TITINdb

Map SAVs to Structure

Position	Domain position	SAV	Structural Position	RS	Q(SASA)	Disease	Source	MAF
13876	1	L/M	3	None	0.2708	None	gnomAD-4.0.0	1.62411E-06
13877	2	V/A	4	rs199969810	0.5036	None	gnomAD-4.0.0	1.63166E-06
13877	2	V/G	4	rs199969810	0.5036	None	gnomAD-4.0.0	2.87175E-04
13877	2	V/M	4	rs1272825852	0.5036	None	gnomAD-2.1.1	4.36E-06
13877	2	V/M	4	rs1272825852	0.5036	None	gnomAD-3.1.2	6.58E-06
13877	2	V/M	4	rs1272825852	0.5036	None	gnomAD-4.0.0	3.90504E-06
13878	3	K/N	5	None	0.5911	None	gnomAD-4.0.0	6.89888E-07
13880	5	I/L	8	rs1228888611	0.2035	None	gnomAD-2.1.1	4.34E-06
13880	5	I/L	8	rs1228888611	0.2035	None	gnomAD-4.0.0	6.89641E-07
13880	5	I/M	8	None	0.2035	None	gnomAD-4.0.0	2.06898E-06
13880	5	I/T	8	None	0.2035	None	gnomAD-4.0.0	1.62095E-06
13880	5	I/V	8	None	0.2035	None	gnomAD-4.0.0	6.89641E-07
13881	6	R/G	9	rs747469275	0.8442	None	gnomAD-2.1.1	8.71E-06
13881	6	R/G	9	rs747469275	0.8442	None	gnomAD-3.1.2	2.63E-05
13881	6	R/G	9	rs747469275	0.8442	None	gnomAD-4.0.0	2.08244E-05
13881	6	R/L	9	None	0.8442	None	gnomAD-4.0.0	6.89825E-07
13881	6	R/Q	9	rs1268138413	0.8442	None	gnomAD-2.1.1	1.31E-05
13881	6	R/Q	9	rs1268138413	0.8442	None	gnomAD-3.1.2	6.58E-06
13881	6	R/Q	9	rs1268138413	0.8442	None	gnomAD-4.0.0	6.24394E-06
13883	8	Q/K	13	None	0.1661	None	gnomAD-4.0.0	1.62151E-06
13884	9	H/Q	14	rs1361052408	0.7617	None	gnomAD-2.1.1	3.19E-05
13884	9	H/Q	14	rs1361052408	0.7617	None	gnomAD-3.1.2	6.58E-06
13884	9	H/Q	14	rs1361052408	0.7617	None	gnomAD-4.0.0	2.49721E-06
13884	9	H/R	14	rs1432673437	0.7617	None	gnomAD-2.1.1	4.34E-06
13884	9	H/R	14	rs1432673437	0.7617	None	gnomAD-4.0.0	6.89733E-06
13884	9	H/Y	14	None	0.7617	None	gnomAD-4.0.0	1.62177E-06
13886	11	K/T	18	None	0.9556	None	gnomAD-4.0.0	6.89835E-07
13887	12	P/R	23	rs1388854623	0.7263	None	gnomAD-2.1.1	8.73E-06
13887	12	P/R	23	rs1388854623	0.7263	None	gnomAD-4.0.0	4.83038E-06
13887	12	P/S	23	None	0.7263	None	gnomAD-4.0.0	1.62346E-06
13888	13	K/N	24	rs1459382951	0.6856	None	gnomAD-2.1.1	4.38E-06
13888	13	K/N	24	rs1459382951	0.6856	None	gnomAD-4.0.0	1.13721E-05
13888	13	K/R	24	rs1324858653	0.6856	None	gnomAD-4.0.0	1.62396E-06
13889	14	G/A	25	rs1029116705	0.2340	None	gnomAD-4.0.0	3.45193E-06
13889	14	G/E	25	rs1029116705	0.2340	None	gnomAD-2.1.1	4.39E-06
13889	14	G/E	25	rs1029116705	0.2340	None	gnomAD-4.0.0	6.90386E-07
13890	15	T/I	26	rs780566983	0.4242	None	gnomAD-2.1.1	4.41E-06
13890	15	T/I	26	rs780566983	0.4242	None	gnomAD-4.0.0	2.07224E-06
13890	15	T/R	26	rs780566983	0.4242	None	gnomAD-4.0.0	1.38149E-06
13892	17	I/M	29	None	0.4104	None	gnomAD-4.0.0	1.20032E-06
13894	19	A/V	31	rs1409834949	0.3439	None	gnomAD-2.1.1	4.46E-06
13894	19	A/V	31	rs1409834949	0.3439	None	gnomAD-4.0.0	1.63189E-06
13896	21	D/N	34	rs371312327	0.3578	None	gnomAD-2.1.1	4.49E-06
13896	21	D/V	34	None	0.3578	None	gnomAD-4.0.0	1.63394E-06
13897	22	I/T	35	rs1288360484	0.1461	None	gnomAD-3.1.2	6.58E-06
13897	22	I/T	35	rs1288360484	0.1461	None	gnomAD-4.0.0	3.75826E-06
13898	23	A/G	38	None	0.6002	None	gnomAD-4.0.0	1.6384E-06
13900	25	D/H	42	rs1188616797	0.6805	None	gnomAD-2.1.1	9.13E-06
13900	25	D/H	42	rs1188616797	0.6805	None	gnomAD-4.0.0	3.28008E-06
13901	26	T/P	43	None	0.1945	None	gnomAD-4.0.0	4.80129E-06
13901	26	T/S	43	None	0.1945	None	gnomAD-4.0.0	1.64096E-06
13902	27	P/T	44	rs865776326	0.6060	None	gnomAD-4.0.0	1.64128E-06
13906	31	W/R	48	None	0.1389	None	gnomAD-4.0.0	1.64324E-06
13907	32	F/L	49	rs1192032110	0.1142	None	gnomAD-4.0.0	2.08134E-06
13908	33	K/R	50	None	0.2382	None	gnomAD-4.0.0	1.20032E-06
13909	34	G/V	51	None	0.2715	None	gnomAD-4.0.0	6.93745E-07
13910	35	Y/C	52	rs1469876306	1.0665	None	gnomAD-4.0.0	1.64326E-06
13911	36	D/N	55	rs1209898521	0.7141	None	gnomAD-4.0.0	6.93692E-07
13911	36	D/Y	55	rs1209898521	0.7141	None	gnomAD-3.1.2	6.58E-06
13911	36	D/Y	55	rs1209898521	0.7141	None	gnomAD-4.0.0	6.57774E-06
13912	37	E/D	56	rs779199526	0.3433	None	gnomAD-2.1.1	4.59E-06
13913	38	I/V	58	None	0.1584	None	gnomAD-4.0.0	1.20032E-06
13914	39	P/S	59	rs755785975	0.5844	None	gnomAD-2.1.1	1.2E-05
13914	39	P/S	59	rs755785975	0.5844	None	gnomAD-3.1.2	6.58E-06
13914	39	P/S	59	rs755785975	0.5844	None	gnomAD-4.0.0	1.25469E-06
13915	40	A/V	70	rs371426048	0.6235	None	gnomAD-2.1.1	6.9E-05
13915	40	A/V	70	rs371426048	0.6235	None	gnomAD-3.1.2	3.29E-05
13915	40	A/V	70	rs371426048	0.6235	None	gnomAD-4.0.0	3.76528E-05
13916	41	E/D	71	None	0.9064	None	gnomAD-4.0.0	1.64186E-06
13916	41	E/K	71	None	0.9064	None	gnomAD-4.0.0	6.93514E-07
13917	42	P/A	72	rs2060335468	0.5931	None	gnomAD-3.1.2	6.59E-06
13917	42	P/A	72	rs2060335468	0.5931	None	gnomAD-4.0.0	6.58709E-06
13917	42	P/R	72	rs754567722	0.5931	None	gnomAD-2.1.1	2.31E-05
13917	42	P/R	72	rs754567722	0.5931	None	gnomAD-3.1.2	1.32E-05
13917	42	P/R	72	rs754567722	0.5931	None	gnomAD-4.0.0	1.00418E-05
13917	42	P/S	72	None	0.5931	None	gnomAD-4.0.0	6.93544E-07
13918	43	N/D	73	rs2060334868	0.3365	None	gnomAD-4.0.0	3.46618E-06
13918	43	N/K	73	rs1396769268	0.3365	None	gnomAD-2.1.1	3.19E-05
13918	43	N/K	73	rs1396769268	0.3365	None	gnomAD-3.1.2	1.32E-05
13918	43	N/K	73	rs1396769268	0.3365	None	gnomAD-4.0.0	1.3152E-05
13919	44	D/G	111	rs2060334191	1.0744	None	gnomAD-4.0.0	6.56463E-06
13920	45	K/Q	115	None	0.2371	None	gnomAD-4.0.0	6.93226E-07
13920	45	K/R	115	rs751156425	0.2371	None	gnomAD-2.1.1	9.15E-06
13920	45	K/R	115	rs751156425	0.2371	None	gnomAD-4.0.0	3.281E-06
13921	46	T/A	121	None	0.2329	None	gnomAD-4.0.0	1.20032E-06
13921	46	T/I	121	None	0.2329	None	gnomAD-4.0.0	6.93129E-07
13925	50	R/G	127	None	0.4190	None	gnomAD-4.0.0	1.20032E-06
13925	50	R/T	127	None	0.4190	None	gnomAD-4.0.0	6.92981E-07
13926	51	D/G	130	None	0.7576	None	gnomAD-4.0.0	1.20032E-06
13926	51	D/N	130	rs2060332594	0.7576	None	gnomAD-4.0.0	2.56338E-05
13927	52	G/R	131	rs758326922	0.3900	None	gnomAD-2.1.1	9.07E-06
13927	52	G/R	131	rs758326922	0.3900	None	gnomAD-3.1.2	1.32E-05
13927	52	G/R	131	rs758326922	0.3900	None	gnomAD-4.0.0	1.37868E-05
13927	52	G/V	131	None	0.3900	None	gnomAD-4.0.0	1.63738E-06
13929	54	H/Q	135	None	0.5324	None	gnomAD-4.0.0	1.63521E-06
13931	56	Y/C	137	None	0.3892	None	gnomAD-4.0.0	1.38395E-06
13931	56	Y/H	137	rs1162801145	0.3892	None	gnomAD-2.1.1	3.19E-05
13931	56	Y/H	137	rs1162801145	0.3892	None	gnomAD-3.1.2	6.57E-06
13931	56	Y/H	137	rs1162801145	0.3892	None	gnomAD-4.0.0	6.57488E-06
13936	61	N/H	143	None	0.4886	None	gnomAD-4.0.0	2.07122E-06
13937	62	A/D	144	None	0.1318	None	gnomAD-4.0.0	6.90088E-07
13937	62	A/V	144	rs545806408	0.1318	None	gnomAD-2.1.1	4.2682E-04
13937	62	A/V	144	rs545806408	0.1318	None	gnomAD-3.1.2	1.31581E-04
13937	62	A/V	144	rs545806408	0.1318	None	1000 genomes	1.39776E-03
13937	62	A/V	144	rs545806408	0.1318	None	gnomAD-4.0.0	1.69248E-04
13938	63	M/V	145	rs201725483	0.2863	None	gnomAD-2.1.1	3.86E-05
13938	63	M/V	145	rs201725483	0.2863	None	gnomAD-3.1.2	4.6E-05
13938	63	M/V	145	rs201725483	0.2863	None	gnomAD-4.0.0	1.13639E-04
13939	64	P/S	146	None	0.6482	None	gnomAD-4.0.0	1.6204E-06
13940	65	E/D	148	None	0.7837	None	gnomAD-4.0.0	3.23387E-06
13940	65	E/Q	148	rs1172846357	0.7837	None	gnomAD-2.1.1	3.19E-05
13940	65	E/Q	148	rs1172846357	0.7837	None	gnomAD-3.1.2	1.31E-05
13940	65	E/Q	148	rs1172846357	0.7837	None	gnomAD-4.0.0	5.61401E-06
13942	67	I/V	151	rs902514647	0.5211	None	gnomAD-2.1.1	3.19E-05
13944	69	E/V	153	None	0.4099	None	gnomAD-4.0.0	1.61311E-06
13946	71	A/T	155	None	0.0963	None	gnomAD-4.0.0	6.88053E-07
13949	74	I/V	158	None	0.1661	None	gnomAD-4.0.0	6.87561E-07
13953	78	R/I	163	rs1268324463	0.2394	None	gnomAD-2.1.1	4.21E-06
13953	78	R/I	163	rs1268324463	0.2394	None	gnomAD-4.0.0	3.21587E-06
13954	79	Y/C	164	None	0.2155	None	gnomAD-4.0.0	3.21484E-06
13954	79	Y/H	164	None	0.2155	None	gnomAD-4.0.0	2.74832E-06
13955	80	P/H	165	rs776863726	0.5011	None	gnomAD-3.1.2	6.58E-06
13955	80	P/H	165	rs776863726	0.5011	None	gnomAD-4.0.0	2.0531E-05
13955	80	P/L	165	rs776863726	0.5011	None	gnomAD-3.1.2	6.58E-06
13955	80	P/L	165	rs776863726	0.5011	None	gnomAD-4.0.0	1.86646E-06
13956	81	A/T	166	rs1176642239	0.0902	None	gnomAD-2.1.1	4.2E-06
13956	81	A/T	166	rs1176642239	0.0902	None	gnomAD-4.0.0	1.60727E-06
13956	81	A/V	166	rs2060324765	0.0902	None	gnomAD-3.1.2	6.58E-06
13957	82	K/N	168	None	0.5136	None	gnomAD-4.0.0	6.87104E-07
13958	83	L/V	178	None	0.1261	None	gnomAD-4.0.0	6.87166E-07

Position	Domain position	SAV	RS	Q(SASA)	Source	Structural Position	Disease	AlphaMissense (IC)	AlphaMissense (N2AB)	CADD	Condel	DUET	FATHMM	M-CAP	mCSM	MetaLR	MetaSVM	MPC	MutationAssessor	MutationTaster	MutPred	MVP	PolyPhen-2	PrimateAI	PROVEAN	REVEL	Rhapsody	SIFT	Zygosity	Comments	MAF	AFR	AMR	AMS	ASJ	EAS	EUR	FIN	MDE	NFE	SAS	OTH	Site Annotation	Predicted PPI	mCSM-PPI
13876	1	L/M	None	0.2708	gnomAD-4.0.0	3	None	0.3784	0.4334	27.1	N	None	0.89	0.021167	-0.863	0.2099	-0.6934	0.382631066902	2.85	0.988165	0.42	0.422524665647	0.997	0.51558983326	-1.44	0.144	0.697	0.022	None	None	1.62411E-06	0	0	0	0	None	0	0	1.62411E-06	2.9098E-06	0	0	None	N	None
13877	2	V/A	rs199969810	0.5036	gnomAD-4.0.0	4	None	0.4064	0.5735	24.4	D	None	0.89	0.017965	-0.344	0.1482	-0.8989	0.105975850844	2.505	0.997628	0.332	0.354183961838	0.132	0.269591480494	-2.8	0.185	0.252	0.039	None	None	1.63166E-06	0	2.40408E-05	0	0	None	0	0	1.63166E-06	0	0	0	None	N	None
13877	2	V/G	rs199969810	0.5036	gnomAD-4.0.0	4	None	0.4413	0.6312	None	D	-1.56	None	None	-0.45	None	None	None	None	None	None	None	0.919	None	None	0.27	0.556	None	None	None	2.87175E-04	1.15141E-04	2.40419E-05	0	1.1318E-04	None	2.9905E-03	0	2.87175E-04	2.62548E-05	0	2.15637E-04	None	N	None
13877	2	V/M	rs1272825852	0.5036	gnomAD-2.1.1	4	None	0.2934	0.3909	23.9	D	-0.329	0.85	0.022722	-0.368	0.3155	-0.4617	0.405371340211	2.965	0.999593	0.334	0.410603549233	0.996	0.27107578516	-1.99	0.289	0.523	0.011	None	None	4.36E-06	0	0	0	0	None	3.58E-05	None	4.36E-06	0	0	0	None	N	None
13877	2	V/M	rs1272825852	0.5036	gnomAD-3.1.2	4	None	0.2934	0.3909	23.9	D	-0.329	0.85	0.022722	-0.368	0.3155	-0.4617	0.405371340211	2.965	0.999593	0.334	0.410603549233	0.996	0.27107578516	-1.99	0.289	0.523	0.011	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	0	2.079E-04	0	None	N	None
13877	2	V/M	rs1272825852	0.5036	gnomAD-4.0.0	4	None	0.2934	0.3909	23.9	D	-0.329	0.85	0.022722	-0.368	0.3155	-0.4617	0.405371340211	2.965	0.999593	0.334	0.410603549233	0.996	0.27107578516	-1.99	0.289	0.523	0.011	None	None	3.90504E-06	0	0	0	2.45483E-05	None	0	0	3.90504E-06	0	2.76068E-05	0	None	N	None
13878	3	K/N	None	0.5911	gnomAD-4.0.0	5	None	0.8079	0.9021	24.5	D	None	0.9	0.029531	0.137	0.2406	-0.5963	0.402795335792	3.405	0.999428	0.461	0.17258766438	0.999	0.617805719376	-3.81	0.232	0.66	0.021	None	None	6.89888E-07	0	0	0	0	None	0	0	6.89888E-07	9.04254E-07	0	0	None	N	None
13880	5	I/L	rs1228888611	0.2035	gnomAD-2.1.1	8	None	0.1201	0.1276	22.1	N	-0.766	1.22	0.008625	-0.859	0.0513	-1.0494	0.0830569285264	-0.69	0.699324	0.33	0.187945064343	None	0.404009431601	-0.86	0.075	0.158	1.0	None	None	4.34E-06	0	3.07E-05	0	0	None	0	None	4.34E-06	0	0	0	None	N	None
13880	5	I/L	rs1228888611	0.2035	gnomAD-4.0.0	8	None	0.1201	0.1276	22.1	N	-0.766	1.22	0.008625	-0.859	0.0513	-1.0494	0.0830569285264	-0.69	0.699324	0.33	0.187945064343	None	0.404009431601	-0.86	0.075	0.158	1.0	None	None	6.89641E-07	0	2.31278E-05	0	0	None	0	0	6.89641E-07	0	0	0	None	N	None
13880	5	I/M	None	0.2035	gnomAD-4.0.0	8	None	0.3142	0.3166	18.63	N	None	0.95	0.045096	-0.635	0.1177	-0.5349	0.150935704758	1.685	0.999941	0.285	0.0611884634855	0.664	0.37596154213	-1.63	0.23	0.69	0.103	None	None	2.06898E-06	0	0	0	0	None	0	0	2.06898E-06	2.71247E-06	0	0	None	N	None
13880	5	I/T	None	0.2035	gnomAD-4.0.0	8	None	0.9523	0.9534	24.4	N	None	0.97	0.028223	-2.171	0.1394	-0.8802	0.149780803388	2.725	0.988779	0.479	0.468586609112	0.361	0.514066457748	-3.37	0.269	0.654	0.023	None	None	1.62095E-06	0	0	0	0	None	0	0	1.62095E-06	2.90612E-06	0	0	None	N	None
13880	5	I/V	None	0.2035	gnomAD-4.0.0	8	None	0.1716	0.1643	21.6	N	None	0.99	0.011265	-1.312	0.1296	-0.922	0.0773000946142	2.375	0.842537	0.254	0.286081765059	0.048	0.338814258575	-0.69	0.077	0.414	0.112	None	None	6.89641E-07	0	0	0	0	None	0	0	6.89641E-07	9.0412E-07	0	0	None	N	None
13881	6	R/G	rs747469275	0.8442	gnomAD-2.1.1	9	None	0.6974	0.8146	24.6	N	-0.979	0.97	0.017758	-0.095	0.1854	-0.6805	0.233132654031	3.105	0.98195	0.454	0.363158594168	0.983	0.601845562458	-5.06	0.226	0.636	0.003	None	None	8.71E-06	0	0	0	0	None	0	None	8.71E-06	0	1.95E-05	0	None	N	None
13881	6	R/G	rs747469275	0.8442	gnomAD-3.1.2	9	None	0.6974	0.8146	24.6	N	-0.979	0.97	0.017758	-0.095	0.1854	-0.6805	0.233132654031	3.105	0.98195	0.454	0.363158594168	0.983	0.601845562458	-5.06	0.226	0.636	0.003	None	None	2.63E-05	0	0	0	0	None	0	0	2.63E-05	5.88E-05	0	0	None	N	None
13881	6	R/G	rs747469275	0.8442	gnomAD-4.0.0	9	None	0.6974	0.8146	24.6	N	-0.979	0.97	0.017758	-0.095	0.1854	-0.6805	0.233132654031	3.105	0.98195	0.454	0.363158594168	0.983	0.601845562458	-5.06	0.226	0.636	0.003	None	None	2.08244E-05	0	0	0	0	None	0	0	2.08244E-05	3.64217E-05	0	2.87969E-05	None	N	None
13881	6	R/L	None	0.8442	gnomAD-4.0.0	9	None	0.6549	0.7757	25.7	N	None	0.92	0.028875	0.616	0.2375	-0.6592	0.325812919438	3.105	0.998425	0.418	0.379881503574	0.992	0.62793636322	-5.06	0.299	0.685	0.004	None	None	6.89825E-07	0	0	0	0	None	0	0	6.89825E-07	9.04295E-07	0	0	None	N	None
13881	6	R/Q	rs1268138413	0.8442	gnomAD-2.1.1	9	None	0.2411	0.3422	25.8	N	0.041	1.02	0.021468	0.151	0.2124	-0.7334	0.275733615944	2.13	0.988742	0.385	0.211220785272	0.998	0.555250048637	-2.89	0.254	0.613	0.115	None	None	1.31E-05	0	0	1.04406E-04	0	None	7.1E-05	None	1.31E-05	0	0	0	None	N	None
13881	6	R/Q	rs1268138413	0.8442	gnomAD-3.1.2	9	None	0.2411	0.3422	25.8	N	0.041	1.02	0.021468	0.151	0.2124	-0.7334	0.275733615944	2.13	0.988742	0.385	0.211220785272	0.998	0.555250048637	-2.89	0.254	0.613	0.115	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
13881	6	R/Q	rs1268138413	0.8442	gnomAD-4.0.0	9	None	0.2411	0.3422	25.8	N	0.041	1.02	0.021468	0.151	0.2124	-0.7334	0.275733615944	2.13	0.988742	0.385	0.211220785272	0.998	0.555250048637	-2.89	0.254	0.613	0.115	None	None	6.24394E-06	2.67867E-05	0	3.41553E-05	0	None	0	0	6.24394E-06	3.40765E-06	3.3692E-05	0	None	N	None
13883	8	Q/K	None	0.1661	gnomAD-4.0.0	13	None	0.6022	0.595	27.1	N	None	0.95	0.027949	-0.345	0.2593	-0.6634	0.493546718291	2.12	1.0	0.419	0.202086224978	0.993	0.573831319809	-3.02	0.344	0.314	0.467	None	None	1.62151E-06	0	0	0	0	None	0	0	1.62151E-06	0	0	3.05979E-05	None	N	None
13884	9	H/Q	rs1361052408	0.7617	gnomAD-2.1.1	14	None	0.8367	0.8378	23.4	N	0.195	1.02	0.018885	0.114	0.1777	-0.6972	0.269621044273	2.245	0.995944	0.247	0.177238962908	0.988	0.757804334164	-5.94	0.204	0.517	0.083	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	N	None
13884	9	H/Q	rs1361052408	0.7617	gnomAD-3.1.2	14	None	0.8367	0.8378	23.4	N	0.195	1.02	0.018885	0.114	0.1777	-0.6972	0.269621044273	2.245	0.995944	0.247	0.177238962908	0.988	0.757804334164	-5.94	0.204	0.517	0.083	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
13884	9	H/Q	rs1361052408	0.7617	gnomAD-4.0.0	14	None	0.8367	0.8378	23.4	N	0.195	1.02	0.018885	0.114	0.1777	-0.6972	0.269621044273	2.245	0.995944	0.247	0.177238962908	0.988	0.757804334164	-5.94	0.204	0.517	0.083	None	None	2.49721E-06	0	0	0	0	None	0	0	2.49721E-06	3.40783E-06	0	0	None	N	None
13884	9	H/R	rs1432673437	0.7617	gnomAD-2.1.1	14	None	0.7552	0.7541	27.5	N	-0.02	1.02	0.023872	-0.312	0.1772	-0.738	0.218789069538	2.39	0.999989	0.294	0.17948927462	0.92	0.77425467968	-5.98	0.268	0.509	0.097	None	None	4.34E-06	0	0	0	0	None	3.54E-05	None	4.34E-06	0	0	0	None	N	None
13884	9	H/R	rs1432673437	0.7617	gnomAD-4.0.0	14	None	0.7552	0.7541	27.5	N	-0.02	1.02	0.023872	-0.312	0.1772	-0.738	0.218789069538	2.39	0.999989	0.294	0.17948927462	0.92	0.77425467968	-5.98	0.268	0.509	0.097	None	None	6.89733E-06	0	0	0	0	None	0	0	6.89733E-06	7.23444E-06	1.18649E-05	1.66722E-05	None	N	None
13884	9	H/Y	None	0.7617	gnomAD-4.0.0	14	None	0.4676	0.4414	29.0	N	None	1.02	0.019044	0.989	0.2493	-0.6384	0.343973430666	2.59	0.999961	0.358	0.198526703765	0.993	0.773188948631	-4.03	0.416	0.515	0.046	None	None	1.62177E-06	0	0	0	0	None	1.91476E-05	0	1.62177E-06	0	0	0	None	N	None
13886	11	K/T	None	0.9556	gnomAD-4.0.0	18	None	0.6971	0.6448	25.9	N	None	0.99	0.030771	-0.162	0.2344	-0.6668	0.502031715641	1.875	0.999988	0.405	0.252162846088	0.999	0.690900921822	-4.2	0.341	0.793	0.058	None	None	6.89835E-07	0	0	0	0	None	0	0	6.89835E-07	9.04439E-07	0	0	None	N	None
13887	12	P/R	rs1388854623	0.7263	gnomAD-2.1.1	23	None	0.902	0.771	33.0	N	0.072	0.98	0.021825	0.093	0.2965	-0.5416	0.476242369952	2.565	1.0	0.389	0.36076525451	1.0	0.651039361954	-6.77	0.411	0.752	0.011	None	None	8.73E-06	0	0	0	0	None	0	None	8.73E-06	0	1.96E-05	0	None	I	None
13887	12	P/R	rs1388854623	0.7263	gnomAD-4.0.0	23	None	0.902	0.771	33.0	N	0.072	0.98	0.021825	0.093	0.2965	-0.5416	0.476242369952	2.565	1.0	0.389	0.36076525451	1.0	0.651039361954	-6.77	0.411	0.752	0.011	None	None	4.83038E-06	0	0	0	0	None	0	0	4.83038E-06	6.33231E-06	0	0	None	I	None
13887	12	P/S	None	0.7263	gnomAD-4.0.0	23	None	0.7808	0.6258	27.0	N	None	0.98	0.015991	-0.356	0.2708	-0.6345	0.464868906428	2.22	1.0	0.368	0.269558022972	1.0	0.593443453312	-6.01	0.32	0.795	0.023	None	None	1.62346E-06	0	0	0	0	None	0	0	1.62346E-06	2.91102E-06	0	0	None	I	None
13888	13	K/N	rs1459382951	0.6856	gnomAD-2.1.1	24	None	0.7839	0.8087	22.3	N	0.298	1.02	0.019749	0.37	0.1284	-0.9231	0.2404587666	2.11	0.965558	0.541	0.139678290688	0.883	0.587005019188	-3.61	0.126	0.556	0.027	None	None	4.38E-06	0	3.1E-05	0	0	None	0	None	4.38E-06	0	0	0	None	N	None
13888	13	K/N	rs1459382951	0.6856	gnomAD-4.0.0	24	None	0.7839	0.8087	22.3	N	0.298	1.02	0.019749	0.37	0.1284	-0.9231	0.2404587666	2.11	0.965558	0.541	0.139678290688	0.883	0.587005019188	-3.61	0.126	0.556	0.027	None	None	1.13721E-05	0	1.66786E-04	0	0	None	0	0	1.13721E-05	0	0	0	None	N	None
13888	13	K/R	rs1324858653	0.6856	gnomAD-4.0.0	24	None	0.1323	0.1216	23.1	D	0.099	0.97	0.023411	0.025	0.1431	-0.8963	0.0711494798745	1.855	0.982993	0.503	0.194818534648	0.015	0.48707473278	-2.17	0.165	0.399	0.275	None	None	1.62396E-06	0	0	0	0	None	0	0	1.62396E-06	2.91279E-06	0	0	None	N	None
13889	14	G/A	rs1029116705	0.2340	gnomAD-4.0.0	25	None	0.3486	0.3875	23.2	N	None	0.94	0.013505	-0.543	0.0746	-0.9873	0.0902298067989	-0.42	0.566396	0.267	0.0846915920261	None	0.495266139507	-2.81	0.106	0.15	0.633	None	None	3.45193E-06	0	0	0	0	None	0	1.73913E-04	3.45193E-06	1.80995E-06	1.18881E-05	1.66856E-05	None	N	None
13889	14	G/E	rs1029116705	0.2340	gnomAD-2.1.1	25	None	0.7209	0.7822	23.5	N	-1.447	1.14	0.010822	-1.128	0.0693	-0.9952	0.109721643832	0.42	0.664785	0.422	0.187945064343	0.001	0.574315905571	-4.66	0.1	0.364	0.452	None	None	4.39E-06	0	0	0	0	None	0	None	4.39E-06	0	9.83E-06	0	None	N	None
13889	14	G/E	rs1029116705	0.2340	gnomAD-4.0.0	25	None	0.7209	0.7822	23.5	N	-1.447	1.14	0.010822	-1.128	0.0693	-0.9952	0.109721643832	0.42	0.664785	0.422	0.187945064343	0.001	0.574315905571	-4.66	0.1	0.364	0.452	None	None	6.90386E-07	0	0	0	0	None	0	0	6.90386E-07	9.04976E-07	0	0	None	N	None
13890	15	T/I	rs780566983	0.4242	gnomAD-2.1.1	26	None	0.4811	0.4147	26.4	N	-0.135	0.83	0.056816	-0.103	0.2278	-0.6287	0.216670914144	2.72	0.995298	0.366	0.331365685468	0.987	0.44776776433	-4.03	0.263	0.382	0.012	None	None	4.41E-06	0	0	0	0	None	3.59E-05	None	4.41E-06	0	0	0	None	N	None
13890	15	T/I	rs780566983	0.4242	gnomAD-4.0.0	26	None	0.4811	0.4147	26.4	N	-0.135	0.83	0.056816	-0.103	0.2278	-0.6287	0.216670914144	2.72	0.995298	0.366	0.331365685468	0.987	0.44776776433	-4.03	0.263	0.382	0.012	None	None	2.07224E-06	0	0	0	0	None	0	3.47705E-04	2.07224E-06	0	1.19022E-05	0	None	N	None
13890	15	T/R	rs780566983	0.4242	gnomAD-4.0.0	26	None	0.6752	0.6411	26.1	N	-0.138	0.9	0.031952	-0.103	0.1249	-0.9302	0.145418511741	1.44	0.998327	0.406	0.443999229985	0.844	0.409002751112	-3.87	0.226	0.372	0.028	None	None	1.38149E-06	0	0	0	0	None	0	0	1.38149E-06	9.05315E-07	0	1.6695E-05	None	N	None
13892	17	I/M	None	0.4104	gnomAD-4.0.0	29	None	0.1743	0.2085	22.2	N	None	0.94	0.011766	-0.541	0.0796	-0.9906	0.09024269904	0.86	0.995751	0.301	0.350088858571	0.087	0.284423410892	-1.37	0.012	0.373	0.091	None	None	1.20032E-06	6.33473E-05	0	0	0	None	0	0	1.20032E-06	0	0	0	None	N	None
13894	19	A/V	rs1409834949	0.3439	gnomAD-2.1.1	31	None	0.1326	0.1415	22.5	N	-0.225	1.03	0.009706	-0.089	0.0719	-0.9834	0.0840471645538	0.895	0.998931	0.47	0.333651784274	0.006	0.255430996418	-1.16	0.056	0.362	0.153	None	None	4.46E-06	0	0	0	0	None	0	None	4.46E-06	0	1E-05	0	None	N	None
13894	19	A/V	rs1409834949	0.3439	gnomAD-4.0.0	31	None	0.1326	0.1415	22.5	N	-0.225	1.03	0.009706	-0.089	0.0719	-0.9834	0.0840471645538	0.895	0.998931	0.47	0.333651784274	0.006	0.255430996418	-1.16	0.056	0.362	0.153	None	None	1.63189E-06	0	0	0	0	None	0	0	1.63189E-06	2.92665E-06	0	0	None	N	None
13896	21	D/N	rs371312327	0.3578	gnomAD-2.1.1	34	None	0.0934	0.1215	None	N	-1.438	None	None	-1.241	None	None	None	None	None	None	None	0.013	None	None	0.084	0.527	None	None	None	4.49E-06	0	0	0	0	None	0	None	4.49E-06	0	1.01E-05	0	None	N	None
13896	21	D/V	None	0.3578	gnomAD-4.0.0	34	None	0.131	0.153	21.7	N	None	1.05	0.009652	0.167	0.0815	-1.0652	0.121073805104	1.175	0.999761	0.578	0.207176502487	None	0.273614346981	-4.74	0.104	0.454	0.103	None	None	1.63394E-06	0	0	0	0	None	0	0	1.63394E-06	2.93112E-06	0	0	None	N	None
13897	22	I/T	rs1288360484	0.1461	gnomAD-3.1.2	35	None	0.5418	0.6432	23.1	N	None	0.93	0.013619	-2.095	0.1317	-0.9486	0.114773647323	2.29	0.998616	0.562	0.537125817887	0.058	0.533942997456	-3.27	0.24	0.611	0.014	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
13897	22	I/T	rs1288360484	0.1461	gnomAD-4.0.0	35	None	0.5418	0.6432	23.1	N	None	0.93	0.013619	-2.095	0.1317	-0.9486	0.114773647323	2.29	0.998616	0.562	0.537125817887	0.058	0.533942997456	-3.27	0.24	0.611	0.014	None	None	3.75826E-06	1.33837E-05	0	0	0	None	0	0	3.75826E-06	4.27117E-06	0	0	None	N	None
13898	23	A/G	None	0.6002	gnomAD-4.0.0	38	None	0.2796	0.3582	24.0	N	None	0.95	0.004991	-0.294	0.0903	-1.0018	0.088512119463	1.735	0.928035	0.379	0.326074293725	0.181	0.414889127016	-2.46	0.09	0.264	0.347	None	None	1.6384E-06	0	0	0	2.82056E-05	None	0	0	1.6384E-06	0	0	0	None	N	None
13900	25	D/H	rs1188616797	0.6805	gnomAD-2.1.1	42	None	0.8379	0.7767	25.4	N	-0.277	0.96	0.148989	0.066	0.1754	-0.75	0.242879665762	3.015	0.999998	0.542	0.260249123532	0.862	0.537763476372	-4.62	0.403	0.367	0.01	None	None	9.13E-06	7.44E-05	0	0	0	None	3.66E-05	None	9.13E-06	0	0	0	None	N	None
13900	25	D/H	rs1188616797	0.6805	gnomAD-4.0.0	42	None	0.8379	0.7767	25.4	N	-0.277	0.96	0.148989	0.066	0.1754	-0.75	0.242879665762	3.015	0.999998	0.542	0.260249123532	0.862	0.537763476372	-4.62	0.403	0.367	0.01	None	None	3.28008E-06	5.72541E-05	0	0	0	None	0	0	3.28008E-06	0	1.49107E-05	0	None	N	None
13901	26	T/P	None	0.1945	gnomAD-4.0.0	43	None	0.7918	0.7035	24.9	N	None	1.02	0.017924	-0.162	0.2642	-0.5404	0.471595129817	1.87	0.999996	0.489	0.322510055762	1.0	0.512981653214	-4.23	0.43	0.683	0.037	None	None	4.80129E-06	0	0	0	0	None	0	0	4.80129E-06	5.25001E-06	0	0	None	N	None
13901	26	T/S	None	0.1945	gnomAD-4.0.0	43	None	0.478	0.4717	22.8	N	None	0.99	0.013714	-0.765	0.135	-0.8196	0.107167239837	1.76	0.999936	0.341	0.203808441222	0.816	0.521469831467	-2.99	0.195	0.349	0.272	None	None	1.64096E-06	0	0	0	0	None	0	0	1.64096E-06	2.94488E-06	0	0	None	N	None
13902	27	P/T	rs865776326	0.6060	gnomAD-4.0.0	44	None	0.574	0.5305	24.5	N	None	0.68	0.014284	-0.392	0.3278	-0.4705	0.487905608832	2.595	1.0	0.559	0.400899426204	1.0	0.643236041069	-5.91	0.432	0.796	0.019	None	None	1.64128E-06	0	0	0	0	None	0	0	1.64128E-06	0	1.49102E-05	0	None	N	None
13906	31	W/R	None	0.1389	gnomAD-4.0.0	48	None	0.9998	0.9997	29.2	D	None	-2.2	0.080814	-2.497	0.8126	0.7986	0.614382434124	3.845	1.0	0.708	0.907460717844	0.999	0.796887934208	-10.58	0.776	0.811	0.005	None	None	1.64324E-06	0	0	0	0	None	0	0	1.64324E-06	2.9494E-06	0	0	None	N	None
13907	32	F/L	rs1192032110	0.1142	gnomAD-4.0.0	49	None	0.9825	0.9714	24.4	N	None	1.02	0.021458	-2.145	0.0946	-1.0635	0.0975493673825	0.35	0.9987	0.31	0.292787519742	None	0.522561311722	-3.76	0.116	0.227	0.48	None	None	2.08134E-06	0	2.40941E-05	0	0	None	0	0	2.08134E-06	9.08447E-07	0	1.67577E-05	None	N	None
13908	33	K/R	None	0.2382	gnomAD-4.0.0	50	None	0.0791	0.0778	22.7	N	None	0.76	0.036794	-0.612	0.1361	-0.8919	0.0697083379935	1.69	0.977185	0.449	0.173771789658	0.007	0.437667101622	-2.2	0.112	0.286	0.074	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
13909	34	G/V	None	0.2715	gnomAD-4.0.0	51	None	0.8008	0.6995	25.6	D	None	0.84	0.02903	0.229	0.2722	-0.4171	0.38769052009	3.465	1.0	0.412	0.499535901811	0.981	0.609839677811	-6.53	0.304	0.837	0.008	None	None	6.93745E-07	0	0	0	0	None	0	0	6.93745E-07	9.08473E-07	0	0	None	N	None
13910	35	Y/C	rs1469876306	1.0665	gnomAD-4.0.0	52	None	0.3279	0.2642	31.0	N	None	0.99	0.013986	-0.008	0.1314	-0.9251	0.284678371979	1.5	0.999195	0.426	0.394079506076	0.985	0.550333976746	-4.97	0.23	0.345	0.179	None	None	1.64326E-06	0	0	0	0	None	0	0	1.64326E-06	2.94994E-06	0	0	None	N	None
13911	36	D/N	rs1209898521	0.7141	gnomAD-4.0.0	55	None	0.2169	0.2174	23.2	N	None	1.01	0.011213	-0.309	0.0886	-1.0101	0.0817148320359	0.11	0.890301	0.304	0.12205267543	0.003	0.354964256287	-2.88	0.086	0.123	0.14	None	None	6.93692E-07	0	0	0	0	None	0	0	6.93692E-07	0	1.19523E-05	0	None	N	None
13911	36	D/Y	rs1209898521	0.7141	gnomAD-3.1.2	55	None	0.5287	0.5573	23.3	N	None	1.0	0.0111	0.308	0.1199	-0.9438	0.126715881735	2.16	0.988042	0.409	0.362361684037	0.306	0.368254482746	-5.76	0.174	0.531	0.005	None	None	6.58E-06	0	0	0	1.94024E-04	None	0	0	6.58E-06	0	0	0	None	N	None
13911	36	D/Y	rs1209898521	0.7141	gnomAD-4.0.0	55	None	0.5287	0.5573	23.3	N	None	1.0	0.0111	0.308	0.1199	-0.9438	0.126715881735	2.16	0.988042	0.409	0.362361684037	0.306	0.368254482746	-5.76	0.174	0.531	0.005	None	None	6.57774E-06	0	0	0	1.94024E-04	None	0	0	6.57774E-06	0	0	0	None	N	None
13912	37	E/D	rs779199526	0.3433	gnomAD-2.1.1	56	None	0.5049	0.5535	23.3	D	-0.78	0.87	0.032321	-0.854	0.1165	-0.8452	0.155788624017	3.215	0.588701	0.248	0.219573609325	0.709	0.529732167721	-2.37	0.124	0.473	0.189	None	None	4.59E-06	0	3.25E-05	0	0	None	0	None	4.59E-06	0	0	0	None	N	None
13913	38	I/V	None	0.1584	gnomAD-4.0.0	58	None	0.4525	0.5174	22.3	N	None	0.9	0.011753	-1.205	0.1293	-0.9508	0.07750036299	1.275	0.988814	0.312	0.377451072189	0.041	0.517010390759	-0.76	0.09	0.507	0.261	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	0	3.66327E-05	None	N	None
13914	39	P/S	rs755785975	0.5844	gnomAD-2.1.1	59	None	0.2331	0.2171	23.5	N	-0.184	0.99	0.081176	-0.616	0.1397	-0.8323	0.131119992834	1.59	0.999692	0.234	0.167679373172	0.92	0.452038258314	-5.34	0.218	0.371	0.021	None	None	1.2E-05	0	0	0	5.79E-05	None	0	None	1.2E-05	0	1.8E-05	0	None	N	None
13914	39	P/S	rs755785975	0.5844	gnomAD-3.1.2	59	None	0.2331	0.2171	23.5	N	-0.184	0.99	0.081176	-0.616	0.1397	-0.8323	0.131119992834	1.59	0.999692	0.234	0.167679373172	0.92	0.452038258314	-5.34	0.218	0.371	0.021	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
13914	39	P/S	rs755785975	0.5844	gnomAD-4.0.0	59	None	0.2331	0.2171	23.5	N	-0.184	0.99	0.081176	-0.616	0.1397	-0.8323	0.131119992834	1.59	0.999692	0.234	0.167679373172	0.92	0.452038258314	-5.34	0.218	0.371	0.021	None	None	1.25469E-06	0	0	0	0	None	0	0	1.25469E-06	1.71072E-06	0	0	None	N	None
13915	40	A/V	rs371426048	0.6235	gnomAD-2.1.1	70	None	0.0786	0.0879	None	N	-0.024	None	None	-0.346	None	None	None	None	None	None	None	0.014	None	None	0.017	0.164	None	None	None	6.9E-05	0	1.95185E-04	0	6.36E-05	None	1.09186E-04	None	6.9E-05	0	5.25E-05	0	None	I	None
13915	40	A/V	rs371426048	0.6235	gnomAD-3.1.2	70	None	0.0786	0.0879	None	N	-0.024	None	None	-0.346	None	None	None	None	None	None	None	0.014	None	None	0.017	0.164	None	None	None	3.29E-05	2.42E-05	6.57E-05	0	0	None	0	0	3.29E-05	2.94E-05	0	4.79846E-04	None	I	None
13915	40	A/V	rs371426048	0.6235	gnomAD-4.0.0	70	None	0.0786	0.0879	None	N	-0.024	None	None	-0.346	None	None	None	None	None	None	None	0.014	None	None	0.017	0.164	None	None	None	3.76528E-05	4.01725E-05	1.58467E-04	0	2.26224E-05	None	0	0	3.76528E-05	2.65232E-05	1.46846E-04	4.85893E-05	None	I	None
13916	41	E/D	None	0.9064	gnomAD-4.0.0	71	None	0.1802	0.2062	22.3	N	None	1.07	0.019501	-0.225	0.0728	-1.065	0.0777069865228	1.445	0.98922	0.25	0.0806252709748	0.034	0.439620614052	-1.54	0.021	0.312	0.187	None	None	1.64186E-06	0	0	0	0	None	1.92589E-05	0	1.64186E-06	0	0	0	None	I	None
13916	41	E/K	None	0.9064	gnomAD-4.0.0	71	None	0.2894	0.2454	22.4	N	None	0.98	0.072941	0.318	0.1239	-0.9975	0.0980938221825	1.96	0.999837	0.455	0.173771789658	0.132	0.507102847099	-2.57	0.229	0.334	0.352	None	None	6.93514E-07	0	0	0	0	None	0	0	6.93514E-07	9.0831E-07	0	0	None	I	None
13917	42	P/A	rs2060335468	0.5931	gnomAD-3.1.2	72	None	0.1528	0.1235	25.9	D	None	1.0	0.011507	-0.527	0.3116	-0.4746	0.455590952444	2.265	1.0	0.226	0.252681307341	0.999	0.493796527386	-5.84	0.361	0.731	0.136	None	None	6.59E-06	2.42E-05	0	0	0	None	0	0	6.59E-06	0	0	0	None	N	None
13917	42	P/A	rs2060335468	0.5931	gnomAD-4.0.0	72	None	0.1528	0.1235	25.9	D	None	1.0	0.011507	-0.527	0.3116	-0.4746	0.455590952444	2.265	1.0	0.226	0.252681307341	0.999	0.493796527386	-5.84	0.361	0.731	0.136	None	None	6.58709E-06	2.41885E-05	0	0	0	None	0	0	6.58709E-06	0	0	0	None	N	None
13917	42	P/R	rs754567722	0.5931	gnomAD-2.1.1	72	None	0.4876	0.3489	26.7	D	0.318	0.99	0.019031	0.151	0.3143	-0.469	0.476242369952	2.77	1.0	0.263	0.417081434665	1.0	0.543857693672	-6.6	0.358	0.769	0.002	None	None	2.31E-05	0	0	0	0	None	1.82123E-04	None	2.31E-05	0	0	0	None	N	None
13917	42	P/R	rs754567722	0.5931	gnomAD-3.1.2	72	None	0.4876	0.3489	26.7	D	0.318	0.99	0.019031	0.151	0.3143	-0.469	0.476242369952	2.77	1.0	0.263	0.417081434665	1.0	0.543857693672	-6.6	0.358	0.769	0.002	None	None	1.32E-05	0	0	0	0	None	0	0	1.32E-05	0	4.158E-04	0	None	N	None
13917	42	P/R	rs754567722	0.5931	gnomAD-4.0.0	72	None	0.4876	0.3489	26.7	D	0.318	0.99	0.019031	0.151	0.3143	-0.469	0.476242369952	2.77	1.0	0.263	0.417081434665	1.0	0.543857693672	-6.6	0.358	0.769	0.002	None	None	1.00418E-05	0	0	0	0	None	0	0	1.00418E-05	0	1.80766E-04	0	None	N	None
13917	42	P/S	None	0.5931	gnomAD-4.0.0	72	None	0.386	0.2937	26.8	N	None	1.04	0.011195	-0.402	0.2544	-0.6848	0.464868906428	2.145	1.0	0.221	0.21737058555	1.0	0.5015001297	-5.91	0.321	0.762	0.109	None	None	6.93544E-07	0	0	0	0	None	0	0	6.93544E-07	9.08328E-07	0	0	None	N	None
13918	43	N/D	rs2060334868	0.3365	gnomAD-4.0.0	73	None	0.1396	0.1391	22.3	N	None	1.04	0.014721	0.095	0.0964	-0.9802	0.0997905954404	0.43	0.946816	0.258	0.130388298395	0.011	0.299381226301	-2.26	0.126	0.409	0.098	None	None	3.46618E-06	9.00793E-05	0	0	0	None	0	0	3.46618E-06	9.0812E-07	0	1.67482E-05	None	N	None
13918	43	N/K	rs1396769268	0.3365	gnomAD-2.1.1	73	None	0.6558	0.6916	20.9	N	-0.127	1.0	0.009045	0.041	0.066	-1.0251	0.0996061284925	1.1	0.704821	0.366	0.0611884634855	0.011	0.303495943546	-2.45	0.021	0.336	0.043	None	None	3.19E-05	1.14784E-04	0	0	0	None	0	None	3.19E-05	0	0	0	None	N	None
13918	43	N/K	rs1396769268	0.3365	gnomAD-3.1.2	73	None	0.6558	0.6916	20.9	N	-0.127	1.0	0.009045	0.041	0.066	-1.0251	0.0996061284925	1.1	0.704821	0.366	0.0611884634855	0.011	0.303495943546	-2.45	0.021	0.336	0.043	None	None	1.32E-05	4.83E-05	0	0	0	None	0	0	1.32E-05	0	0	0	None	N	None
13918	43	N/K	rs1396769268	0.3365	gnomAD-4.0.0	73	None	0.6558	0.6916	20.9	N	-0.127	1.0	0.009045	0.041	0.066	-1.0251	0.0996061284925	1.1	0.704821	0.366	0.0611884634855	0.011	0.303495943546	-2.45	0.021	0.336	0.043	None	None	1.3152E-05	4.82532E-05	0	0	0	None	0	0	1.3152E-05	0	0	0	None	N	None
13919	44	D/G	rs2060334191	1.0744	gnomAD-4.0.0	111	None	0.314	0.32	24.4	N	None	1.04	0.020808	-0.073	0.1317	-0.9145	0.122578150867	2.715	0.999998	0.319	0.185906805712	0.457	0.461621046066	-4.35	0.195	0.539	0.034	None	None	6.56463E-06	0	0	0	1.12816E-04	None	0	0	6.56463E-06	0	0	0	None	I	None
13920	45	K/Q	None	0.2371	gnomAD-4.0.0	115	None	0.5278	0.522	24.8	D	None	0.88	0.018861	-0.164	0.3001	-0.4038	0.476305088485	3.245	0.999985	0.444	0.215109475489	0.999	0.530425965786	-3.16	0.355	0.724	0.136	None	None	6.93226E-07	0	0	0	0	None	0	0	6.93226E-07	9.08102E-07	0	0	None	N	None
13920	45	K/R	rs751156425	0.2371	gnomAD-2.1.1	115	None	0.1391	0.1502	31.0	N	0.016	1.25	0.011563	-0.319	0.1936	-0.7891	0.417361578228	1.775	0.999978	0.385	0.219573609325	0.997	0.503570377827	-2.37	0.194	0.637	0.323	None	None	9.15E-06	0	0	0	0	None	7.25E-05	None	9.15E-06	0	0	0	None	N	None
13920	45	K/R	rs751156425	0.2371	gnomAD-4.0.0	115	None	0.1391	0.1502	31.0	N	0.016	1.25	0.011563	-0.319	0.1936	-0.7891	0.417361578228	1.775	0.999978	0.385	0.219573609325	0.997	0.503570377827	-2.37	0.194	0.637	0.323	None	None	3.281E-06	0	0	0	0	None	0	0	3.281E-06	0	2.96824E-05	0	None	N	None
13921	46	T/A	None	0.2329	gnomAD-4.0.0	121	None	0.2779	0.3176	24.4	N	None	1.0	0.026434	-0.877	0.116	-0.868	0.103935340526	2.35	0.985292	0.3	0.101711395817	0.817	0.415608614683	-3.28	0.152	0.474	0.256	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
13921	46	T/I	None	0.2329	gnomAD-4.0.0	121	None	0.3099	0.3873	24.1	N	None	1.09	0.026195	0.172	0.1189	-1.0089	0.0916761220119	0.255	0.991694	0.351	0.186928172975	0.126	0.501357078552	-3.9	0.189	0.398	0.253	None	None	6.93129E-07	0	0	0	0	None	0	0	6.93129E-07	9.08001E-07	0	0	None	N	None
13925	50	R/G	None	0.4190	gnomAD-4.0.0	127	None	0.5238	0.5691	23.0	N	None	1.02	0.036926	-0.498	0.0869	-0.9426	0.110058870898	1.59	0.581466	0.488	0.335414705075	0.058	0.291425377131	-3.79	0.186	0.451	0.052	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
13925	50	R/T	None	0.4190	gnomAD-4.0.0	127	None	0.4225	0.4186	21.5	N	None	1.03	0.008859	-0.24	0.0697	-1.0004	0.128035948112	1.245	0.940856	0.447	0.229264304666	0.058	0.309224903584	-3.03	0.065	0.447	0.083	None	None	6.92981E-07	0	0	0	0	None	0	0	6.92981E-07	0	0	1.67493E-05	None	N	None
13926	51	D/G	None	0.7576	gnomAD-4.0.0	130	None	0.3454	0.3553	24.3	N	None	0.86	0.025445	-0.445	0.1865	-0.7877	0.127319244009	3.355	0.999936	0.381	0.188950314367	0.189	0.326373815536	-4.17	0.27	0.51	0.043	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	0	3.66327E-05	None	N	None
13926	51	D/N	rs2060332594	0.7576	gnomAD-4.0.0	130	None	0.1606	0.1581	23.5	N	None	0.91	0.023821	-0.043	0.1588	-0.8372	0.0948372849257	3.01	0.99996	0.358	0.195762928549	0.449	0.340436577797	-2.62	0.247	0.558	0.05	None	None	2.56338E-05	0	0	0	0	None	0	0	2.56338E-05	3.35837E-05	0	0	None	N	None
13927	52	G/R	rs758326922	0.3900	gnomAD-2.1.1	131	None	0.504	0.4539	24.7	D	-0.987	0.61	0.018121	-0.537	0.3738	-0.2727	0.505774648429	3.27	1.0	0.512	0.704213449561	1.0	0.533376693726	-6.08	0.443	0.849	0.002	None	None	9.07E-06	0	0	0	0	None	7.17E-05	None	9.07E-06	0	0	0	None	N	None
13927	52	G/R	rs758326922	0.3900	gnomAD-3.1.2	131	None	0.504	0.4539	24.7	D	-0.987	0.61	0.018121	-0.537	0.3738	-0.2727	0.505774648429	3.27	1.0	0.512	0.704213449561	1.0	0.533376693726	-6.08	0.443	0.849	0.002	None	None	1.32E-05	0	0	0	0	None	0	0	1.32E-05	0	4.14594E-04	0	None	N	None
13927	52	G/R	rs758326922	0.3900	gnomAD-4.0.0	131	None	0.504	0.4539	24.7	D	-0.987	0.61	0.018121	-0.537	0.3738	-0.2727	0.505774648429	3.27	1.0	0.512	0.704213449561	1.0	0.533376693726	-6.08	0.443	0.849	0.002	None	None	1.37868E-05	0	0	0	0	None	0	0	1.37868E-05	0	2.47497E-04	0	None	N	None
13927	52	G/V	None	0.3900	gnomAD-4.0.0	131	None	0.6878	0.7641	None	D	None	None	None	-0.331	None	None	None	None	None	None	None	1.0	None	None	0.474	0.815	None	None	None	1.63738E-06	0	0	0	0	None	0	0	1.63738E-06	2.94095E-06	0	0	None	N	None
13929	54	H/Q	None	0.5324	gnomAD-4.0.0	135	None	0.2107	0.2921	17.15	N	None	1.02	0.004271	-0.215	0.0763	-0.9688	0.0849059257558	1.87	0.941783	0.315	0.0551355673512	0.007	0.268686085939	-3.65	0.043	0.243	0.327	None	None	1.63521E-06	0	0	0	0	None	0	0	1.63521E-06	2.93708E-06	0	0	None	N	None
13931	56	Y/C	None	0.3892	gnomAD-4.0.0	137	None	0.18	0.236	12.85	N	None	0.96	0.009379	-1.299	0.0621	-0.9003	0.126919247447	1.04	1.0	0.388	0.0482279557977	0.257	0.309347093105	-3.07	0.085	0.487	0.175	None	None	1.38395E-06	3.0021E-05	0	0	0	None	0	0	1.38395E-06	9.06918E-07	0	0	None	N	None
13931	56	Y/H	rs1162801145	0.3892	gnomAD-2.1.1	137	None	0.1274	0.1677	17.22	N	-1.606	0.98	0.003852	-1.678	0.0501	-1.0308	0.108866262484	0.835	1.0	0.378	0.0762999501168	None	0.315457046032	-2.13	0.057	0.171	0.537	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	N	None
13931	56	Y/H	rs1162801145	0.3892	gnomAD-3.1.2	137	None	0.1274	0.1677	17.22	N	-1.606	0.98	0.003852	-1.678	0.0501	-1.0308	0.108866262484	0.835	1.0	0.378	0.0762999501168	None	0.315457046032	-2.13	0.057	0.171	0.537	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
13931	56	Y/H	rs1162801145	0.3892	gnomAD-4.0.0	137	None	0.1274	0.1677	17.22	N	-1.606	0.98	0.003852	-1.678	0.0501	-1.0308	0.108866262484	0.835	1.0	0.378	0.0762999501168	None	0.315457046032	-2.13	0.057	0.171	0.537	None	None	6.57488E-06	0	0	0	0	None	0	0	6.57488E-06	1.47111E-05	0	0	None	N	None
13936	61	N/H	None	0.4886	gnomAD-4.0.0	143	None	0.336	0.373	28.8	D	None	0.78	0.016075	-0.743	0.3215	-0.3525	0.429551444564	2.915	0.999994	0.312	0.223847106136	1.0	0.544878661633	-3.68	0.346	0.567	0.017	None	None	2.07122E-06	0	0	0	0	None	0	0	2.07122E-06	2.71602E-06	0	0	None	N	None
13937	62	A/D	None	0.1318	gnomAD-4.0.0	144	None	0.9927	0.9936	26.4	N	None	0.81	0.029128	-2.253	0.2275	-0.5586	0.369608477173	3.02	0.99847	0.49	0.566919426312	0.963	0.504269063473	-4.33	0.256	0.771	0.017	None	None	6.90088E-07	0	2.33242E-05	0	0	None	0	0	6.90088E-07	0	0	0	None	N	None
13937	62	A/V	rs545806408	0.1318	gnomAD-2.1.1	144	None	0.2796	0.2039	23.7	N	-0.426	1.15	0.013031	-0.602	0.096	-1.0371	0.0843713859066	1.185	0.994112	0.287	0.327686398923	0.016	0.443854391575	-2.56	0.072	0.418	0.079	None	None	4.2682E-04	0	0	0	0	None	3.32773E-03	None	4.2682E-04	0	1.99E-05	0	None	N	None
13937	62	A/V	rs545806408	0.1318	gnomAD-3.1.2	144	None	0.2796	0.2039	23.7	N	-0.426	1.15	0.013031	-0.602	0.096	-1.0371	0.0843713859066	1.185	0.994112	0.287	0.327686398923	0.016	0.443854391575	-2.56	0.072	0.418	0.079	None	None	1.31581E-04	2.41E-05	0	0	0	None	0	0	1.31581E-04	0	3.94518E-03	0	None	N	None
13937	62	A/V	rs545806408	0.1318	1000 genomes	144	None	0.2796	0.2039	23.7	N	-0.426	1.15	0.013031	-0.602	0.096	-1.0371	0.0843713859066	1.185	0.994112	0.287	0.327686398923	0.016	0.443854391575	-2.56	0.072	0.418	0.079	None	None	1.39776E-03	0	0	None	0	0	None	None	1.39776E-03	None	7.2E-03	None	None	N	None
13937	62	A/V	rs545806408	0.1318	gnomAD-4.0.0	144	None	0.2796	0.2039	23.7	N	-0.426	1.15	0.013031	-0.602	0.096	-1.0371	0.0843713859066	1.185	0.994112	0.287	0.327686398923	0.016	0.443854391575	-2.56	0.072	0.418	0.079	None	None	1.69248E-04	1.33504E-05	0	0	0	None	0	0	1.69248E-04	5.11537E-06	2.77175E-03	2.58006E-04	None	N	None
13938	63	M/V	rs201725483	0.2863	gnomAD-2.1.1	145	None	0.1049	0.0938	None	N	-0.408	None	None	-1.109	None	None	None	None	None	None	None	None	None	None	0.072	0.087	None	None	None	3.86E-05	0	0	0	0	None	0	None	3.86E-05	0	8.58E-05	0	None	N	None
13938	63	M/V	rs201725483	0.2863	gnomAD-3.1.2	145	None	0.1049	0.0938	None	N	-0.408	None	None	-1.109	None	None	None	None	None	None	None	None	None	None	0.072	0.087	None	None	None	4.6E-05	0	0	0	0	None	0	0	4.6E-05	1.02959E-04	0	0	None	N	None
13938	63	M/V	rs201725483	0.2863	gnomAD-4.0.0	145	None	0.1049	0.0938	None	N	-0.408	None	None	-1.109	None	None	None	None	None	None	None	None	None	None	0.072	0.087	None	None	None	1.13639E-04	1.33636E-05	0	0	0	None	0	0	1.13639E-04	1.48321E-04	0	1.12896E-04	None	N	None
13939	64	P/S	None	0.6482	gnomAD-4.0.0	146	None	0.4562	0.4349	26.1	N	None	0.95	0.011735	-0.242	0.3125	-0.458	0.464868906428	2.85	1.0	0.296	0.209622950755	1.0	0.520751237869	-5.58	0.343	0.819	0.088	None	None	1.6204E-06	0	0	0	0	None	0	0	1.6204E-06	0	1.46297E-05	0	None	N	None
13940	65	E/D	None	0.7837	gnomAD-4.0.0	148	None	0.1169	0.1484	22.2	N	None	0.86	0.007736	-0.21	0.0677	-1.019	0.076612375576	0.23	0.862573	0.243	0.119812018005	0.002	0.365331709385	-1.01	0.058	0.18	0.485	None	None	3.23387E-06	0	0	0	0	None	0	0	3.23387E-06	5.80713E-06	0	0	None	N	None
13940	65	E/Q	rs1172846357	0.7837	gnomAD-2.1.1	148	None	0.293	0.3111	23.1	N	0.129	0.79	0.040256	0.182	0.1747	-0.7804	0.156111087451	2.22	0.998772	0.319	0.183819452728	0.791	0.354868859053	-1.91	0.169	0.44	0.106	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	N	None
13940	65	E/Q	rs1172846357	0.7837	gnomAD-3.1.2	148	None	0.293	0.3111	23.1	N	0.129	0.79	0.040256	0.182	0.1747	-0.7804	0.156111087451	2.22	0.998772	0.319	0.183819452728	0.791	0.354868859053	-1.91	0.169	0.44	0.106	None	None	1.31E-05	0	0	0	0	None	0	0	1.31E-05	2.94E-05	0	0	None	N	None
13940	65	E/Q	rs1172846357	0.7837	gnomAD-4.0.0	148	None	0.293	0.3111	23.1	N	0.129	0.79	0.040256	0.182	0.1747	-0.7804	0.156111087451	2.22	0.998772	0.319	0.183819452728	0.791	0.354868859053	-1.91	0.169	0.44	0.106	None	None	5.61401E-06	0	0	0	0	None	0	0	5.61401E-06	7.66605E-06	0	0	None	N	None
13942	67	I/V	rs902514647	0.5211	gnomAD-2.1.1	151	None	0.0836	0.0765	18.73	N	-0.902	1.02	0.02545	-0.568	0.0652	-1.0293	0.0703051542146	-0.33	0.8817	0.313	0.232513804876	None	0.265307754278	-0.39	0.038	0.146	0.523	None	None	3.19E-05	1.14732E-04	0	0	0	None	0	None	3.19E-05	0	0	0	None	N	None
13944	69	E/V	None	0.4099	gnomAD-4.0.0	153	None	0.7063	0.5903	25.9	N	None	1.02	0.053236	-0.234	0.2924	-0.4345	0.498535268662	2.43	0.999999	0.495	0.423836183345	0.999	0.493054986	-4.99	0.521	0.778	0.014	None	None	1.61311E-06	0	2.34973E-05	0	0	None	0	0	1.61311E-06	0	0	0	None	N	None
13946	71	A/T	None	0.0963	gnomAD-4.0.0	155	None	0.4645	0.2357	22.8	N	None	1.21	0.01268	-1.39	0.0792	-1.0713	0.0886726636444	-0.055	0.998417	0.285	0.0954503805726	0.028	0.462092101574	-2.16	0.085	0.37	0.436	None	None	6.88053E-07	0	0	0	0	None	0	0	6.88053E-07	0	0	1.6645E-05	None	N	None
13949	74	I/V	None	0.1661	gnomAD-4.0.0	158	None	0.1588	0.13	22.6	N	None	1.13	0.012172	-1.604	0.0374	-1.0785	0.0704899027279	-1.045	0.73813	0.346	0.12205267543	None	0.382392674685	-0.28	0.037	0.127	1.0	None	None	6.87561E-07	0	0	0	0	None	0	0	6.87561E-07	0	0	1.66317E-05	None	N	None
13953	78	R/I	rs1268324463	0.2394	gnomAD-2.1.1	163	None	0.7671	0.6061	23.5	N	0.573	0.09	0.036206	0.158	0.2257	-0.7745	0.154882509621	1.415	0.999996	0.456	0.353336612579	0.126	0.490856945515	-5.84	0.22	0.412	0.007	None	None	4.21E-06	0	0	0	0	None	3.39E-05	None	4.21E-06	0	0	0	None	N	None
13953	78	R/I	rs1268324463	0.2394	gnomAD-4.0.0	163	None	0.7671	0.6061	23.5	N	0.573	0.09	0.036206	0.158	0.2257	-0.7745	0.154882509621	1.415	0.999996	0.456	0.353336612579	0.126	0.490856945515	-5.84	0.22	0.412	0.007	None	None	3.21587E-06	0	0	0	2.80081E-05	None	0	0	3.21587E-06	0	1.45075E-05	0	None	N	None
13954	79	Y/C	None	0.2155	gnomAD-4.0.0	164	None	0.6539	0.5304	24.0	D	None	-0.14	0.031162	-1.426	0.2501	-0.6611	0.106651462539	1.905	0.966311	0.503	0.37568098594	0.004	0.566672801971	-6.47	0.311	0.409	0.043	None	None	3.21484E-06	0	0	0	0	None	0	0	3.21484E-06	5.76671E-06	0	0	None	N	None
13954	79	Y/H	None	0.2155	gnomAD-4.0.0	164	None	0.7216	0.58	27.4	D	None	-0.12	0.019672	-1.388	0.3315	-0.2721	0.305821779893	2.71	0.978077	0.387	0.39724302092	0.924	0.576956510544	-3.58	0.286	0.465	0.132	None	None	2.74832E-06	0	0	0	0	None	0	3.47464E-04	2.74832E-06	1.80369E-06	0	0	None	N	None
13955	80	P/H	rs776863726	0.5011	gnomAD-3.1.2	165	None	0.6438	0.416	23.5	N	-0.72	0.14	0.033015	-0.958	0.2142	-0.4586	0.158412767844	1.7	0.805066	0.333	0.443388199986	0.621	0.443545401096	-5.22	0.258	0.512	0.044	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
13955	80	P/H	rs776863726	0.5011	gnomAD-4.0.0	165	None	0.6438	0.416	23.5	N	-0.72	0.14	0.033015	-0.958	0.2142	-0.4586	0.158412767844	1.7	0.805066	0.333	0.443388199986	0.621	0.443545401096	-5.22	0.258	0.512	0.044	None	None	2.0531E-05	0	0	0	0	None	0	0	2.0531E-05	2.80424E-05	0	0	None	N	None
13955	80	P/L	rs776863726	0.5011	gnomAD-3.1.2	165	None	0.396	0.2205	23.4	N	None	0.18	0.036505	-0.573	0.2335	-0.7643	0.0901395718251	1.01	0.999634	0.376	0.37479162749	0.03	0.466300010681	-5.73	0.235	0.515	0.22	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
13955	80	P/L	rs776863726	0.5011	gnomAD-4.0.0	165	None	0.396	0.2205	23.4	N	None	0.18	0.036505	-0.573	0.2335	-0.7643	0.0901395718251	1.01	0.999634	0.376	0.37479162749	0.03	0.466300010681	-5.73	0.235	0.515	0.22	None	None	1.86646E-06	1.33743E-05	0	0	0	None	0	0	1.86646E-06	8.49771E-07	0	1.60689E-05	None	N	None
13956	81	A/T	rs1176642239	0.0902	gnomAD-2.1.1	166	None	0.7898	0.7815	24.8	D	-1.577	-0.38	0.040174	-1.488	0.58	0.21	0.386515749672	3.715	0.999999	0.352	0.589992848803	0.999	0.603915989399	-3.02	0.452	0.701	0.029	None	None	4.2E-06	0	0	0	0	None	0	None	4.2E-06	0	9.34E-06	0	None	N	None
13956	81	A/T	rs1176642239	0.0902	gnomAD-4.0.0	166	None	0.7898	0.7815	24.8	D	-1.577	-0.38	0.040174	-1.488	0.58	0.21	0.386515749672	3.715	0.999999	0.352	0.589992848803	0.999	0.603915989399	-3.02	0.452	0.701	0.029	None	None	1.60727E-06	0	0	0	0	None	0	0	1.60727E-06	2.88264E-06	0	0	None	N	None
13956	81	A/V	rs2060324765	0.0902	gnomAD-3.1.2	166	None	0.8653	0.855	33.0	D	None	-0.38	0.047725	-0.246	0.5769	0.2047	0.385573126211	3.715	0.999995	0.41	0.61427494375	0.999	0.623054206371	-3.02	0.47	0.663	0.185	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
13957	82	K/N	None	0.5136	gnomAD-4.0.0	168	None	0.5846	0.6104	23.5	D	None	-0.37	0.021696	-0.535	0.2894	-0.6357	0.0996588253401	2.84	0.996641	0.446	0.222439326576	0.007	0.681226611137	-3.58	0.202	0.247	0.01	None	None	6.87104E-07	0	0	0	0	None	0	0	6.87104E-07	9.01808E-07	0	0	None	N	None
13958	83	L/V	None	0.1261	gnomAD-4.0.0	178	None	0.5222	0.4647	27.9	D	None	-0.57	0.054731	-1.404	0.6119	0.37	0.461749125381	3.74	0.999958	0.328	0.690638299042	0.997	0.631266772747	-2.03	0.451	0.549	0.033	None	None	6.87166E-07	0	0	0	0	None	0	0	6.87166E-07	9.01837E-07	0	0	None	N	None

Whole Population MAF	African (AFR)	Latin American (AMR)
Amish (AMS)	Ashkenazi Jewish (ASJ)	East Asian (EAS)
European/1KGP (EUR)	Finnish (FIN)	Middle Eastern (MDE)
Non-Finnish European (NFE)	South Asian (SAS)	Other (OTH)

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