10 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A | N | M | A | R | E | Q | H | I | K | V | G | D | T | L | R | L | S | A | I | I | K | G | V | P | F | P | K | V | T | W | K | K | E | D | R | D | A | P | T | K | A | R | I | D | V | T | P | V | G | S | K | L | E | I | R | N | A | A | H | E | D | G | G | I | Y | S | L | T | V | E | N | P | A | G | S | K | T | V | S | V | K | V | L | V |
Pin SAV |
Position |
Domain position |
SAV |
Structural Position |
RS |
Q(SASA) |
Disease |
Source |
MAF |
---|---|---|---|---|---|---|---|---|---|
19790 | 1 | A/D | 1 | None | 0.9438 | None | gnomAD-4.0.0 | 6.8448E-07 | |
19790 | 1 | A/V | 1 | rs1410710532 | 0.9438 | None | gnomAD-2.1.1 | 8.08E-06 | |
19790 | 1 | A/V | 1 | rs1410710532 | 0.9438 | None | gnomAD-3.1.2 | 6.58E-06 | |
19790 | 1 | A/V | 1 | rs1410710532 | 0.9438 | None | gnomAD-4.0.0 | 1.8599E-06 | |
19791 | 2 | N/I | 2 | rs2050467493 | 0.2864 | None | gnomAD-4.0.0 | 1.36889E-06 | |
19792 | 3 | M/V | 3 | None | 0.2134 | None | gnomAD-4.0.0 | 1.59254E-06 | |
19793 | 4 | A/V | 4 | rs1433039414 | 0.3244 | None | gnomAD-2.1.1 | 3.19E-05 | |
19793 | 4 | A/V | 4 | rs1433039414 | 0.3244 | None | gnomAD-3.1.2 | 1.32E-05 | |
19793 | 4 | A/V | 4 | rs1433039414 | 0.3244 | None | gnomAD-4.0.0 | 5.12832E-06 | |
19795 | 6 | E/G | 11 | rs776032119 | 0.4777 | None | gnomAD-2.1.1 | 7.16E-06 | |
19795 | 6 | E/G | 11 | rs776032119 | 0.4777 | None | gnomAD-3.1.2 | 6.57E-06 | |
19795 | 6 | E/G | 11 | rs776032119 | 0.4777 | None | gnomAD-4.0.0 | 2.56374E-06 | |
19795 | 6 | E/K | 11 | None | 0.4777 | None | gnomAD-4.0.0 | 1.59241E-06 | |
19797 | 8 | H/Y | 14 | rs2050464910 | 0.7202 | None | gnomAD-3.1.2 | 6.58E-06 | |
19797 | 8 | H/Y | 14 | rs2050464910 | 0.7202 | None | gnomAD-4.0.0 | 6.57592E-06 | |
19798 | 9 | I/M | 16 | rs772501285 | 0.1524 | None | gnomAD-2.1.1 | 4.03E-06 | |
19798 | 9 | I/M | 16 | rs772501285 | 0.1524 | None | gnomAD-4.0.0 | 1.59211E-06 | |
19798 | 9 | I/N | 16 | None | 0.1524 | None | gnomAD-4.0.0 | 1.59213E-06 | |
19798 | 9 | I/T | 16 | None | 0.1524 | None | gnomAD-4.0.0 | 1.59213E-06 | |
19799 | 10 | K/N | 18 | rs570087924 | 0.6665 | None | gnomAD-2.1.1 | 4.03E-06 | |
19799 | 10 | K/N | 18 | rs570087924 | 0.6665 | None | gnomAD-3.1.2 | 6.57E-06 | |
19799 | 10 | K/N | 18 | rs570087924 | 0.6665 | None | 1000 genomes | 1.99681E-04 | |
19799 | 10 | K/N | 18 | rs570087924 | 0.6665 | None | gnomAD-4.0.0 | 6.56935E-06 | |
19799 | 10 | K/R | 18 | None | 0.6665 | None | gnomAD-4.0.0 | 1.59208E-06 | |
19800 | 11 | V/A | 23 | rs747359962 | 0.4912 | None | gnomAD-4.0.0 | 1.02654E-05 | |
19801 | 12 | G/D | 24 | rs202206216 | 0.2761 | None | gnomAD-2.1.1 | 1.68147E-04 | |
19801 | 12 | G/D | 24 | rs202206216 | 0.2761 | None | gnomAD-3.1.2 | 1.31517E-04 | |
19801 | 12 | G/D | 24 | rs202206216 | 0.2761 | None | gnomAD-4.0.0 | 1.30167E-04 | |
19801 | 12 | G/V | 24 | None | 0.2761 | None | gnomAD-4.0.0 | 6.8435E-07 | |
19802 | 13 | D/A | 25 | rs747743986 | 0.4363 | None | gnomAD-2.1.1 | 1.61E-05 | |
19802 | 13 | D/A | 25 | rs747743986 | 0.4363 | None | gnomAD-3.1.2 | 6.57E-06 | |
19802 | 13 | D/A | 25 | rs747743986 | 0.4363 | None | gnomAD-4.0.0 | 4.95857E-06 | |
19802 | 13 | D/N | 25 | rs771426226 | 0.4363 | None | gnomAD-2.1.1 | 4.03E-06 | |
19802 | 13 | D/N | 25 | rs771426226 | 0.4363 | None | gnomAD-4.0.0 | 1.59202E-06 | |
19804 | 15 | L/R | 28 | None | 0.1759 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19807 | 18 | S/R | 31 | None | 0.3601 | None | gnomAD-4.0.0 | 6.84331E-07 | |
19808 | 19 | A/V | 33 | rs780766254 | 0.3232 | None | gnomAD-2.1.1 | 8.05E-06 | |
19808 | 19 | A/V | 33 | rs780766254 | 0.3232 | None | gnomAD-4.0.0 | 4.106E-06 | |
19809 | 20 | I/V | 34 | rs754507241 | 0.8321 | None | gnomAD-2.1.1 | 8.05E-06 | |
19809 | 20 | I/V | 34 | rs754507241 | 0.8321 | None | gnomAD-4.0.0 | 1.59192E-06 | |
19810 | 21 | I/S | 35 | None | 0.1623 | None | gnomAD-4.0.0 | 1.59192E-06 | |
19810 | 21 | I/V | 35 | None | 0.1623 | None | gnomAD-4.0.0 | 2.40064E-06 | |
19812 | 23 | G/A | 40 | None | 0.3391 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19812 | 23 | G/R | 40 | None | 0.3391 | None | gnomAD-4.0.0 | 7.52761E-06 | |
19814 | 25 | P/S | 42 | None | 0.4764 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19815 | 26 | F/L | 43 | None | 0.3618 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19816 | 27 | P/L | 44 | rs2050451643 | 0.1312 | None | gnomAD-4.0.0 | 1.59184E-06 | |
19818 | 29 | V/G | 46 | rs1371676567 | 0.2688 | None | gnomAD-2.1.1 | 4.02E-06 | |
19819 | 30 | T/I | 47 | rs758287054 | 0.4307 | None | gnomAD-2.1.1 | 1.43E-05 | |
19819 | 30 | T/I | 47 | rs758287054 | 0.4307 | None | gnomAD-3.1.2 | 3.95E-05 | |
19819 | 30 | T/I | 47 | rs758287054 | 0.4307 | None | gnomAD-4.0.0 | 4.95871E-06 | |
19819 | 30 | T/S | 47 | rs758287054 | 0.4307 | None | gnomAD-2.1.1 | 4.02E-06 | |
19819 | 30 | T/S | 47 | rs758287054 | 0.4307 | None | gnomAD-4.0.0 | 6.84318E-07 | |
19820 | 31 | W/G | 48 | None | 0.1982 | None | gnomAD-4.0.0 | 4.80129E-06 | |
19822 | 33 | K/E | 50 | None | 0.1361 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19823 | 34 | E/G | 51 | None | 0.4138 | None | gnomAD-4.0.0 | 1.59182E-06 | |
19823 | 34 | E/K | 51 | None | 0.4138 | None | gnomAD-4.0.0 | 1.59184E-06 | |
19825 | 36 | R/T | 55 | rs376465623 | 0.7936 | None | gnomAD-2.1.1 | 6.08E-05 | |
19825 | 36 | R/T | 55 | rs376465623 | 0.7936 | None | gnomAD-3.1.2 | 5.26E-05 | |
19825 | 36 | R/T | 55 | rs376465623 | 0.7936 | None | gnomAD-4.0.0 | 1.02269E-04 | |
19827 | 38 | A/P | 58 | None | 0.2662 | None | gnomAD-4.0.0 | 1.59184E-06 | |
19827 | 38 | A/T | 58 | rs1486455831 | 0.2662 | None | gnomAD-2.1.1 | 3.19E-05 | |
19827 | 38 | A/T | 58 | rs1486455831 | 0.2662 | None | gnomAD-3.1.2 | 6.58E-06 | |
19827 | 38 | A/T | 58 | rs1486455831 | 0.2662 | None | gnomAD-4.0.0 | 6.57791E-06 | |
19827 | 38 | A/V | 58 | None | 0.2662 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19828 | 39 | P/S | 59 | None | 0.2778 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19829 | 40 | T/A | 70 | rs1436610603 | 1.0115 | None | gnomAD-2.1.1 | 4.03E-06 | |
19829 | 40 | T/A | 70 | rs1436610603 | 1.0115 | None | gnomAD-4.0.0 | 1.36864E-06 | |
19829 | 40 | T/I | 70 | rs754082474 | 1.0115 | None | gnomAD-2.1.1 | 4.03E-06 | |
19829 | 40 | T/I | 70 | rs754082474 | 1.0115 | None | gnomAD-4.0.0 | 3.18372E-06 | |
19829 | 40 | T/S | 70 | rs754082474 | 1.0115 | None | gnomAD-2.1.1 | 4.03E-06 | |
19829 | 40 | T/S | 70 | rs754082474 | 1.0115 | None | gnomAD-3.1.2 | 6.58E-06 | |
19829 | 40 | T/S | 70 | rs754082474 | 1.0115 | None | gnomAD-4.0.0 | 6.57687E-06 | |
19830 | 41 | K/R | 73 | rs764259290 | 0.3923 | None | gnomAD-2.1.1 | 1.79E-05 | |
19830 | 41 | K/R | 73 | rs764259290 | 0.3923 | None | gnomAD-3.1.2 | 9.86E-05 | |
19830 | 41 | K/R | 73 | rs764259290 | 0.3923 | None | gnomAD-4.0.0 | 2.3068E-05 | |
19831 | 42 | A/V | 109 | rs760784061 | 0.1764 | None | gnomAD-2.1.1 | 8.05E-06 | |
19831 | 42 | A/V | 109 | rs760784061 | 0.1764 | None | gnomAD-4.0.0 | 4.77553E-06 | |
19832 | 43 | R/I | 115 | rs1405596883 | 0.6419 | None | gnomAD-4.0.0 | 3.18366E-06 | |
19832 | 43 | R/K | 115 | rs1405596883 | 0.6419 | None | gnomAD-2.1.1 | 4.03E-06 | |
19832 | 43 | R/K | 115 | rs1405596883 | 0.6419 | None | gnomAD-4.0.0 | 1.59183E-06 | |
19833 | 44 | I/L | 121 | rs2050442222 | 0.3092 | None | gnomAD-3.1.2 | 6.57E-06 | |
19833 | 44 | I/L | 121 | rs2050442222 | 0.3092 | None | gnomAD-4.0.0 | 2.56307E-05 | |
19833 | 44 | I/S | 121 | None | 0.3092 | None | gnomAD-4.0.0 | 1.20032E-06 | |
19835 | 46 | V/G | 123 | rs727504511 | 0.4605 | None | gnomAD-2.1.1 | 6.44E-05 | |
19835 | 46 | V/G | 123 | rs727504511 | 0.4605 | None | gnomAD-3.1.2 | 3.29E-05 | |
19835 | 46 | V/G | 123 | rs727504511 | 0.4605 | None | gnomAD-4.0.0 | 4.58652E-05 | |
19838 | 49 | V/A | 134 | None | 0.6374 | None | gnomAD-4.0.0 | 3.60097E-06 | |
19838 | 49 | V/F | 134 | rs767665016 | 0.6374 | None | gnomAD-2.1.1 | 4.03E-06 | |
19838 | 49 | V/F | 134 | rs767665016 | 0.6374 | None | gnomAD-4.0.0 | 6.84322E-07 | |
19838 | 49 | V/L | 134 | rs767665016 | 0.6374 | None | gnomAD-2.1.1 | 4.03E-06 | |
19838 | 49 | V/L | 134 | rs767665016 | 0.6374 | None | gnomAD-4.0.0 | 4.10593E-06 | |
19839 | 50 | G/D | 135 | rs1256321814 | 0.1198 | None | gnomAD-2.1.1 | 4.03E-06 | |
19839 | 50 | G/D | 135 | rs1256321814 | 0.1198 | None | gnomAD-4.0.0 | 2.05296E-06 | |
19843 | 54 | E/K | 139 | rs1185186867 | 0.2267 | None | gnomAD-2.1.1 | 4.03E-06 | |
19843 | 54 | E/K | 139 | rs1185186867 | 0.2267 | None | gnomAD-4.0.0 | 5.47452E-06 | |
19845 | 56 | R/C | 141 | rs1232069163 | 0.6899 | None | gnomAD-2.1.1 | 3.19E-05 | |
19845 | 56 | R/C | 141 | rs1232069163 | 0.6899 | None | gnomAD-3.1.2 | 6.58E-06 | |
19845 | 56 | R/C | 141 | rs1232069163 | 0.6899 | None | gnomAD-4.0.0 | 4.95855E-06 | |
19845 | 56 | R/H | 141 | rs201457934 | 0.6899 | None | gnomAD-2.1.1 | 1.04721E-04 | |
19845 | 56 | R/H | 141 | rs201457934 | 0.6899 | None | gnomAD-3.1.2 | 2.63E-05 | |
19845 | 56 | R/H | 141 | rs201457934 | 0.6899 | None | gnomAD-4.0.0 | 4.46261E-05 | |
19845 | 56 | R/L | 141 | rs201457934 | 0.6899 | None | gnomAD-2.1.1 | 1.21E-05 | |
19845 | 56 | R/L | 141 | rs201457934 | 0.6899 | None | gnomAD-4.0.0 | 2.73727E-06 | |
19846 | 57 | N/H | 143 | rs749738999 | 0.7502 | None | gnomAD-2.1.1 | 4.03E-06 | |
19846 | 57 | N/H | 143 | rs749738999 | 0.7502 | None | gnomAD-4.0.0 | 3.18366E-06 | |
19848 | 59 | A/D | 145 | None | 0.2330 | None | gnomAD-4.0.0 | 6.84324E-07 | |
19848 | 59 | A/V | 145 | rs776318202 | 0.2330 | None | gnomAD-2.1.1 | 4.03E-06 | |
19848 | 59 | A/V | 145 | rs776318202 | 0.2330 | None | gnomAD-4.0.0 | 6.84324E-07 | |
19849 | 60 | H/Q | 146 | None | 0.8780 | None | gnomAD-4.0.0 | 1.5919E-06 | |
19852 | 63 | G/S | 151 | rs746700153 | 0.2123 | None | gnomAD-2.1.1 | 4.03E-06 | |
19852 | 63 | G/S | 151 | rs746700153 | 0.2123 | None | gnomAD-4.0.0 | 2.05299E-06 | |
19853 | 64 | G/R | 152 | None | 0.1631 | None | gnomAD-4.0.0 | 1.59196E-06 | |
19854 | 65 | I/T | 153 | rs1291718498 | 0.4406 | None | gnomAD-2.1.1 | 4.03E-06 | |
19855 | 66 | Y/N | 154 | rs779395388 | 0.1316 | None | gnomAD-2.1.1 | 4.03E-06 | |
19855 | 66 | Y/N | 154 | rs779395388 | 0.1316 | None | gnomAD-4.0.0 | 6.36787E-06 | |
19856 | 67 | S/F | 155 | None | 0.2143 | None | gnomAD-4.0.0 | 1.59196E-06 | |
19856 | 67 | S/Y | 155 | rs1356252369 | 0.2143 | None | gnomAD-2.1.1 | 4.03E-06 | |
19856 | 67 | S/Y | 155 | rs1356252369 | 0.2143 | None | gnomAD-4.0.0 | 1.59196E-06 | |
19857 | 68 | L/S | 156 | rs547180437 | 0.1343 | None | gnomAD-3.1.2 | 6.57E-06 | |
19857 | 68 | L/S | 156 | rs547180437 | 0.1343 | None | 1000 genomes | 1.99681E-04 | |
19857 | 68 | L/S | 156 | rs547180437 | 0.1343 | None | gnomAD-4.0.0 | 1.54942E-05 | |
19858 | 69 | T/I | 157 | rs757911359 | 0.2461 | None | gnomAD-2.1.1 | 7.66E-05 | |
19858 | 69 | T/I | 157 | rs757911359 | 0.2461 | None | gnomAD-3.1.2 | 1.32E-05 | |
19858 | 69 | T/I | 157 | rs757911359 | 0.2461 | None | gnomAD-4.0.0 | 4.27689E-05 | |
19858 | 69 | T/K | 157 | None | 0.2461 | None | gnomAD-4.0.0 | 6.84349E-07 | |
19858 | 69 | T/R | 157 | rs757911359 | 0.2461 | None | gnomAD-3.1.2 | 6.58E-06 | |
19858 | 69 | T/R | 157 | rs757911359 | 0.2461 | None | gnomAD-4.0.0 | 1.85952E-06 | |
19859 | 70 | V/M | 158 | rs778885421 | 0.2184 | None | gnomAD-2.1.1 | 1.21E-05 | |
19859 | 70 | V/M | 158 | rs778885421 | 0.2184 | None | gnomAD-4.0.0 | 3.42179E-06 | |
19860 | 71 | E/D | 159 | rs757011726 | 0.4083 | None | gnomAD-2.1.1 | 4.03E-06 | |
19860 | 71 | E/D | 159 | rs757011726 | 0.4083 | None | gnomAD-3.1.2 | 6.57E-06 | |
19860 | 71 | E/D | 159 | rs757011726 | 0.4083 | None | gnomAD-4.0.0 | 6.57488E-06 | |
19860 | 71 | E/K | 159 | None | 0.4083 | None | gnomAD-4.0.0 | 2.73746E-06 | |
19861 | 72 | N/S | 161 | None | 0.2083 | None | gnomAD-4.0.0 | 1.59214E-06 | |
19862 | 73 | P/L | 162 | rs16866406 | 0.7594 | None | gnomAD-2.1.1 | 1.7341E-01 | |
19862 | 73 | P/L | 162 | rs16866406 | 0.7594 | None | gnomAD-3.1.2 | 1.42446E-01 | |
19862 | 73 | P/L | 162 | rs16866406 | 0.7594 | None | 1000 genomes | 2.13059E-01 | |
19862 | 73 | P/L | 162 | rs16866406 | 0.7594 | None | gnomAD-4.0.0 | 1.53377E-01 | |
19863 | 74 | A/D | 163 | rs1416865059 | 0.7362 | None | gnomAD-2.1.1 | 4.03E-06 | |
19863 | 74 | A/D | 163 | rs1416865059 | 0.7362 | None | gnomAD-4.0.0 | 1.59233E-06 | |
19864 | 75 | G/D | 164 | rs763969580 | 0.3811 | None | gnomAD-2.1.1 | 8.07E-06 | |
19864 | 75 | G/D | 164 | rs763969580 | 0.3811 | None | gnomAD-3.1.2 | 1.32E-05 | |
19864 | 75 | G/D | 164 | rs763969580 | 0.3811 | None | gnomAD-4.0.0 | 7.43885E-06 | |
19865 | 76 | S/L | 165 | None | 0.5587 | None | gnomAD-4.0.0 | 1.59307E-06 | |
19868 | 79 | V/I | 169 | None | 0.5105 | None | gnomAD-4.0.0 | 6.84559E-07 | |
19870 | 81 | V/G | 172 | None | 0.1081 | None | gnomAD-4.0.0 | 1.59326E-06 | |
19871 | 82 | K/E | 173 | rs1475978640 | 0.3468 | None | gnomAD-2.1.1 | 8.08E-06 | |
19871 | 82 | K/E | 173 | rs1475978640 | 0.3468 | None | gnomAD-3.1.2 | 6.57E-06 | |
19871 | 82 | K/E | 173 | rs1475978640 | 0.3468 | None | gnomAD-4.0.0 | 3.72028E-06 | |
19871 | 82 | K/T | 173 | rs756249207 | 0.3468 | None | gnomAD-2.1.1 | 8.08E-06 | |
19871 | 82 | K/T | 173 | rs756249207 | 0.3468 | None | gnomAD-4.0.0 | 3.18692E-06 | |
19873 | 84 | L/F | 175 | None | 0.3732 | None | gnomAD-4.0.0 | 6.84901E-07 | |
19873 | 84 | L/P | 175 | rs727503589 | 0.3732 | None | gnomAD-2.1.1 | 1.21E-05 | |
19873 | 84 | L/P | 175 | rs727503589 | 0.3732 | None | gnomAD-4.0.0 | 8.21947E-06 | |
19873 | 84 | L/V | 175 | rs1185370817 | 0.3732 | None | gnomAD-2.1.1 | 4.04E-06 | |
19873 | 84 | L/V | 175 | rs1185370817 | 0.3732 | None | gnomAD-4.0.0 | 6.84901E-07 | |
19874 | 85 | V/A | 177 | rs1339819720 | 0.1498 | None | gnomAD-3.1.2 | 6.57E-06 | |
19874 | 85 | V/A | 177 | rs1339819720 | 0.1498 | None | gnomAD-4.0.0 | 2.02997E-06 | |
19874 | 85 | V/I | 177 | None | 0.1498 | None | gnomAD-4.0.0 | 1.59549E-06 |