	10	P/R	rs1325284144	0.4207	gnomAD-3.1.2	12	None	0.7124	0.7596	34.0	N	None	0.45	0.020035	-1.104	0.3111	-0.4782	0.426506705413	1.935	0.999993	0.597	0.446813524615	0.997	0.704486846924	-5.9	0.398	0.869	0.042	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
23444	10	P/R	rs1325284144	0.4207	gnomAD-4.0.0	12	None	0.7124	0.7596	34.0	N	None	0.45	0.020035	-1.104	0.3111	-0.4782	0.426506705413	1.935	0.999993	0.597	0.446813524615	0.997	0.704486846924	-5.9	0.398	0.869	0.042	None	None	5.12919E-06	0	0	0	0	None	0	0	5.12919E-06	9.58414E-06	0	0	None	N	None
23445	11	T/A	rs1216746795	0.2731	gnomAD-4.0.0	13	None	0.0719	0.0754	23.2	N	None	0.3	0.049276	-0.79	0.1963	-0.6956	0.148614217713	1.595	0.999667	0.443	0.162503812791	0.625	0.461109638214	-2.75	0.17	0.335	0.15	None	None	6.00161E-06	0	0	0	0	None	0	0	6.00161E-06	6.56251E-06	0	0	None	N	None
23445	11	T/I	rs750009240	0.2731	gnomAD-2.1.1	13	None	0.1459	0.1508	28.8	D	0.065	0.32	0.017345	-0.068	0.2719	-0.5186	0.326578704726	1.25	0.999774	0.486	0.383921772103	0.966	0.575407505035	-3.43	0.265	0.437	0.11	None	None	1.61E-05	0	1.15935E-04	0	0	None	0	None	1.61E-05	0	0	0	None	N	None
23445	11	T/I	rs750009240	0.2731	gnomAD-4.0.0	13	None	0.1459	0.1508	28.8	D	0.065	0.32	0.017345	-0.068	0.2719	-0.5186	0.326578704726	1.25	0.999774	0.486	0.383921772103	0.966	0.575407505035	-3.43	0.265	0.437	0.11	None	None	6.37119E-06	0	9.14913E-05	0	0	None	0	0	6.37119E-06	0	0	0	None	N	None
23446	12	D/A	None	0.5500	gnomAD-4.0.0	14	None	0.1107	0.1465	29.3	N	None	0.42	0.031317	-0.343	0.1671	-0.8182	0.152993993906	1.845	0.99999	0.558	0.344945010812	0.338	0.456249296665	-4.17	0.311	0.464	0.191	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23446	12	D/N	rs1290459779	0.5500	gnomAD-2.1.1	14	None	0.0883	0.0992	23.7	N	0.399	0.44	0.037759	-0.068	0.1885	-0.7734	0.165591226774	1.705	0.999996	0.594	0.193865811164	0.505	0.491165101528	-2.7	0.218	0.443	0.084	None	None	4.02E-06	0	0	9.96E-05	0	None	0	None	4.02E-06	0	0	0	None	N	None
23446	12	D/N	rs1290459779	0.5500	gnomAD-4.0.0	14	None	0.0883	0.0992	23.7	N	0.399	0.44	0.037759	-0.068	0.1885	-0.7734	0.165591226774	1.705	0.999996	0.594	0.193865811164	0.505	0.491165101528	-2.7	0.218	0.443	0.084	None	None	1.59285E-06	0	0	4.76872E-05	0	None	0	0	1.59285E-06	0	0	0	None	N	None
23447	13	I/M	rs1213801020	0.3940	gnomAD-2.1.1	15	None	0.1496	0.1523	28.5	N	-0.694	0.25	0.020403	-0.507	0.3549	-0.262	0.354956363686	2.295	0.99342	0.577	0.43126412278	0.942	0.558844327927	-2.15	0.402	0.517	0.003	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
23447	13	I/M	rs1213801020	0.3940	gnomAD-4.0.0	15	None	0.1496	0.1523	28.5	N	-0.694	0.25	0.020403	-0.507	0.3549	-0.262	0.354956363686	2.295	0.99342	0.577	0.43126412278	0.942	0.558844327927	-2.15	0.402	0.517	0.003	None	None	4.10714E-06	0	0	0	0	None	0	0	4.10714E-06	0	5.7975E-05	1.65722E-05	None	N	None
23447	13	I/V	None	0.3940	gnomAD-4.0.0	15	None	0.0636	0.0636	23.1	N	None	0.48	0.015887	-0.708	0.0736	-1.0622	0.0716247494245	0.15	0.988544	0.528	0.261217442401	0.006	0.513706147671	-0.63	0.085	0.175	0.235	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23448	14	T/A	None	0.2856	gnomAD-4.0.0	16	None	0.1177	0.143	23.8	N	None	0.2	0.025806	-0.836	0.2318	-0.5685	0.135669409834	2.405	0.96819	0.512	0.151104730317	0.371	0.567152380943	-3.4	0.228	0.441	0.026	None	None	1.59277E-06	0	0	0	0	None	0	2.41429E-04	1.59277E-06	0	0	0	None	N	None
23448	14	T/R	None	0.2856	gnomAD-4.0.0	16	None	0.1912	0.2244	33.0	N	None	0.23	0.011965	-0.404	0.3102	-0.4644	0.465602641253	1.895	0.996519	0.545	0.568465717781	0.999	0.631378293037	-4.07	0.352	0.455	0.01	None	None	1.59278E-06	0	0	0	0	None	0	0	1.59278E-06	2.86218E-06	0	0	None	N	None
23449	15	K/N	rs957102264	0.4113	gnomAD-4.0.0	17	None	0.7462	0.7816	25.2	N	None	0.45	0.015424	0.061	0.1292	-0.8317	0.154770312983	1.985	0.998943	0.462	0.166414681773	0.919	0.558149635792	-3.47	0.15	0.318	0.01	None	None	1.20032E-06	6.33473E-05	0	0	0	None	0	0	1.20032E-06	0	0	0	None	N	None
23451	17	S/R	rs754456949	0.1320	gnomAD-3.1.2	19	None	0.8126	0.8165	29.0	N	None	0.01	0.031472	-0.546	0.4117	-0.263	0.488518040385	2.975	0.998569	0.605	0.414670632993	1.0	0.627808213234	-3.52	0.468	0.795	0.002	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
23451	17	S/R	rs754456949	0.1320	gnomAD-4.0.0	19	None	0.8126	0.8165	29.0	N	None	0.01	0.031472	-0.546	0.4117	-0.263	0.488518040385	2.975	0.998569	0.605	0.414670632993	1.0	0.627808213234	-3.52	0.468	0.795	0.002	None	None	6.57834E-06	0	0	0	0	None	0	0	6.57834E-06	1.47124E-05	0	0	None	N	None
23451	17	S/T	rs1339742394	0.1320	gnomAD-2.1.1	19	None	0.0898	0.0962	25.0	D	-0.85	0.13	0.031089	-0.836	0.2408	-0.7127	0.0936402175111	1.41	0.99976	0.577	0.156986980423	0.065	0.570892632008	-1.85	0.168	0.359	0.066	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
23451	17	S/T	rs1339742394	0.1320	gnomAD-4.0.0	19	None	0.0898	0.0962	25.0	D	-0.85	0.13	0.031089	-0.836	0.2408	-0.7127	0.0936402175111	1.41	0.99976	0.577	0.156986980423	0.065	0.570892632008	-1.85	0.168	0.359	0.066	None	None	3.18474E-06	0	0	0	0	None	0	0	3.18474E-06	0	2.8659E-05	0	None	N	None
23452	18	V/I	None	0.1133	gnomAD-4.0.0	20	None	0.0721	0.084	22.8	N	None	0.57	0.021618	-0.779	0.1234	-0.8405	0.069198310528	0.53	0.650201	0.409	0.20549828249	0.018	0.470229297876	-0.34	0.118	0.187	0.527	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23453	19	T/I	rs1435352674	0.1450	gnomAD-2.1.1	21	None	0.1235	0.1263	24.5	N	0.074	0.3	0.037097	0.115	0.1982	-0.7855	0.0940497116312	2.295	0.999996	0.533	0.255777322467	0.012	0.615118443966	-3.9	0.176	0.385	0.074	None	None	4.02E-06	0	0	0	5.58E-05	None	0	None	4.02E-06	0	0	0	None	N	None
23453	19	T/I	rs1435352674	0.1450	gnomAD-4.0.0	21	None	0.1235	0.1263	24.5	N	0.074	0.3	0.037097	0.115	0.1982	-0.7855	0.0940497116312	2.295	0.999996	0.533	0.255777322467	0.012	0.615118443966	-3.9	0.176	0.385	0.074	None	None	1.59201E-06	0	0	0	2.77654E-05	None	0	0	1.59201E-06	0	0	0	None	N	None
23453	19	T/N	None	0.1450	gnomAD-4.0.0	21	None	0.1874	0.207	26.5	N	None	0.3	0.026414	-1.372	0.341	-0.3004	0.381545519472	2.435	0.999996	0.532	0.321393169273	0.947	0.571249246597	-3.5	0.34	0.616	0.022	None	None	3.18402E-06	0	0	0	0	None	0	0	3.18402E-06	5.72037E-06	0	0	None	N	None
23457	23	D/N	None	0.3947	gnomAD-4.0.0	25	None	0.1859	0.219	25.7	N	None	0.41	0.04331	-1.095	0.1808	-0.7597	0.212132360163	0.8	0.999973	0.481	0.268211541103	0.698	0.481848299503	-3.27	0.232	0.548	0.011	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
23457	23	D/V	rs535816123	0.3947	gnomAD-2.1.1	25	None	0.5045	0.5804	32.0	N	0.436	0.36	0.058532	0.257	0.2497	-0.5766	0.403073445309	1.365	1.0	0.573	0.468834750356	0.919	0.430527836084	-5.93	0.451	0.722	0.004	None	None	2.82E-05	0	1.73893E-04	0	0	None	0	None	2.82E-05	0	8.89E-06	0	None	I	None
23457	23	D/V	rs535816123	0.3947	gnomAD-3.1.2	25	None	0.5045	0.5804	32.0	N	0.436	0.36	0.058532	0.257	0.2497	-0.5766	0.403073445309	1.365	1.0	0.573	0.468834750356	0.919	0.430527836084	-5.93	0.451	0.722	0.004	None	None	1.32E-05	0	6.56E-05	0	0	None	0	0	1.32E-05	1.47E-05	0	0	None	I	None
23457	23	D/V	rs535816123	0.3947	1000 genomes	25	None	0.5045	0.5804	32.0	N	0.436	0.36	0.058532	0.257	0.2497	-0.5766	0.403073445309	1.365	1.0	0.573	0.468834750356	0.919	0.430527836084	-5.93	0.451	0.722	0.004	None	None	1.99681E-04	0	0	None	0	1E-03	None	None	1.99681E-04	None	0	None	None	I	None
23457	23	D/V	rs535816123	0.3947	gnomAD-4.0.0	25	None	0.5045	0.5804	32.0	N	0.436	0.36	0.058532	0.257	0.2497	-0.5766	0.403073445309	1.365	1.0	0.573	0.468834750356	0.919	0.430527836084	-5.93	0.451	0.722	0.004	None	None	1.53793E-05	0	1.69509E-04	0	0	None	0	0	1.53793E-05	4.78886E-06	0	0	None	I	None
23458	24	L/F	rs1709865828	0.7789	gnomAD-4.0.0	26	None	0.1684	0.1904	26.5	N	None	0.39	0.015148	-1.033	0.1366	-0.8542	0.265924816147	1.385	0.939553	0.522	0.51754283126	0.884	0.407817929983	-2.45	0.199	0.503	0.071	None	None	1.5919E-06	0	0	0	0	None	0	0	1.5919E-06	0	0	3.02572E-05	None	I	None
23459	25	P/L	rs776457502	0.1974	gnomAD-2.1.1	27	None	0.9835	0.9916	34.0	D	-0.247	0.02	0.154668	-0.562	0.6315	0.5497	0.469722267271	4.32	1.0	0.825	0.659120768314	1.0	0.784443795681	-7.33	0.694	0.887	None	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	N	None
23459	25	P/L	rs776457502	0.1974	gnomAD-4.0.0	27	None	0.9835	0.9916	34.0	D	-0.247	0.02	0.154668	-0.562	0.6315	0.5497	0.469722267271	4.32	1.0	0.825	0.659120768314	1.0	0.784443795681	-7.33	0.694	0.887	None	None	None	4.79033E-06	0	0	0	0	None	0	0	4.79033E-06	6.29733E-06	0	0	None	N	None
23460	26	L/R	rs879027466	1.0320	gnomAD-3.1.2	28	None	0.2601	0.3396	34.0	N	None	0.48	0.058785	0.058	0.3036	-0.4422	0.473818976221	2.115	0.999999	0.483	0.547979623877	0.995	0.650712013245	-4.0	0.489	0.584	0.113	None	None	1.97E-05	7.24E-05	0	0	0	None	0	0	1.97E-05	0	0	0	None	I	None
23460	26	L/R	rs879027466	1.0320	gnomAD-4.0.0	28	None	0.2601	0.3396	34.0	N	None	0.48	0.058785	0.058	0.3036	-0.4422	0.473818976221	2.115	0.999999	0.483	0.547979623877	0.995	0.650712013245	-4.0	0.489	0.584	0.113	None	None	5.12638E-06	6.76888E-05	0	0	0	None	0	0	5.12638E-06	0	0	0	None	I	None
23461	27	I/M	None	0.3126	gnomAD-4.0.0	29	None	0.106	0.1275	23.9	N	None	0.59	0.012248	-0.415	0.1682	-0.8284	0.230854435399	2.355	0.999217	0.425	0.3571064206	0.484	0.514035105705	-1.97	0.111	0.348	0.023	None	None	1.59186E-06	0	0	0	0	None	0	0	1.59186E-06	2.8595E-06	0	0	None	I	None
23461	27	I/R	rs775762472	0.3126	gnomAD-2.1.1	29	None	0.4974	0.5352	26.2	N	0.241	0.63	0.028333	0.152	0.1624	-0.8423	0.367040416494	1.24	1.0	0.546	0.53787198782	0.484	0.596564173698	-4.6	0.326	0.453	0.031	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	0	1.65673E-04	None	I	None
23461	27	I/R	rs775762472	0.3126	gnomAD-4.0.0	29	None	0.4974	0.5352	26.2	N	0.241	0.63	0.028333	0.152	0.1624	-0.8423	0.367040416494	1.24	1.0	0.546	0.53787198782	0.484	0.596564173698	-4.6	0.326	0.453	0.031	None	None	1.59189E-06	0	0	0	0	None	0	0	1.59189E-06	0	1.43303E-05	0	None	I	None
23461	27	I/V	rs1170300318	0.3126	gnomAD-2.1.1	29	None	0.0986	0.0903	22.5	N	-0.205	0.63	0.009412	-0.375	0.0785	-1.0736	0.0710446202875	0.815	0.992995	0.397	0.257292322809	None	0.460335433483	-0.65	0.037	0.107	0.106	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	I	None
23461	27	I/V	rs1170300318	0.3126	gnomAD-4.0.0	29	None	0.0986	0.0903	22.5	N	-0.205	0.63	0.009412	-0.375	0.0785	-1.0736	0.0710446202875	0.815	0.992995	0.397	0.257292322809	None	0.460335433483	-0.65	0.037	0.107	0.106	None	None	3.18369E-06	0	4.57352E-05	0	0	None	0	0	3.18369E-06	0	0	0	None	I	None
23462	28	D/N	None	0.3595	gnomAD-4.0.0	30	None	0.5579	0.6203	27.1	N	None	0.32	0.028741	-0.349	0.4299	-0.1578	0.457538867752	2.14	1.0	0.499	0.502629187243	1.0	0.661507964134	-3.67	0.399	0.685	None	None	None	1.36861E-06	0	0	0	0	None	0	0	1.36861E-06	0	2.31895E-05	0	None	I	None
23463	29	G/A	rs745946955	0.1088	gnomAD-2.1.1	31	None	0.9725	0.9849	28.2	D	-0.303	0.36	0.109813	-0.389	0.5509	0.4229	0.481701296431	3.39	1.0	0.661	0.404733080969	1.0	0.640042901039	-4.4	0.536	0.733	None	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.89E-06	0	None	I	None
23463	29	G/A	rs745946955	0.1088	gnomAD-4.0.0	31	None	0.9725	0.9849	28.2	D	-0.303	0.36	0.109813	-0.389	0.5509	0.4229	0.481701296431	3.39	1.0	0.661	0.404733080969	1.0	0.640042901039	-4.4	0.536	0.733	None	None	None	1.59179E-06	0	0	0	0	None	0	0	1.59179E-06	2.8593E-06	0	0	None	I	None
23464	30	G/A	None	0.2600	gnomAD-4.0.0	32	None	0.8659	0.91	28.3	N	None	0.19	0.028621	-0.196	0.4927	0.0821	0.48046466691	2.78	1.0	0.628	0.462200489575	0.998	0.57069426775	-4.4	0.516	0.624	None	None	None	1.36861E-06	0	0	0	0	None	0	0	1.36861E-06	1.79913E-06	0	0	None	I	None
23464	30	G/D	rs549938348	0.2600	1000 genomes	32	None	0.9902	0.9915	29.2	D	-0.186	0.14	0.139261	-0.341	0.5557	0.3416	0.527275360279	4.1	1.0	0.635	0.562844193612	1.0	0.672911942005	-5.13	0.599	0.709	None	None	None	1.99681E-04	8E-04	0	None	0	0	None	None	1.99681E-04	None	0	None	None	I	None
23464	30	G/D	rs549938348	0.2600	gnomAD-4.0.0	32	None	0.9902	0.9915	29.2	D	-0.186	0.14	0.139261	-0.341	0.5557	0.3416	0.527275360279	4.1	1.0	0.635	0.562844193612	1.0	0.672911942005	-5.13	0.599	0.709	None	None	None	6.84303E-07	2.98864E-05	0	0	0	None	0	0	6.84303E-07	0	0	0	None	I	None
23464	30	G/R	None	0.2600	gnomAD-4.0.0	32	None	0.9852	0.9891	27.2	N	None	0.13	0.156731	-0.152	0.5138	0.1682	0.506463245118	2.795	1.0	0.652	0.635404382416	1.0	0.657438516617	-5.87	0.577	0.808	None	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
23464	30	G/V	rs549938348	0.2600	gnomAD-2.1.1	32	None	0.9761	0.9852	29.2	D	-0.088	0.14	0.31271	-0.314	0.5969	0.5072	0.518063289252	4.445	1.0	0.639	0.751764722199	1.0	0.584443807602	-6.6	0.599	0.804	None	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	I	None
23464	30	G/V	rs549938348	0.2600	gnomAD-3.1.2	32	None	0.9761	0.9852	29.2	D	-0.088	0.14	0.31271	-0.314	0.5969	0.5072	0.518063289252	4.445	1.0	0.639	0.751764722199	1.0	0.584443807602	-6.6	0.599	0.804	None	None	None	1.32E-05	0	6.56E-05	0	0	None	0	0	1.32E-05	1.47E-05	0	0	None	I	None
23464	30	G/V	rs549938348	0.2600	gnomAD-4.0.0	32	None	0.9761	0.9852	29.2	D	-0.088	0.14	0.31271	-0.314	0.5969	0.5072	0.518063289252	4.445	1.0	0.639	0.751764722199	1.0	0.584443807602	-6.6	0.599	0.804	None	None	None	6.81791E-06	0	3.33556E-05	0	0	None	0	0	6.81791E-06	5.93398E-06	0	3.20297E-05	None	I	None
23466	32	R/C	rs749744742	0.8526	gnomAD-2.1.1	34	None	0.3573	0.3555	29.8	N	-0.049	0.39	0.021922	-0.207	0.2633	-0.5714	0.441007753719	2.01	0.998598	0.597	0.34854441366	0.996	0.402851998806	-5.07	0.4	0.443	0.007	None	None	1.07E-05	4.13E-05	0	0	0	None	0	None	1.07E-05	0	1.56E-05	0	None	I	None
23466	32	R/C	rs749744742	0.8526	gnomAD-3.1.2	34	None	0.3573	0.3555	29.8	N	-0.049	0.39	0.021922	-0.207	0.2633	-0.5714	0.441007753719	2.01	0.998598	0.597	0.34854441366	0.996	0.402851998806	-5.07	0.4	0.443	0.007	None	None	1.97E-05	2.42E-05	6.56E-05	0	0	None	0	0	1.97E-05	1.47E-05	0	0	None	I	None
23466	32	R/C	rs749744742	0.8526	gnomAD-4.0.0	34	None	0.3573	0.3555	29.8	N	-0.049	0.39	0.021922	-0.207	0.2633	-0.5714	0.441007753719	2.01	0.998598	0.597	0.34854441366	0.996	0.402851998806	-5.07	0.4	0.443	0.007	None	None	8.67778E-06	1.33618E-05	1.66756E-05	0	0	None	0	0	8.67778E-06	1.01727E-05	0	0	None	I	None
23466	32	R/G	None	0.8526	gnomAD-4.0.0	34	None	0.5574	0.5435	24.8	N	None	0.44	0.026254	-0.105	0.1346	-0.7735	0.225707876829	0.86	0.692566	0.575	0.272639205421	0.579	0.3316642344	-4.38	0.278	0.54	0.046	None	None	6.84309E-07	0	0	0	0	None	0	0	6.84309E-07	8.99565E-07	0	0	None	I	None
23466	32	R/H	rs1193026411	0.8526	gnomAD-2.1.1	34	None	0.183	0.1709	24.6	N	-0.582	0.44	0.011886	-0.608	0.0967	-0.978	0.107435418046	0.36	0.666006	0.534	0.18274738541	0.009	0.339452147484	-3.15	0.122	0.303	0.041	None	None	8.05E-06	0	0	0	0	None	3.27E-05	None	8.05E-06	0	0	1.65837E-04	None	I	None
23466	32	R/H	rs1193026411	0.8526	gnomAD-4.0.0	34	None	0.183	0.1709	24.6	N	-0.582	0.44	0.011886	-0.608	0.0967	-0.978	0.107435418046	0.36	0.666006	0.534	0.18274738541	0.009	0.339452147484	-3.15	0.122	0.303	0.041	None	None	1.0949E-05	0	0	0	0	None	0	0	1.0949E-05	1.07949E-05	2.31895E-05	3.31389E-05	None	I	None
23466	32	R/P	None	0.8526	gnomAD-4.0.0	34	None	0.467	0.4547	24.9	N	None	0.64	0.011625	0.283	0.0385	-1.0714	0.12573545356	-1.59	0.846572	0.579	0.12205267543	0.004	0.361167013645	-3.93	0.266	0.291	0.134	None	None	6.84315E-07	0	0	0	0	None	0	0	6.84315E-07	8.99572E-07	0	0	None	I	None
23466	32	R/S	rs749744742	0.8526	gnomAD-4.0.0	34	None	0.7487	0.7329	24.4	N	None	0.49	0.021231	-0.218	0.1199	-0.8177	0.181545404826	0.625	0.700022	0.539	0.223146558224	0.579	0.337781995535	-3.52	0.233	0.497	0.068	None	None	1.36862E-06	2.98882E-05	0	0	0	None	0	1.73551E-04	1.36862E-06	0	0	0	None	I	None
23467	33	I/M	None	0.2184	gnomAD-4.0.0	35	None	0.6591	0.6792	26.7	D	None	0.04	0.031546	-0.921	0.4443	-0.1989	0.325946002528	3.64	0.998522	0.653	0.618565862433	0.95	0.689602553844	-2.15	0.408	0.706	0.002	None	None	1.59181E-06	0	0	0	0	None	1.88253E-05	0	1.59181E-06	0	0	0	None	I	None
23467	33	I/T	rs778170654	0.2184	gnomAD-2.1.1	35	None	0.9694	0.9745	26.3	N	-2.389	0.03	0.042022	-2.121	0.4318	0.0459	0.288925313761	3.525	0.999999	0.68	0.765417107005	0.87	0.802234649658	-3.57	0.497	0.796	0.002	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	I	None
23467	33	I/V	rs866974760	0.2184	gnomAD-4.0.0	35	None	0.1068	0.1169	22.9	N	None	0.21	0.011532	-1.555	0.1305	-0.981	0.0710446202875	0.78	0.999799	0.572	0.369682402691	0.001	0.640308082104	-0.63	0.079	0.253	0.095	None	None	2.05293E-06	0	0	0	0	None	0	3.47102E-04	2.05293E-06	0	0	1.65695E-05	None	I	None
23468	34	T/K	None	0.3562	gnomAD-4.0.0	36	None	0.2692	0.2555	25.4	N	None	0.29	0.038501	-0.846	0.1519	-0.9265	0.109108561739	1.1	0.999648	0.652	0.266843984389	0.134	0.697760224342	-3.12	0.252	0.21	0.226	None	None	1.59179E-06	0	0	0	0	None	0	0	1.59179E-06	2.85919E-06	0	0	None	I	None
23470	36	Y/C	rs750891099	0.1370	gnomAD-2.1.1	38	None	0.9529	0.9575	34.0	D	-2.243	-1.18	0.129245	-2.162	0.8118	0.9684	0.517873433737	4.715	1.0	0.889	0.858315805586	1.0	0.779499650002	-6.47	0.858	0.877	None	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	N	None
23470	36	Y/C	rs750891099	0.1370	gnomAD-4.0.0	38	None	0.9529	0.9575	34.0	D	-2.243	-1.18	0.129245	-2.162	0.8118	0.9684	0.517873433737	4.715	1.0	0.889	0.858315805586	1.0	0.779499650002	-6.47	0.858	0.877	None	None	None	1.84762E-05	0	0	0	0	None	0	0	1.84762E-05	2.33884E-05	0	1.65695E-05	None	N	None
23470	36	Y/D	rs753051564	0.1370	gnomAD-2.1.1	38	None	0.998	0.9988	33.0	D	-4.126	-1.2	0.149586	-3.714	0.8118	0.9684	0.61613149071	4.715	1.0	0.893	0.937448696552	1.0	0.775059700012	-7.2	0.857	0.909	None	None	None	4.03E-06	0	2.9E-05	0	0	None	0	None	4.03E-06	0	0	0	None	N	None
23470	36	Y/D	rs753051564	0.1370	gnomAD-4.0.0	38	None	0.998	0.9988	33.0	D	-4.126	-1.2	0.149586	-3.714	0.8118	0.9684	0.61613149071	4.715	1.0	0.893	0.937448696552	1.0	0.775059700012	-7.2	0.857	0.909	None	None	None	1.59176E-06	0	2.28676E-05	0	0	None	0	0	1.59176E-06	0	0	0	None	N	None
23471	37	I/M	rs764793576	0.1933	gnomAD-2.1.1	39	None	0.3167	0.3454	25.9	N	-1.382	0.4	0.015588	-1.144	0.2873	-0.5707	0.44241232491	2.94	0.987684	0.36	0.550334908387	0.99	0.559698939323	-2.17	0.339	0.703	0.003	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	N	None
23471	37	I/T	rs1475765674	0.1933	gnomAD-3.1.2	39	None	0.4548	0.4876	31.0	N	None	0.5	0.022998	-2.383	0.3017	-0.4562	0.462219461291	1.875	0.999982	0.383	0.70371367467	0.972	0.698388159275	-3.6	0.414	0.663	0.091	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
23471	37	I/T	rs1475765674	0.1933	gnomAD-4.0.0	39	None	0.4548	0.4876	31.0	N	None	0.5	0.022998	-2.383	0.3017	-0.4562	0.462219461291	1.875	0.999982	0.383	0.70371367467	0.972	0.698388159275	-3.6	0.414	0.663	0.091	None	None	4.33881E-06	0	0	0	0	None	0	0	4.33881E-06	5.934E-06	0	0	None	N	None
23471	37	I/V	None	0.1933	gnomAD-4.0.0	39	None	0.0823	0.0863	23.9	N	None	0.46	0.00793	-1.637	0.1179	-0.9944	0.0759569308348	0.955	0.993502	0.289	0.470890129789	0.006	0.514743208885	-0.67	0.06	0.281	0.066	None	None	1.20033E-06	0	0	0	0	None	0	0	1.20033E-06	1.31251E-06	0	0	None	N	None
23472	38	V/I	rs556399127	0.1028	gnomAD-2.1.1	40	None	0.0733	0.0733	22.2	N	-0.706	0.17	0.018609	-0.637	0.1568	-0.9253	0.0767185883067	0.18	0.997834	0.506	0.473065174198	0.29	0.390363752842	-0.39	0.153	0.213	0.427	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.9E-06	0	None	N	None
23472	38	V/I	rs556399127	0.1028	gnomAD-4.0.0	40	None	0.0733	0.0733	22.2	N	-0.706	0.17	0.018609	-0.637	0.1568	-0.9253	0.0767185883067	0.18	0.997834	0.506	0.473065174198	0.29	0.390363752842	-0.39	0.153	0.213	0.427	None	None	3.18349E-06	0	0	0	2.77809E-05	None	0	0	3.18349E-06	2.8591E-06	0	0	None	N	None
23473	39	E/Q	None	0.1182	gnomAD-4.0.0	41	None	0.5578	0.5567	32.0	N	None	0.4	0.021039	-1.509	0.3444	-0.3951	0.462113211876	1.78	1.0	0.546	0.27479166964	1.0	0.625901460648	-2.0	0.316	0.764	0.006	None	None	1.59176E-06	0	0	0	0	None	0	0	1.59176E-06	2.85914E-06	0	0	None	N	None
23474	40	K/E	None	0.2456	gnomAD-4.0.0	42	None	0.8982	0.9235	31.0	N	None	0.38	0.053942	-1.29	0.3651	-0.0744	0.400010837408	3.525	0.999998	0.574	0.329540904979	0.982	0.690916419029	-2.9	0.445	0.699	0.013	None	None	1.59175E-06	0	0	0	0	None	0	0	1.59175E-06	2.8591E-06	0	0	None	N	None
23475	41	R/C	rs761442543	0.1122	gnomAD-2.1.1	43	None	0.8427	0.875	35.0	N	-2.027	0.27	0.027648	-2.088	0.4114	-0.0898	0.529946208568	2.345	1.0	0.711	0.612445847935	1.0	0.672203063965	-5.77	0.471	0.754	None	None	None	2.5E-05	0	2.83E-05	0	0	None	3.27E-05	None	2.5E-05	0	3.13E-05	1.40489E-04	None	N	None
23475	41	R/C	rs761442543	0.1122	gnomAD-3.1.2	43	None	0.8427	0.875	35.0	N	-2.027	0.27	0.027648	-2.088	0.4114	-0.0898	0.529946208568	2.345	1.0	0.711	0.612445847935	1.0	0.672203063965	-5.77	0.471	0.754	None	None	None	3.29E-05	0	6.56E-05	0	0	None	0	0	3.29E-05	5.88E-05	0	0	None	N	None
23475	41	R/C	rs761442543	0.1122	gnomAD-4.0.0	43	None	0.8427	0.875	35.0	N	-2.027	0.27	0.027648	-2.088	0.4114	-0.0898	0.529946208568	2.345	1.0	0.711	0.612445847935	1.0	0.672203063965	-5.77	0.471	0.754	None	None	None	2.66528E-05	0	3.33545E-05	0	0	None	0	0	2.66528E-05	3.39089E-05	1.09796E-05	0	None	N	None
23475	41	R/H	rs370257707	0.1122	gnomAD-2.1.1	43	None	0.791	0.8154	None	N	-2.676	None	None	-2.383	None	None	None	None	None	None	None	0.999	None	None	0.41	0.587	None	None	None	3.22E-05	8.27E-05	0	0	5.15E-05	None	0	None	3.22E-05	0	4.7E-05	0	None	N	None
23475	41	R/H	rs370257707	0.1122	gnomAD-3.1.2	43	None	0.791	0.8154	None	N	-2.676	None	None	-2.383	None	None	None	None	None	None	None	0.999	None	None	0.41	0.587	None	None	None	3.95E-05	2.41E-05	0	0	0	None	0	0	3.95E-05	7.36E-05	0	0	None	N	None
23475	41	R/H	rs370257707	0.1122	gnomAD-4.0.0	43	None	0.791	0.8154	None	N	-2.676	None	None	-2.383	None	None	None	None	None	None	None	0.999	None	None	0.41	0.587	None	None	None	7.37575E-05	1.33526E-05	0	0	2.23254E-05	None	0	0	7.37575E-05	9.40973E-05	0	9.6083E-05	None	N	None
23477	43	A/E	None	0.2369	gnomAD-4.0.0	50	None	0.7277	0.7084	27.8	N	None	0.46	0.022827	-0.908	0.1688	-0.7878	0.267356887122	1.63	0.994692	0.439	0.353548585375	0.822	0.475727617741	-3.1	0.28	0.511	0.019	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23477	43	A/T	rs763988813	0.2369	gnomAD-2.1.1	50	None	0.1183	0.132	25.3	N	-1.129	0.45	0.016362	-1.075	0.1232	-0.8695	0.207818169212	0.995	0.925713	0.33	0.241078983079	0.698	0.422848790884	-2.33	0.096	0.533	0.027	None	None	2.01E-05	0	0	0	0	None	1.6342E-04	None	2.01E-05	0	0	0	None	N	None
23477	43	A/T	rs763988813	0.2369	gnomAD-4.0.0	50	None	0.1183	0.132	25.3	N	-1.129	0.45	0.016362	-1.075	0.1232	-0.8695	0.207818169212	0.995	0.925713	0.33	0.241078983079	0.698	0.422848790884	-2.33	0.096	0.533	0.027	None	None	8.21163E-06	0	0	0	0	None	0	0	8.21163E-06	1.79911E-06	1.15945E-04	0	None	N	None
23479	45	R/Q	rs140127488	0.4740	gnomAD-2.1.1	60	None	0.3477	0.3334	None	N	0.072	None	None	-0.311	None	None	None	None	None	None	None	0.998	None	None	0.244	0.36	None	None	None	1.21E-05	0	0	0	0	None	3.27E-05	None	1.21E-05	0	1.78E-05	0	None	N	None
23479	45	R/Q	rs140127488	0.4740	gnomAD-3.1.2	60	None	0.3477	0.3334	None	N	0.072	None	None	-0.311	None	None	None	None	None	None	None	0.998	None	None	0.244	0.36	None	None	None	6.58E-06	0	0	0	1.94099E-04	None	0	0	6.58E-06	0	0	0	None	N	None
23479	45	R/Q	rs140127488	0.4740	1000 genomes	60	None	0.3477	0.3334	None	N	0.072	None	None	-0.311	None	None	None	None	None	None	None	0.998	None	None	0.244	0.36	None	None	None	1.99681E-04	0	0	None	1E-03	0	None	None	1.99681E-04	None	0	None	None	N	None
23479	45	R/Q	rs140127488	0.4740	gnomAD-4.0.0	60	None	0.3477	0.3334	None	N	0.072	None	None	-0.311	None	None	None	None	None	None	None	0.998	None	None	0.244	0.36	None	None	None	1.54944E-05	1.33316E-05	0	0	2.23454E-05	None	0	0	1.54944E-05	1.69545E-05	3.29417E-05	0	None	N	None
23479	45	R/W	rs760509116	0.4740	gnomAD-2.1.1	60	None	0.6242	0.6303	27.3	N	-0.376	0.37	0.025785	-0.501	0.3395	-0.3375	0.458681709055	2.53	0.999907	0.469	0.370424759081	1.0	0.581686854362	-5.87	0.328	0.647	0.001	None	None	6.08E-05	4.13E-05	3.67876E-04	0	0	None	0	None	6.08E-05	0	2.35E-05	0	None	N	None
23479	45	R/W	rs760509116	0.4740	gnomAD-3.1.2	60	None	0.6242	0.6303	27.3	N	-0.376	0.37	0.025785	-0.501	0.3395	-0.3375	0.458681709055	2.53	0.999907	0.469	0.370424759081	1.0	0.581686854362	-5.87	0.328	0.647	0.001	None	None	3.29E-05	0	1.96773E-04	0	0	None	0	0	3.29E-05	2.94E-05	0	0	None	N	None
23479	45	R/W	rs760509116	0.4740	gnomAD-4.0.0	60	None	0.6242	0.6303	27.3	N	-0.376	0.37	0.025785	-0.501	0.3395	-0.3375	0.458681709055	2.53	0.999907	0.469	0.370424759081	1.0	0.581686854362	-5.87	0.328	0.647	0.001	None	None	3.09884E-05	3.99957E-05	3.16772E-04	0	0	None	0	0	3.09884E-05	1.86498E-05	2.19602E-05	6.40307E-05	None	N	None
23480	46	K/Q	None	1.0609	gnomAD-4.0.0	63	None	0.6784	0.6103	31.0	N	None	0.48	0.017888	-0.289	0.3287	-0.3666	0.462538365587	2.21	1.0	0.341	0.291694819147	0.999	0.619305849075	-2.93	0.252	0.65	0.01	None	None	1.59177E-06	0	0	0	0	None	0	0	1.59177E-06	2.85907E-06	0	0	None	N	None
23482	48	Y/F	None	0.2103	gnomAD-4.0.0	65	None	0.1008	0.0979	33.0	N	None	0.45	0.006646	-1.324	0.1826	-0.7849	0.355003799051	0.655	0.999865	0.472	0.415690173769	0.965	0.573883891106	-2.55	0.279	0.47	0.183	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
23483	49	S/Y	None	0.3673	gnomAD-4.0.0	66	None	0.342	0.3551	28.1	N	None	0.38	0.047722	-0.767	0.2499	-0.6059	0.286892952516	2.215	0.999985	0.477	0.581503058331	0.932	0.483966648579	-4.03	0.408	0.383	0.007	None	None	1.59171E-06	0	0	0	0	None	0	0	1.59171E-06	2.85904E-06	0	0	None	N	None
23484	50	T/K	rs1178437079	0.4412	gnomAD-2.1.1	67	None	0.5344	0.4973	25.3	N	-0.547	0.38	0.031746	-0.643	0.1652	-0.7593	0.199647858005	1.235	0.99945	0.442	0.353125101423	0.65	0.453341931105	-3.97	0.173	0.463	0.061	None	None	4.02E-06	0	0	0	5.59E-05	None	0	None	4.02E-06	0	0	0	None	N	None
23484	50	T/K	rs1178437079	0.4412	gnomAD-4.0.0	67	None	0.5344	0.4973	25.3	N	-0.547	0.38	0.031746	-0.643	0.1652	-0.7593	0.199647858005	1.235	0.99945	0.442	0.353125101423	0.65	0.453341931105	-3.97	0.173	0.463	0.061	None	None	6.84284E-07	0	0	0	2.52283E-05	None	0	0	6.84284E-07	0	0	0	None	N	None
23484	50	T/R	None	0.4412	gnomAD-4.0.0	67	None	0.4799	0.4393	28.0	N	None	0.4	0.025971	-0.312	0.2306	-0.6158	0.370627674417	1.925	0.999648	0.434	0.427940940899	0.972	0.442029207945	-4.03	0.312	0.533	0.009	None	None	6.84284E-07	0	0	0	0	None	0	0	6.84284E-07	8.99546E-07	0	0	None	N	None
23485	51	A/D	None	0.2199	gnomAD-4.0.0	68	None	0.6558	0.7047	22.1	N	None	0.41	0.031886	-0.857	0.1686	-0.7908	0.19791807694	1.875	0.994018	0.606	0.117506650769	0.295	0.343706429005	-2.76	0.148	0.527	0.001	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
23486	52	T/I	rs774575929	0.1473	gnomAD-2.1.1	69	None	0.2721	0.2955	24.9	N	-0.084	0.3	0.019011	-0.297	0.2668	-0.4533	0.193807588903	0.91	0.943044	0.546	0.319114376414	0.497	0.555314362049	-3.53	0.163	0.621	0.202	None	None	8.05E-06	0	2.9E-05	0	5.59E-05	None	0	None	8.05E-06	0	0	0	None	N	None
23486	52	T/I	rs774575929	0.1473	gnomAD-4.0.0	69	None	0.2721	0.2955	24.9	N	-0.084	0.3	0.019011	-0.297	0.2668	-0.4533	0.193807588903	0.91	0.943044	0.546	0.319114376414	0.497	0.555314362049	-3.53	0.163	0.621	0.202	None	None	2.05284E-06	0	2.23634E-05	0	5.04566E-05	None	0	0	2.05284E-06	0	0	0	None	N	None
23487	53	T/I	None	0.5105	gnomAD-4.0.0	70	None	0.383	0.3334	31.0	N	None	0.52	0.019815	-0.296	0.3433	-0.3734	0.44106558447	3.035	1.0	0.391	0.39162414616	0.983	0.665994405746	-4.27	0.355	0.76	0.006	None	None	2.73715E-06	0	0	0	0	None	0	0	2.73715E-06	2.69865E-06	1.15947E-05	0	None	N	None
23487	53	T/S	None	0.5105	gnomAD-4.0.0	70	None	0.1392	0.1116	25.0	N	None	0.41	0.024637	-0.627	0.1282	-0.9742	0.0824423413345	1.51	1.0	0.492	0.124217242631	0.008	0.563793301582	-2.77	0.124	0.307	0.101	None	None	6.84287E-07	0	0	0	0	None	0	0	6.84287E-07	8.99549E-07	0	0	None	N	None
23488	54	K/E	None	0.8363	gnomAD-4.0.0	75	None	0.1988	0.2206	24.8	N	None	0.42	0.013389	-0.027	0.1078	-0.8936	0.157787249233	1.115	0.864986	0.537	0.197625483188	0.166	0.476592808962	-2.27	0.215	0.132	0.153	None	None	1.36858E-06	0	0	0	0	None	0	0	1.36858E-06	1.7991E-06	0	0	None	N	None
23488	54	K/R	None	0.8363	gnomAD-4.0.0	75	None	0.0824	0.081	27.7	N	None	0.36	0.018472	0.159	0.1566	-0.6762	0.0979166354652	1.63	0.747486	0.484	0.166414681773	0.166	0.431744605303	-1.77	0.106	0.162	0.03	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23489	55	C/F	None	0.1046	gnomAD-4.0.0	77	None	0.6756	0.7278	26.0	N	None	0.44	0.036223	-1.24	0.3332	-0.1021	0.342277123456	2.665	1.0	0.454	0.78313215989	0.991	0.677575469017	-6.55	0.429	0.584	0.013	None	None	3.42146E-06	0	0	0	0	None	0	0	3.42146E-06	4.49777E-06	0	0	None	N	None
23489	55	C/S	rs1471554561	0.1046	gnomAD-2.1.1	77	None	0.6335	0.6568	25.3	N	-2.219	0.56	0.028351	-2.057	0.3132	-0.3821	0.272465490003	1.73	0.999999	0.5	0.601175442443	0.962	0.670109033585	-6.28	0.353	0.554	0.006	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
23490	56	H/D	rs1397554911	0.7122	gnomAD-3.1.2	83	None	0.2254	0.2104	27.0	N	None	0.51	0.019944	0.143	0.1346	-0.8984	0.139587601779	0.455	0.992782	0.515	0.154104182512	0.255	0.579184949398	-4.55	0.218	0.209	0.134	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
23490	56	H/D	rs1397554911	0.7122	gnomAD-4.0.0	83	None	0.2254	0.2104	27.0	N	None	0.51	0.019944	0.143	0.1346	-0.8984	0.139587601779	0.455	0.992782	0.515	0.154104182512	0.255	0.579184949398	-4.55	0.218	0.209	0.134	None	None	3.84475E-06	1.69291E-05	0	0	0	None	0	0	3.84475E-06	2.39383E-06	0	2.84511E-05	None	N	None
23493	59	T/I	None	0.3158	gnomAD-4.0.0	90	None	0.18	0.1871	29.1	N	None	0.27	0.024537	0.01	0.2506	-0.5068	0.246670485079	2.19	0.997658	0.473	0.385906861911	0.815	0.593385279179	-3.68	0.336	0.516	0.015	None	None	6.00161E-06	0	0	0	0	None	0	0	6.00161E-06	6.56251E-06	0	0	None	N	None
23493	59	T/S	rs375675901	0.3158	gnomAD-3.1.2	90	None	0.0744	0.0812	None	N	None	None	None	-1.33	None	None	None	None	None	None	None	0.004	None	None	0.093	0.188	None	None	None	2.63E-05	9.65E-05	0	0	0	None	0	0	2.63E-05	0	0	0	None	N	None
23493	59	T/S	rs375675901	0.3158	gnomAD-4.0.0	90	None	0.0744	0.0812	None	N	None	None	None	-1.33	None	None	None	None	None	None	None	0.004	None	None	0.093	0.188	None	None	None	7.43708E-06	6.67485E-05	0	0	0	None	0	0	7.43708E-06	5.08613E-06	0	1.60128E-05	None	N	None
23494	60	Y/H	rs72646888	0.2637	gnomAD-4.0.0	91	None	0.2608	0.3034	24.0	N	None	0.21	0.024573	-0.886	0.2321	-0.713	0.299399194133	2.035	0.999523	0.759	0.384752662912	0.741	0.644811749458	-3.43	0.291	0.539	None	None	None	6.84286E-06	0	0	0	0	None	0	0	6.84286E-06	8.09597E-06	0	1.65684E-05	None	N	None
23494	60	Y/N	None	0.2637	gnomAD-4.0.0	91	None	0.4723	0.5868	24.0	N	None	0.17	0.054078	-1.712	0.3019	-0.4901	0.303645760765	3.355	0.994681	0.761	0.683845495215	0.484	0.638451457024	-6.03	0.429	0.615	None	None	None	6.84286E-07	0	0	0	0	None	0	0	6.84286E-07	8.99552E-07	0	0	None	N	None
23495	61	K/E	None	0.3814	gnomAD-4.0.0	92	None	0.3959	0.4275	26.6	N	None	0.45	0.027653	0.171	0.1637	-0.7624	0.207269236385	2.13	0.989076	0.575	0.245101548738	0.87	0.56749689579	-2.67	0.215	0.541	0.007	None	None	3.18337E-06	0	0	0	0	None	0	0	3.18337E-06	0	2.86607E-05	0	None	N	None
23495	61	K/N	rs1482776876	0.3814	gnomAD-2.1.1	92	None	0.7114	0.7582	29.2	N	-0.244	0.42	0.032702	-0.376	0.2332	-0.6425	0.385420460955	2.45	0.645829	0.558	0.143124449307	0.987	0.591079950333	-3.27	0.263	0.662	0.005	None	None	2.01E-05	6.46E-05	0	0	0	None	0	None	2.01E-05	0	3.56E-05	0	None	N	None
23495	61	K/N	rs1482776876	0.3814	gnomAD-4.0.0	92	None	0.7114	0.7582	29.2	N	-0.244	0.42	0.032702	-0.376	0.2332	-0.6425	0.385420460955	2.45	0.645829	0.558	0.143124449307	0.987	0.591079950333	-3.27	0.263	0.662	0.005	None	None	1.437E-05	2.98829E-05	0	0	0	None	0	0	1.437E-05	1.52924E-05	0	4.97051E-05	None	N	None
23496	62	V/L	None	0.1444	gnomAD-4.0.0	93	None	0.2099	0.2456	24.4	N	None	0.48	0.024071	-0.221	0.1669	-0.7953	0.101163379773	1.92	0.982854	0.502	0.413891365518	0.244	0.632769525051	-1.87	0.126	0.532	0.013	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23497	63	T/I	None	0.5598	gnomAD-4.0.0	94	None	0.1144	0.1221	26.1	N	None	0.22	0.026012	-0.276	0.3719	-0.2436	0.364039194869	2.14	0.999237	0.48	0.409665357357	0.966	0.593774914742	-3.7	0.351	0.575	0.039	None	None	1.5917E-06	0	0	0	0	None	0	0	1.5917E-06	2.85915E-06	0	0	None	N	None
23498	64	G/D	rs770261949	0.4495	gnomAD-2.1.1	96	None	0.1342	0.1471	23.4	N	0.126	0.47	0.010256	-0.172	0.0959	-0.9542	0.110646270925	0.135	0.632133	0.679	0.159798565429	None	0.491168826818	-2.73	0.076	0.233	0.463	None	None	4.02E-06	0	0	0	5.58E-05	None	0	None	4.02E-06	0	0	0	None	N	None
23498	64	G/S	rs370771532	0.4495	gnomAD-2.1.1	96	None	0.0884	0.0934	None	N	-0.149	None	None	-0.495	None	None	None	None	None	None	None	0.442	None	None	0.154	0.399	None	None	None	2.32246E-04	4.54658E-04	0	4.06425E-03	0	None	3.27E-05	None	2.32246E-04	0	7.82E-05	1.40568E-04	None	N	None
23498	64	G/S	rs370771532	0.4495	gnomAD-3.1.2	96	None	0.0884	0.0934	None	N	-0.149	None	None	-0.495	None	None	None	None	None	None	None	0.442	None	None	0.154	0.399	None	None	None	2.43328E-04	3.86138E-04	0	3.4642E-03	0	None	0	0	2.43328E-04	1.32372E-04	0	0	None	N	None
23498	64	G/S	rs370771532	0.4495	gnomAD-4.0.0	96	None	0.0884	0.0934	None	N	-0.149	None	None	-0.495	None	None	None	None	None	None	None	0.442	None	None	0.154	0.399	None	None	None	1.80983E-04	2.93733E-04	0	3.27858E-03	0	None	0	0	1.80983E-04	1.30548E-04	2.19631E-05	2.72253E-04	None	N	None
23499	65	L/F	rs75626265	0.1422	gnomAD-4.0.0	97	None	0.7595	0.7924	25.5	D	-2.286	-1.91	0.077293	-1.898	0.8152	0.758	0.482941457244	4.17	0.718443	0.753	0.850636553644	1.0	0.558287501335	-2.93	0.645	0.855	0.005	None	None	6.37414E-05	5.65803E-05	0	0	3.06407E-04	None	4.93246E-04	0	6.37414E-05	0	0	6.06428E-05	None	N	None
23499	65	L/S	None	0.1422	gnomAD-4.0.0	97	None	0.993	0.995	33.0	D	None	-1.95	0.141851	-2.577	0.8696	0.9216	0.544358781492	4.72	0.999851	0.774	0.901367598863	1.0	0.594133973122	-4.4	0.768	0.826	0.001	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23500	66	S/C	rs774745687	0.4656	gnomAD-4.0.0	98	None	0.1026	0.0994	24.1	N	None	0.36	0.030129	-0.347	0.1815	-0.8321	0.243888544257	2.02	1.0	0.52	0.341696514166	0.78	0.327316880226	-2.58	0.208	0.351	0.058	None	None	3.1837E-06	0	0	0	0	None	0	0	3.1837E-06	5.7186E-06	0	0	None	N	None
23500	66	S/T	None	0.4656	gnomAD-4.0.0	98	None	0.0611	0.0601	20.5	N	None	0.49	0.005109	-0.386	0.059	-0.978	0.0768623292415	0.51	1.0	0.409	0.0297737177859	None	0.325867027044	-0.27	0.068	0.065	0.863	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	0	3.66327E-05	None	N	None
23501	67	E/K	rs1709809170	0.6558	gnomAD-4.0.0	99	None	0.4001	0.4763	27.4	N	None	0.37	0.019494	0.569	0.3608	-0.3382	0.486089516762	2.615	1.0	0.622	0.48087575253	0.997	0.639372944832	-2.93	0.361	0.71	None	None	None	4.77544E-06	0	2.28655E-05	0	0	None	0	0	4.77544E-06	0	2.86615E-05	0	None	N	None
23502	68	G/A	rs755417099	0.3223	gnomAD-4.0.0	100	None	0.4999	0.4625	25.7	N	None	0.04	0.021758	-0.433	0.2838	-0.5731	0.0972151611059	2.395	0.999999	0.618	0.365120060079	0.057	0.635633170605	-3.73	0.286	0.45	0.12	None	None	1.59176E-06	0	0	0	0	None	0	0	1.59176E-06	2.85925E-06	0	0	None	N	None
23502	68	G/E	rs755417099	0.3223	gnomAD-2.1.1	100	None	0.7991	0.7506	32.0	N	-1.018	0.04	0.036661	-1.024	0.4803	0.0873	0.421294858915	3.025	1.0	0.67	0.617086127331	0.951	0.693202733994	-5.4	0.417	0.819	0.002	None	None	1.21E-05	0	0	0	1.67504E-04	None	0	None	1.21E-05	0	0	0	None	N	None
23502	68	G/E	rs755417099	0.3223	gnomAD-4.0.0	100	None	0.7991	0.7506	32.0	N	-1.018	0.04	0.036661	-1.024	0.4803	0.0873	0.421294858915	3.025	1.0	0.67	0.617086127331	0.951	0.693202733994	-5.4	0.417	0.819	0.002	None	None	4.77529E-06	0	0	0	8.32778E-05	None	0	0	4.77529E-06	0	0	0	None	N	None
23502	68	G/R	rs781343586	0.3223	gnomAD-2.1.1	100	None	0.885	0.8666	25.4	D	-0.317	0.01	0.059407	-0.36	0.3613	-0.2057	0.136034570782	3.21	1.0	0.665	0.559387959211	0.156	0.70325088501	-5.4	0.41	0.577	0.002	None	None	8.05E-06	0	0	0	0	None	6.54E-05	None	8.05E-06	0	0	0	None	N	None
23502	68	G/R	rs781343586	0.3223	gnomAD-4.0.0	100	None	0.885	0.8666	25.4	D	-0.317	0.01	0.059407	-0.36	0.3613	-0.2057	0.136034570782	3.21	1.0	0.665	0.559387959211	0.156	0.70325088501	-5.4	0.41	0.577	0.002	None	None	4.77529E-06	0	0	0	0	None	0	0	4.77529E-06	8.57765E-06	0	0	None	N	None
23503	69	C/G	rs778748283	0.2518	gnomAD-4.0.0	102	None	0.1357	0.146	None	N	-2.124	None	None	-2.007	None	None	None	None	None	None	None	0.059	None	None	0.231	0.399	None	None	None	2.28268E-03	3.55586E-03	1.13626E-02	1.91369E-04	8.00205E-03	None	1.54069E-03	0	2.28268E-03	1.12973E-03	1.23952E-03	1.03438E-03	None	N	None
23503	69	C/Y	rs1466729716	0.2518	gnomAD-2.1.1	102	None	0.226	0.2427	23.7	N	-1.243	0.44	0.037056	-1.067	0.1764	-0.7989	0.287938430721	2.455	0.994	0.567	0.577370020343	0.724	0.57744383812	-6.48	0.25	0.507	0.087	None	None	4.03E-06	0	0	0	0	None	3.27E-05	None	4.03E-06	0	0	0	None	N	None
23503	69	C/Y	rs1466729716	0.2518	gnomAD-4.0.0	102	None	0.226	0.2427	23.7	N	-1.243	0.44	0.037056	-1.067	0.1764	-0.7989	0.287938430721	2.455	0.994	0.567	0.577370020343	0.724	0.57744383812	-6.48	0.25	0.507	0.087	None	None	1.59172E-06	0	0	0	0	None	0	0	1.59172E-06	0	1.43303E-05	0	None	N	None
23504	70	E/D	None	0.4529	gnomAD-4.0.0	103	None	0.1413	0.1845	24.3	N	None	0.34	0.021302	-1.189	0.114	-1.0258	0.0764562275565	1.905	0.999329	0.576	0.240491677333	None	0.56402862072	-2.15	0.083	0.109	0.054	None	None	6.84291E-07	0	0	0	0	None	0	0	6.84291E-07	8.99557E-07	0	0	None	N	None
23504	70	E/Q	rs1362847983	0.4529	gnomAD-2.1.1	103	None	0.1869	0.1896	25.3	N	-0.858	0.36	0.014933	-1.195	0.1267	-0.9811	0.0841933520624	1.885	0.999978	0.642	0.275641507738	0.002	0.550539374352	-1.9	0.116	0.199	0.111	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	0	9.19118E-04	None	N	None
23504	70	E/Q	rs1362847983	0.4529	gnomAD-3.1.2	103	None	0.1869	0.1896	25.3	N	-0.858	0.36	0.014933	-1.195	0.1267	-0.9811	0.0841933520624	1.885	0.999978	0.642	0.275641507738	0.002	0.550539374352	-1.9	0.116	0.199	0.111	None	None	6.57E-06	0	6.55E-05	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
23504	70	E/Q	rs1362847983	0.4529	gnomAD-4.0.0	103	None	0.1869	0.1896	25.3	N	-0.858	0.36	0.014933	-1.195	0.1267	-0.9811	0.0841933520624	1.885	0.999978	0.642	0.275641507738	0.002	0.550539374352	-1.9	0.116	0.199	0.111	None	None	5.07505E-06	0	6.15612E-05	0	0	None	0	0	5.07505E-06	3.61491E-06	0	3.40298E-05	None	N	None
23505	71	Y/D	None	0.1089	gnomAD-4.0.0	104	None	0.9935	0.9941	29.2	D	None	-2.5	0.193115	-3.582	0.9154	1.0925	0.61613149071	4.69	1.0	0.914	0.895123102283	1.0	0.726894974709	-7.33	0.887	0.86	0.007	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23506	72	F/L	rs753350142	0.1620	gnomAD-2.1.1	105	None	0.8774	0.9041	25.0	N	-1.595	0.47	0.012047	-1.599	0.1134	-0.966	0.100186145795	0.49	0.877552	0.332	0.548654159409	0.001	0.697438657284	-3.87	0.294	0.275	0.025	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	N	None
23506	72	F/L	rs753350142	0.1620	gnomAD-4.0.0	105	None	0.8774	0.9041	25.0	N	-1.595	0.47	0.012047	-1.599	0.1134	-0.966	0.100186145795	0.49	0.877552	0.332	0.548654159409	0.001	0.697438657284	-3.87	0.294	0.275	0.025	None	None	1.59165E-06	0	0	0	0	None	0	0	1.59165E-06	2.85909E-06	0	0	None	N	None
23507	73	F/L	rs764286640	0.1332	gnomAD-2.1.1	106	None	0.988	0.9895	26.7	N	-1.427	0.23	0.043347	-1.47	0.4277	-0.1002	0.496690708363	3.15	0.999951	0.619	0.603876675548	1.0	0.7518440485	-4.4	0.535	0.695	None	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
23507	73	F/L	rs764286640	0.1332	gnomAD-4.0.0	106	None	0.988	0.9895	26.7	N	-1.427	0.23	0.043347	-1.47	0.4277	-0.1002	0.496690708363	3.15	0.999951	0.619	0.603876675548	1.0	0.7518440485	-4.4	0.535	0.695	None	None	None	3.18322E-06	0	0	0	0	None	0	0	3.18322E-06	0	2.86599E-05	0	None	N	None
23508	74	R/G	rs1709797711	0.2078	gnomAD-3.1.2	107	None	0.9797	0.9853	34.0	D	None	0.16	0.135315	-1.915	0.5206	0.2459	0.523692950483	4.675	0.999968	0.68	0.586816528483	1.0	0.634449541569	-5.13	0.609	0.748	0.003	None	None	6.57E-06	0	6.55E-05	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
23508	74	R/G	rs1709797711	0.2078	gnomAD-4.0.0	107	None	0.9797	0.9853	34.0	D	None	0.16	0.135315	-1.915	0.5206	0.2459	0.523692950483	4.675	0.999968	0.68	0.586816528483	1.0	0.634449541569	-5.13	0.609	0.748	0.003	None	None	6.57358E-06	0	6.54879E-05	0	0	None	0	0	6.57358E-06	0	0	0	None	N	None
23508	74	R/I	rs1414118885	0.2078	gnomAD-2.1.1	107	None	0.9718	0.9809	27.7	D	-0.476	0.16	0.094756	-0.514	0.5422	0.3122	0.615612516959	3.43	1.0	0.679	0.769923350388	1.0	0.662061870098	-5.87	0.608	0.826	0.001	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	N	None
23508	74	R/I	rs1414118885	0.2078	gnomAD-4.0.0	107	None	0.9718	0.9809	27.7	D	-0.476	0.16	0.094756	-0.514	0.5422	0.3122	0.615612516959	3.43	1.0	0.679	0.769923350388	1.0	0.662061870098	-5.87	0.608	0.826	0.001	None	None	2.73711E-06	0	0	0	0	None	0	0	2.73711E-06	3.59822E-06	0	0	None	N	None
23509	75	V/E	rs926271333	0.0942	gnomAD-4.0.0	108	None	0.9973	0.9978	33.0	D	None	-0.83	0.168548	-3.327	0.7656	0.8914	0.578397025268	4.625	1.0	0.868	0.905623151949	1.0	0.695601165295	-4.4	0.873	0.875	None	None	None	6.8427E-07	2.98846E-05	0	0	0	None	0	0	6.8427E-07	0	0	0	None	N	None
23509	75	V/G	rs926271333	0.0942	gnomAD-4.0.0	108	None	0.9657	0.9722	33.0	D	None	-0.83	0.128841	-3.08	0.7679	0.8947	0.523430700632	4.625	1.0	0.834	0.921624639312	1.0	0.614589810371	-5.13	0.864	0.891	None	None	None	6.8427E-07	0	0	0	0	None	0	0	6.8427E-07	8.99548E-07	0	0	None	N	None
23510	76	M/I	rs727503569	0.1200	gnomAD-3.1.2	109	None	0.5823	0.584	24.8	N	None	0.5	0.016562	-1.075	0.1098	-0.9339	0.106129610619	-0.515	0.91101	0.518	0.431150418975	0.048	0.504234015942	-2.1	0.123	0.463	0.197	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
23510	76	M/I	rs727503569	0.1200	gnomAD-4.0.0	109	None	0.5823	0.584	24.8	N	None	0.5	0.016562	-1.075	0.1098	-0.9339	0.106129610619	-0.515	0.91101	0.518	0.431150418975	0.048	0.504234015942	-2.1	0.123	0.463	0.197	None	None	3.71861E-06	0	0	0	0	None	0	0	3.71861E-06	5.08625E-06	0	0	None	N	None
23510	76	M/T	None	0.1200	gnomAD-4.0.0	109	None	0.196	0.1997	24.5	N	None	0.54	0.017399	-1.827	0.0827	-0.9866	0.0970579765109	0.28	0.68112	0.422	0.469333501611	0.001	0.590284585953	-3.05	0.269	0.381	0.701	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
23510	76	M/V	None	0.1200	gnomAD-4.0.0	109	None	0.1996	0.1859	22.7	N	None	0.53	0.011172	-1.442	0.0778	-1.019	0.0899913693432	0.155	0.96641	0.524	0.386558576397	0.022	0.443611592054	-2.18	0.184	0.447	0.188	None	None	1.36852E-06	0	0	0	0	None	0	0	1.36852E-06	1.79909E-06	0	0	None	N	None
23511	77	A/G	rs1709793052	0.1236	gnomAD-4.0.0	110	None	0.3384	0.3432	34.0	N	None	-0.38	0.055271	-2.103	0.5278	0.1019	0.462416850623	2.605	1.0	0.847	0.528561964389	1.0	0.653705835342	-2.93	0.642	0.609	0.015	None	None	5.4741E-06	0	0	0	0	None	0	0	5.4741E-06	7.19641E-06	0	0	None	N	None
23511	77	A/T	rs1423033072	0.1236	gnomAD-2.1.1	110	None	0.9067	0.9521	32.0	D	-1.82	-0.27	0.099581	-1.873	0.6525	0.5681	0.457598942377	3.445	1.0	0.815	0.550926910813	1.0	0.66704416275	-2.93	0.7	0.791	0.005	None	None	4.02E-06	0	0	0	5.57E-05	None	0	None	4.02E-06	0	0	0	None	N	None
23511	77	A/T	rs1423033072	0.1236	gnomAD-4.0.0	110	None	0.9067	0.9521	32.0	D	-1.82	-0.27	0.099581	-1.873	0.6525	0.5681	0.457598942377	3.445	1.0	0.815	0.550926910813	1.0	0.66704416275	-2.93	0.7	0.791	0.005	None	None	1.59158E-06	0	0	0	2.77377E-05	None	0	0	1.59158E-06	0	0	0	None	N	None
23512	78	E/D	None	0.2663	gnomAD-4.0.0	111	None	0.9006	0.9221	25.5	N	None	0.4	0.036891	-1.366	0.404	-0.2891	0.438787105072	3.72	0.999489	0.455	0.335910606209	0.974	0.660161018372	-2.2	0.342	0.459	0.05	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	6.07533E-05	0	None	I	None
23512	78	E/G	None	0.2663	gnomAD-4.0.0	111	None	0.7537	0.8233	34.0	N	None	0.4	0.064763	-0.941	0.4409	0.0757	0.501067798211	3.17	1.0	0.457	0.459906663326	1.0	0.627325057983	-5.13	0.585	0.765	0.014	None	None	1.59157E-06	0	0	0	0	None	0	0	1.59157E-06	2.85914E-06	0	0	None	I	None
23512	78	E/K	rs752696466	0.2663	gnomAD-2.1.1	111	None	0.5762	0.671	31.0	N	-0.669	0.44	0.032161	-0.536	0.3816	-0.254	0.490409126362	2.865	1.0	0.598	0.315609569513	0.998	0.730761885643	-2.93	0.388	0.538	0.022	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	I	None
23512	78	E/K	rs752696466	0.2663	gnomAD-4.0.0	111	None	0.5762	0.671	31.0	N	-0.669	0.44	0.032161	-0.536	0.3816	-0.254	0.490409126362	2.865	1.0	0.598	0.315609569513	0.998	0.730761885643	-2.93	0.388	0.538	0.022	None	None	1.59154E-06	0	0	0	0	None	0	0	1.59154E-06	0	1.43299E-05	0	None	I	None
23513	79	N/S	rs1553613561	0.0945	gnomAD-4.0.0	112	None	0.9815	0.9817	29.3	D	None	0.11	0.029223	-0.965	0.5161	0.2989	0.417388960371	3.68	1.0	0.651	0.38342384377	0.999	0.649348497391	-3.67	0.533	0.589	None	None	None	2.05278E-06	0	0	0	0	None	0	0	2.05278E-06	2.69865E-06	0	0	None	N	None
23514	80	E/K	None	0.3997	gnomAD-4.0.0	113	None	0.4494	0.5208	26.1	N	None	0.44	0.02874	0.302	0.1213	-0.9068	0.159137384698	1.17	1.0	0.595	0.218845423259	0.538	0.68270277977	-2.77	0.235	0.431	0.065	None	None	6.84261E-07	0	0	0	0	None	0	0	6.84261E-07	8.99549E-07	0	0	None	I	None
23515	81	Y/C	None	0.3226	gnomAD-4.0.0	114	None	0.4104	0.563	32.0	N	None	0.42	0.039288	0.112	0.2557	-0.5341	0.366881939327	1.8	0.999254	0.442	0.394837016283	0.952	0.609738111496	-5.73	0.304	0.467	0.002	None	None	8.89535E-06	0	0	0	0	None	0	0	8.89535E-06	1.16941E-05	0	0	None	I	None
23515	81	Y/D	None	0.3226	gnomAD-4.0.0	114	None	0.9258	0.9397	32.0	N	None	0.52	0.043555	0.981	0.3457	-0.0787	0.366224267869	3.53	0.999281	0.466	0.588141112584	0.952	0.602950572968	-6.53	0.359	0.494	0.001	None	None	1.59154E-06	5.65739E-05	0	0	0	None	0	0	1.59154E-06	0	0	0	None	I	None
23518	84	G/A	None	0.1507	gnomAD-4.0.0	118	None	0.8464	0.8733	28.0	D	None	-0.22	0.0966	-0.861	0.6987	0.7406	0.481701296431	4.475	1.0	0.777	0.454426139905	1.0	0.608055591583	-4.4	0.737	0.703	None	None	None	1.59154E-06	0	0	0	0	None	0	0	1.59154E-06	2.8591E-06	0	0	None	I	None
23519	85	E/K	rs1267057579	0.3948	gnomAD-2.1.1	119	None	0.2745	0.3644	24.5	N	0.57	0.39	0.042124	0.211	0.2173	-0.6347	0.294285333989	1.85	0.999991	0.526	0.371344866733	0.822	0.54663670063	-2.9	0.245	0.637	0.059	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	I	None
23519	85	E/K	rs1267057579	0.3948	gnomAD-4.0.0	119	None	0.2745	0.3644	24.5	N	0.57	0.39	0.042124	0.211	0.2173	-0.6347	0.294285333989	1.85	0.999991	0.526	0.371344866733	0.822	0.54663670063	-2.9	0.245	0.637	0.059	None	None	2.05277E-06	0	0	0	2.51978E-05	None	0	0	2.05277E-06	1.7991E-06	0	0	None	I	None
23520	86	P/L	rs763169614	0.4608	gnomAD-2.1.1	120	None	0.4417	0.5549	35.0	D	-0.755	0.47	0.037658	-0.634	0.4547	0.2225	0.402729145482	3.73	1.0	0.493	0.615473259424	0.997	0.619367897511	-6.67	0.418	0.762	0.003	None	None	1.21E-05	0	0	0	0	None	0	None	1.21E-05	0	2.67E-05	0	None	I	None
23520	86	P/L	rs763169614	0.4608	gnomAD-4.0.0	120	None	0.4417	0.5549	35.0	D	-0.755	0.47	0.037658	-0.634	0.4547	0.2225	0.402729145482	3.73	1.0	0.493	0.615473259424	0.997	0.619367897511	-6.67	0.418	0.762	0.003	None	None	1.98434E-05	0	0	0	0	None	0	0	1.98434E-05	2.60869E-05	0	0	None	I	None
23520	86	P/R	rs763169614	0.4608	gnomAD-2.1.1	120	None	0.7757	0.8579	35.0	D	-0.306	0.42	0.01773	-0.247	0.4769	0.2596	0.467918965793	4.42	0.999897	0.445	0.486779940545	1.0	0.612290918827	-6.0	0.458	0.845	0.002	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	I	None
23520	86	P/R	rs763169614	0.4608	gnomAD-3.1.2	120	None	0.7757	0.8579	35.0	D	-0.306	0.42	0.01773	-0.247	0.4769	0.2596	0.467918965793	4.42	0.999897	0.445	0.486779940545	1.0	0.612290918827	-6.0	0.458	0.845	0.002	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	I	None
23520	86	P/R	rs763169614	0.4608	gnomAD-4.0.0	120	None	0.7757	0.8579	35.0	D	-0.306	0.42	0.01773	-0.247	0.4769	0.2596	0.467918965793	4.42	0.999897	0.445	0.486779940545	1.0	0.612290918827	-6.0	0.458	0.845	0.002	None	None	6.57912E-06	0	0	0	0	None	0	0	6.57912E-06	1.47089E-05	0	0	None	I	None
23520	86	P/T	rs1296805014	0.4608	gnomAD-2.1.1	120	None	0.3871	0.4563	28.1	N	-1.036	0.41	0.014359	-0.877	0.437	0.1439	0.425096815783	3.38	0.999751	0.393	0.39843156188	0.993	0.592656075954	-5.27	0.335	0.795	0.005	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	I	None
23520	86	P/T	rs1296805014	0.4608	gnomAD-3.1.2	120	None	0.3871	0.4563	28.1	N	-1.036	0.41	0.014359	-0.877	0.437	0.1439	0.425096815783	3.38	0.999751	0.393	0.39843156188	0.993	0.592656075954	-5.27	0.335	0.795	0.005	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	I	None
23520	86	P/T	rs1296805014	0.4608	gnomAD-4.0.0	120	None	0.3871	0.4563	28.1	N	-1.036	0.41	0.014359	-0.877	0.437	0.1439	0.425096815783	3.38	0.999751	0.393	0.39843156188	0.993	0.592656075954	-5.27	0.335	0.795	0.005	None	None	6.57756E-06	0	0	0	0	None	0	0	6.57756E-06	1.47076E-05	0	0	None	I	None
23521	87	T/I	rs775589244	0.2440	gnomAD-2.1.1	121	None	0.1066	0.1259	23.1	N	-0.005	0.59	0.023694	0.015	0.1624	-0.8521	0.0926214090609	0.935	0.80201	0.515	0.17258766438	0.012	0.253032714128	-2.62	0.125	0.467	0.058	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	I	None
23521	87	T/I	rs775589244	0.2440	gnomAD-4.0.0	121	None	0.1066	0.1259	23.1	N	-0.005	0.59	0.023694	0.015	0.1624	-0.8521	0.0926214090609	0.935	0.80201	0.515	0.17258766438	0.012	0.253032714128	-2.62	0.125	0.467	0.058	None	None	6.84256E-07	0	2.23604E-05	0	0	None	0	0	6.84256E-07	0	0	0	None	I	None
23521	87	T/P	rs1007385866	0.2440	gnomAD-3.1.2	121	None	0.7055	0.7529	15.7	N	None	0.58	0.025794	-0.231	0.1211	-0.8306	0.124478146582	1.63	0.999964	0.536	0.0297737177859	0.055	0.233691751957	-2.87	0.108	0.501	0.045	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
23521	87	T/P	rs1007385866	0.2440	gnomAD-4.0.0	121	None	0.7055	0.7529	15.7	N	None	0.58	0.025794	-0.231	0.1211	-0.8306	0.124478146582	1.63	0.999964	0.536	0.0297737177859	0.055	0.233691751957	-2.87	0.108	0.501	0.045	None	None	6.5735E-06	0	0	0	0	None	0	0	6.5735E-06	1.47067E-05	0	0	None	I	None
23521	87	T/R	rs775589244	0.2440	gnomAD-2.1.1	121	None	0.1673	0.1879	None	N	-0.644	None	None	-0.736	None	None	None	None	None	None	None	None	None	None	0.118	0.4	None	None	None	3.22E-05	0	5.79E-05	0	0	None	0	None	3.22E-05	0	5.34E-05	0	None	I	None
23521	87	T/R	rs775589244	0.2440	gnomAD-3.1.2	121	None	0.1673	0.1879	None	N	-0.644	None	None	-0.736	None	None	None	None	None	None	None	None	None	None	0.118	0.4	None	None	None	1.32E-05	0	6.55E-05	0	0	None	0	0	1.32E-05	1.47E-05	0	0	None	I	None
23521	87	T/R	rs775589244	0.2440	gnomAD-4.0.0	121	None	0.1673	0.1879	None	N	-0.644	None	None	-0.736	None	None	None	None	None	None	None	None	None	None	0.118	0.4	None	None	None	1.73537E-05	0	3.33456E-05	0	0	None	0	1.64582E-04	1.73537E-05	1.78017E-05	0	6.40492E-05	None	I	None
23522	88	E/K	rs561586925	0.2700	gnomAD-2.1.1	122	None	0.4349	0.5498	27.2	N	-0.34	0.5	0.030724	-0.385	0.3658	-0.3022	0.48109839602	2.33	1.0	0.336	0.476908202251	0.995	0.674438178539	-2.93	0.302	0.805	0.01	None	None	2.41E-05	0	8.69E-05	0	0	None	0	None	2.41E-05	0	8.9E-06	3.31895E-04	None	N	None
23522	88	E/K	rs561586925	0.2700	gnomAD-3.1.2	122	None	0.4349	0.5498	27.2	N	-0.34	0.5	0.030724	-0.385	0.3658	-0.3022	0.48109839602	2.33	1.0	0.336	0.476908202251	0.995	0.674438178539	-2.93	0.302	0.805	0.01	None	None	1.97E-05	0	1.96515E-04	0	0	None	0	0	1.97E-05	0	0	0	None	N	None
23522	88	E/K	rs561586925	0.2700	1000 genomes	122	None	0.4349	0.5498	27.2	N	-0.34	0.5	0.030724	-0.385	0.3658	-0.3022	0.48109839602	2.33	1.0	0.336	0.476908202251	0.995	0.674438178539	-2.93	0.302	0.805	0.01	None	None	1.99681E-04	0	1.4E-03	None	0	0	None	None	1.99681E-04	None	0	None	None	N	None
23522	88	E/K	rs561586925	0.2700	gnomAD-4.0.0	122	None	0.4349	0.5498	27.2	N	-0.34	0.5	0.030724	-0.385	0.3658	-0.3022	0.48109839602	2.33	1.0	0.336	0.476908202251	0.995	0.674438178539	-2.93	0.302	0.805	0.01	None	None	7.43646E-06	0	8.33222E-05	0	0	None	0	0	7.43646E-06	4.2385E-06	0	3.20123E-05	None	N	None
23524	90	T/A	rs369526268	0.8534	gnomAD-2.1.1	124	None	0.0559	0.0563	None	N	0.078	None	None	-0.142	None	None	None	None	None	None	None	None	None	None	0.093	0.038	None	None	None	2.82E-05	0	0	0	0	None	0	None	2.82E-05	0	6.23E-05	0	None	N	None
23524	90	T/A	rs369526268	0.8534	gnomAD-3.1.2	124	None	0.0559	0.0563	None	N	0.078	None	None	-0.142	None	None	None	None	None	None	None	None	None	None	0.093	0.038	None	None	None	4.6E-05	0	0	0	0	None	0	0	4.6E-05	1.02938E-04	0	0	None	N	None
23524	90	T/A	rs369526268	0.8534	gnomAD-4.0.0	124	None	0.0559	0.0563	None	N	0.078	None	None	-0.142	None	None	None	None	None	None	None	None	None	None	0.093	0.038	None	None	None	5.57772E-05	0	0	0	0	None	1.56187E-05	0	5.57772E-05	7.29019E-05	0	4.80338E-05	None	N	None
23524	90	T/K	rs748544908	0.8534	gnomAD-2.1.1	124	None	0.1172	0.128	24.5	N	0.083	0.55	0.023183	-0.317	0.1088	-0.9802	0.100938685441	1.015	0.937132	0.36	0.201204373187	None	0.401166915894	-3.04	0.087	0.111	0.273	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
23524	90	T/K	rs748544908	0.8534	gnomAD-4.0.0	124	None	0.1172	0.128	24.5	N	0.083	0.55	0.023183	-0.317	0.1088	-0.9802	0.100938685441	1.015	0.937132	0.36	0.201204373187	None	0.401166915894	-3.04	0.087	0.111	0.273	None	None	6.84257E-07	0	0	0	0	None	0	0	6.84257E-07	0	1.1595E-05	0	None	N	None
23524	90	T/R	None	0.8534	gnomAD-4.0.0	124	None	0.1154	0.1308	24.4	N	None	0.55	0.036112	-0.012	0.1508	-0.8615	0.0964821192323	1.615	0.957175	0.268	0.358134431457	0.112	0.394132018089	-3.17	0.069	0.421	0.164	None	None	6.84257E-07	0	0	0	0	None	0	0	6.84257E-07	0	1.1595E-05	0	None	N	None
23525	91	E/G	rs1709774465	0.5547	gnomAD-4.0.0	125	None	0.1747	0.2042	27.7	N	None	0.56	0.070743	-0.303	0.1711	-0.6864	0.119409164691	1.925	0.999981	0.28	0.391775403332	0.521	0.439736247063	-4.43	0.334	0.522	0.008	None	None	1.59151E-06	0	0	0	0	None	0	0	1.59151E-06	2.85914E-06	0	0	None	N	None
23527	93	V/I	rs542004766	0.2273	gnomAD-2.1.1	127	None	0.0711	0.0705	None	N	-0.358	None	None	-0.555	None	None	None	None	None	None	None	None	None	None	0.047	0.123	None	None	None	4.64E-05	1.65358E-04	5.65E-05	0	0	None	3.27E-05	None	4.64E-05	0	4.7E-05	0	None	N	None
23527	93	V/I	rs542004766	0.2273	gnomAD-3.1.2	127	None	0.0711	0.0705	None	N	-0.358	None	None	-0.555	None	None	None	None	None	None	None	None	None	None	0.047	0.123	None	None	None	5.92E-05	9.65E-05	1.31044E-04	0	0	None	0	0	5.92E-05	4.41E-05	0	0	None	N	None
23527	93	V/I	rs542004766	0.2273	1000 genomes	127	None	0.0711	0.0705	None	N	-0.358	None	None	-0.555	None	None	None	None	None	None	None	None	None	None	0.047	0.123	None	None	None	1.99681E-04	8E-04	0	None	0	0	None	None	1.99681E-04	None	0	None	None	N	None
23527	93	V/I	rs542004766	0.2273	gnomAD-4.0.0	127	None	0.0711	0.0705	None	N	-0.358	None	None	-0.555	None	None	None	None	None	None	None	None	None	None	0.047	0.123	None	None	None	2.60283E-05	9.3301E-05	6.66622E-05	0	0	None	0	0	2.60283E-05	1.86498E-05	5.49028E-05	6.40266E-05	None	N	None
23527	93	V/L	rs542004766	0.2273	gnomAD-2.1.1	127	None	0.2428	0.2226	22.7	N	-0.361	0.64	0.02957	-0.555	0.1186	-0.8571	0.0824739998354	1.89	0.522027	0.249	0.317378411342	None	0.428290069103	-1.83	0.053	0.219	0.023	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	N	None
23527	93	V/L	rs542004766	0.2273	gnomAD-3.1.2	127	None	0.2428	0.2226	22.7	N	-0.361	0.64	0.02957	-0.555	0.1186	-0.8571	0.0824739998354	1.89	0.522027	0.249	0.317378411342	None	0.428290069103	-1.83	0.053	0.219	0.023	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
23527	93	V/L	rs542004766	0.2273	gnomAD-4.0.0	127	None	0.2428	0.2226	22.7	N	-0.361	0.64	0.02957	-0.555	0.1186	-0.8571	0.0824739998354	1.89	0.522027	0.249	0.317378411342	None	0.428290069103	-1.83	0.053	0.219	0.023	None	None	2.47907E-06	0	0	0	0	None	0	0	2.47907E-06	3.39084E-06	0	0	None	N	None
23528	94	K/N	None	0.4352	gnomAD-4.0.0	129	None	0.772	0.8139	23.9	N	None	0.61	0.026151	0.134	0.1386	-0.9107	0.124547901559	2.295	0.912606	0.323	0.117506650769	0.163	0.347763538361	-2.1	0.1	0.628	0.064	None	None	1.59151E-06	0	0	0	0	None	0	0	1.59151E-06	2.85907E-06	0	0	None	N	None
23529	95	A/V	rs1709769243	0.0951	gnomAD-4.0.0	130	None	0.1265	0.1278	25.6	N	None	0.58	0.039403	-0.659	0.1016	-0.8929	0.0953196460905	0.835	0.999992	0.261	0.320256813643	0.977	0.525214552879	-2.6	0.196	0.359	0.277	None	None	2.73701E-06	0	0	0	0	None	0	0	2.73701E-06	2.69866E-06	0	1.65662E-05	None	N	None
23531	97	E/K	rs1182129747	0.6122	gnomAD-3.1.2	132	None	0.3875	0.4954	24.1	N	None	0.54	0.062702	0.581	0.2708	-0.3155	0.165598894335	3.09	0.999899	0.332	0.359357374593	0.872	0.573953866959	-2.5	0.28	0.616	0.008	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
23531	97	E/K	rs1182129747	0.6122	gnomAD-4.0.0	132	None	0.3875	0.4954	24.1	N	None	0.54	0.062702	0.581	0.2708	-0.3155	0.165598894335	3.09	0.999899	0.332	0.359357374593	0.872	0.573953866959	-2.5	0.28	0.616	0.008	None	None	2.03004E-06	0	0	0	0	None	0	0	2.03004E-06	1.20497E-06	4.69836E-05	0	None	N	None

Whole Population MAF	African (AFR)	Latin American (AMR)
Amish (AMS)	Ashkenazi Jewish (ASJ)	East Asian (EAS)
European/1KGP (EUR)	Finnish (FIN)	Middle Eastern (MDE)
Non-Finnish European (NFE)	South Asian (SAS)	Other (OTH)

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